A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor

Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2001, Pages 917-922

  DeVita, R J ^a   Walsh, T F ^a   Young, J R ^a   Jiang, J ^a   Ujjainwalla, F ^a   Toupence, R B ^a   Parikh, M ^a   Huang, S X ^a   Fair, J A ^a   Goulet, M T ^a   Wyvratt, M J ^a   Lo, J L ^a   Ren, N ^a   Yudkovitz, J B ^a   Yang, Y T ^a   Cheng, K ^a   Cui, J ^a   Mount, G ^a   Rohrer, S P ^a   Schaeffer, J M ^a   Rhodes, L ^a,c   Drisko, J E ^a   McGowan, E ^a   MacIntyre, D E ^a   Vincent, S ^a   Carlin, J R ^a   Cameron, J ^b   Smith, R G ^a,d   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (AZETIDIN 2 YL)ETHOXY] 7 CHLORO 2 OXO 3 (3,4,5 TRIMETHYLPHENYL) 1,2 DIHYDROQUINOLINE 6 CARBOXYLIC ACID PYRIMIDIN 4 YLAMIDE; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; QUINOLONE DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MEMBRANE BINDING; NONHUMAN; PHARMACOPHORE; RAT; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZETIDINES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; HUMANS; MACACA MULATTA; PITUITARY GLAND; QUINOLONES; RADIOLIGAND ASSAY; RATS; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035866652     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000275p     Document Type: Article

References (13)

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