Multivalency in lectins - A crystallographic, modelling and light-scattering study involving peanut lectin and a bivalent ligand

Current Science

Volumn 90, Issue 9, 2006, Pages 1230-1237

  Natchiar, S Kundhavai ^a   Srinivas, O ^a   Mitra, Nivedita ^a   Dev, Sagarika ^a   Jayaraman, N ^a   Surolia, A ^a   Vijayan, M ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Crosslinking; Crystal structure prediction; Crystalline array; Lectin carbohydrate interactions; Ligand specificity

Indexed keywords

ARACHIS HYPOGAEA;

EID: 33744484324     PISSN: 00113891     EISSN: 00113891     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Lis, H. and Sharon, N., Lectins: carbohydrate-specific proteins that mediate cellular recognition. Chem. Rev., 1998, 98, 637-674.
2. Vijayan, M. and Chandra, N., Lectins. Curr. Opin. Struct. Biol., 1999, 9, 707-714.
3. Loris, R., Principles of structures of animal and plant lectins. Biochim. Biophys. Acta, 2002, 1572, 198-208.
4. Bettler, H. M., Loris, R. and Imberty, A., Lectin database available online at http://cermav.cnrs.fr/lectines.
5. Brewer, C. F., Binding and crosslinking properties of galectin. Biochim. Biophys. Acta, 2002, 1572, 255-262.
6. Drickamer, K.. Multiplicity of lectin carbohydrate interactions. Nature Struct. Biol., 1995, 2, 437-439.
7. Brewer, C. F., Multivalent lectin-carbohydrate crosslinking interactions. Chemtracts Biochem. Mol. Biol., 1996, 6, 165-179.
8. Brewer, C. F., Miceli, M. C. and Baum, L. G., Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions. Curr. Opin. Struct. Biol., 2002, 12, 616-623.
9. Weis, W. I., Drickamer, K. and Hendrickson, W. A., Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature, 1992, 360, 127-134.
10. Bourne, Y. et al., Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides. Nature Struct. Biol., 1994, 1, 863-870.
11. Olsen, L. R., Dessen, A., Gupta, D., Sabesan, S., Sacchettini, J. and Brewer, C. F., X-ray crystallographic studies of unique crosslinked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin. Biochemistry, 1997, 36, 15073-15080.
12. Sacchettini, J. C., Baum, L. G. and Brewer, C. F., Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction. Biochemistry, 2001, 40, 3009-3015.
13. Wright, C. S. and Hester, G., The 2.0 Å structure of a cross-linked complex between snowdrop lectin and a branched mannopentose: evidence for two unique binding modes. Structure, 1996, 4, 1339-1352.
14. Hamelryck, T. W., Moore, J. G., Chrispeels, M. J., Loris, R. and Wyns, L., The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: Crystal structure of cross-linked FRIL. J. Mol. Biol., 2000, 299, 875-883.
15. Ramachandraiah, G., Chandra, N. R., Surolia, A. and Vijayan, M., Computational analysis of multivalency in lectin structures of garlic lectin-oligosaccharide complexes and their aggregates. Glycobiology, 2003, 13, 765-775.
16. Banerjee, R., Das, K., Ravishankar, R., Suguna, K., Surolia, A. and Vijayan, M., Conformation of protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex. J. Mol. Biol., 1996, 256, 281-296.
17. Ravishankar, R., Ravindran, M., Suguna, K., Surolia, A. and Vijayan, M., Crystal structure of the peanut lectin-T-antigen complex. Carbohydrate specificity generated by water bridges. Curr. Sci., 1997, 72, 855-861.
18. Ravishankar, R., Suguna, K., Surolia, A. and Vijayan, M., Structure of the complexes of peanut lectin with methyl-β-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNac specific legume lectins. Acta Crystallogr. Sect. D, 1999, 55, 1375-1382.
19. Ravishankar, R., Thomas, C. J., Suguna, K., Surolia, A. and Vijayan, M., Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry and crystal packing directed by interactions at the combining site. Proteins, 2001, 43, 260-270.
20. Natchiar, S. K., Jeyaprakash, A. A., Ramya, T. N. C., Thomas, C. J., Suguna, K., Surolia, A. and Vijayan, M., Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure. Acta Crystallogr. Sect. D, 2004, 60, 211-219.
21. Srinivas, O., Mitra, N., Surolia, A. and Jayaraman, N., Photoswitchable multivalent sugar ligands: synthesis, isomerization, and lectin binding studies of azobenzene-glycopyranoside derivatives. J. Am. Chem. Soc., 2002, 124, 2124-2125.
22. Srinivas, O., Mitra, N., Surolia, A. and Jayaraman, N., Photoswitchable cluster glycosides as tools to probe carbohydrate-protein interactions: synthesis and lectin-binding studies of azobenzene containing multivalent sugar ligands. Glycobiology, 2005, 15, 861-873.
23. Otwinowski, Z., In Proceedings of the CCP4 Study Weekend. Data Collection and Processing (eds Sawyer, L. et al.), Daresbury Laboratory, Warringtom, 1993, pp. 56-62.
24. CCP4 (Collaborative Computational Project, No. 4). Acta Crystallogr. Sect. D, 1994, 50, 760-763.
25. Navaza, AMoRe: an automated package for molecular replacement. Acta Crystallogr. Sect. A, 1994, 50, 157-163.
26. Cohen, G. E., ALIGN: a program to superimpose protein coordinates, accounting for insertions and deletions. J. Appl. Crystallogr., 1997, 30, 1160-1161.
27. DeLano, L. W., The case for open-source software in drug discovery. Drug Discovery Today, 2005, 10, 213-217.
28. Kraulis, P. J., MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr., 1991, 24, 946-950.
29. Lee, K. K. and Johnson, J. E., Complementary approaches to structure determination of icosahedral viruses. Curr. Opin. Struct. Biol., 2003, 13, 558-569.
30. Orlova, E. V. and Saibil, H. R., Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Curr. Opin. Struct. Biol., 2004, 14, 584-590.
31. Berman, H. M. et al., The protein data bank. Nucleic Acids Res., 2000, 28, 235-242.