Synthesis of Hsp90 dimerization modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3529-3532

  Chiosis, Gabriela ^a   Aguirre, Julia ^a   Nicchitta, Christopher V ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chemical modulator of dimerization; Geldanamycin; Hsp90

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; BENZOQUINONE DERIVATIVE; MACROCYCLIC LACTAM; QUINONE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DIMERIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MICHAEL ADDITION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BENZOQUINONES; BINDING, COMPETITIVE; DIMERIZATION; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MOLECULAR STRUCTURE; QUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33744477399     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.092     Document Type: Article

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