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Volumn 50, Issue 2, 2006, Pages 281-290

Polycystic ovary syndrome, metabolic syndrome, cardiovascular risk and the role of insulin sensitizing agents;Síndrome dos ovários policísticos, síndrome metabólica, risco cardiovascular e o papel dos agentes sensibilizadores da insulina

Author keywords

Cardiovascular risk; Glitazones; Insulin resistance; Metabolic syndrome; Metformin; Polycystic ovary syndrome

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT;

EID: 33744469893     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302006000200014     Document Type: Review
Times cited : (16)

References (66)
  • 1
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005;352:1223-36.
    • (2005) N Engl J Med , vol.352 , pp. 1223-1236
    • Ehrmann, D.A.1
  • 2
    • 23844453653 scopus 로고    scopus 로고
    • Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span
    • Azziz R, Marin C, Hoq L, Badamgarav E, Song P. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab 2005;90:4650-8.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4650-4658
    • Azziz, R.1    Marin, C.2    Hoq, L.3    Badamgarav, E.4    Song, P.5
  • 3
    • 30344480230 scopus 로고    scopus 로고
    • Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism
    • Carmina E, Rosato F, Jannì A, Rizzo M, Longo RA. Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. J Clin Endocrinol Metab 2006;91:2-6.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2-6
    • Carmina, E.1    Rosato, F.2    Jannì, A.3    Rizzo, M.4    Longo, R.A.5
  • 5
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-7.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 6
    • 17044370727 scopus 로고    scopus 로고
    • The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    • Escobar-Morreale HF, Luque-Ramírez M, San Millán JL. The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocr Rev 2005;26:251-82.
    • (2005) Endocr Rev , vol.26 , pp. 251-282
    • Escobar-Morreale, H.F.1    Luque-Ramírez, M.2    San Millán, J.L.3
  • 7
    • 23844519581 scopus 로고    scopus 로고
    • Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome
    • Wickenheisser JK, Nelson-DeGrave VL, Hendricks KL, Legro RS, Strauss JF, McAllister M. Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4858-65.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4858-4865
    • Wickenheisser, J.K.1    Nelson-DeGrave, V.L.2    Hendricks, K.L.3    Legro, R.S.4    Strauss, J.F.5    McAllister, M.6
  • 8
    • 15944407338 scopus 로고    scopus 로고
    • Dysregulation of cytochrome P450 17a-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome
    • Wickenheisser JK, Nelson DeGrave VL, McAllister JM. Dysregulation of cytochrome P450 17a-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:1720-7.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1720-1727
    • Wickenheisser, J.K.1    Nelson DeGrave, V.L.2    McAllister, J.M.3
  • 9
    • 30344458775 scopus 로고    scopus 로고
    • Identification of a functional polymorphism of the human type 5 17β-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome
    • Qin K, Ehrmann DA, Cox N, Refetoff S, Rosenfield RL. Identification of a functional polymorphism of the human type 5 17β-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome. J Clin Endocrinol Metab 2006;91:270-6.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 270-276
    • Qin, K.1    Ehrmann, D.A.2    Cox, N.3    Refetoff, S.4    Rosenfield, R.L.5
  • 10
    • 23044516980 scopus 로고    scopus 로고
    • A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphism in the polycystic ovary syndrome
    • San Millán JL, Botella-Carretero JI, Álvarez-Blasco F, Luque-Ramírez M, Sancho J, Moghetti P, et al. A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphism in the polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4157-62.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4157-4162
    • San Millán, J.L.1    Botella-Carretero, J.I.2    Álvarez-Blasco, F.3    Luque-Ramírez, M.4    Sancho, J.5    Moghetti, P.6
  • 11
    • 4544323736 scopus 로고    scopus 로고
    • Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: Effects of prepubertal initiation and post pubertal discontinuation of metformin treatment
    • Ibánez L, Valls C, Marcos MV, Ong K, Dunger DB, de Zegher F. Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and post pubertal discontinuation of metformin treatment. J Clin Endocrinol Metab 2004;89:4331-7.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4331-4337
    • Ibánez, L.1    Valls, C.2    Marcos, M.V.3    Ong, K.4    Dunger, D.B.5    De Zegher, F.6
  • 12
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997;18:774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 13
    • 0347362865 scopus 로고    scopus 로고
    • Altered cortisol metabolism in polycystic ovary syndrome: Insulin enhances 5a-reduction but not the elevated adrenal steroid production rates
    • Tsilchorozidou T, Honou JW, Conway GS. Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5a-reduction but not the elevated adrenal steroid production rates. J Clin Endocrinol Metab 2003;88:5907-13.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5907-5913
    • Tsilchorozidou, T.1    Honou, J.W.2    Conway, G.S.3
  • 14
    • 30344438541 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: A syndrome of ovarian hypersensitivity of insulin?
    • Baillargeon JP, Nestler JE. Polycystic ovary syndrome: a syndrome of ovarian hypersensitivity of insulin? J Clin Endocrinol Metab 2006;91:22-4.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 22-24
    • Baillargeon, J.P.1    Nestler, J.E.2
  • 15
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
    • Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T. Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 1992;41:1257-66.
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Segal, K.R.2    Shelley, D.R.3    Green, G.4    Dobrjansky, A.5    Licholai, T.6
  • 16
    • 27744459241 scopus 로고    scopus 로고
    • Central fat excess in polycystic ovary syndrome: Relation to low-grade inflammation and insulin resistance
    • Puder JJ, Varga S, Kraenzlin M, de Geyter C, Keller U, Müller B. Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance. J Clin Endocrinol Metab 2005;90:6014-21.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6014-6021
    • Puder, J.J.1    Varga, S.2    Kraenzlin, M.3    De Geyter, C.4    Keller, U.5    Müller, B.6
  • 17
    • 0037631831 scopus 로고    scopus 로고
    • Insulin resistance and chronic cardiovascular inflammatory syndrome
    • Fernández-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003;24:278-301.
    • (2003) Endocr Rev , vol.24 , pp. 278-301
    • Fernández-Real, J.M.1    Ricart, W.2
  • 19
    • 24344501691 scopus 로고    scopus 로고
    • Hyperglycemia alters tumor necrosis factor-a release from mononuclear cells in women with polycystic ovary syndrome
    • González F, Minium J, Rote NS, Kirwan JP. Hyperglycemia alters tumor necrosis factor-a release from mononuclear cells in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:5336-42.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5336-5342
    • González, F.1    Minium, J.2    Rote, N.S.3    Kirwan, J.P.4
  • 20
    • 30344440819 scopus 로고    scopus 로고
    • Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome
    • González F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab 2006;91:336-40.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 336-340
    • González, F.1    Rote, N.S.2    Minium, J.3    Kirwan, J.P.4
  • 21
    • 0032948363 scopus 로고    scopus 로고
    • Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
    • Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 2005;84:165-9.
    • (2005) J Clin Endocrinol Metab , vol.84 , pp. 165-169
    • Legro, R.S.1    Kunselman, A.R.2    Dodson, W.C.3    Dunaif, A.4
  • 22
    • 12244279029 scopus 로고    scopus 로고
    • Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome
    • Ehrmann DA, Kasza K, Azziz R, Legro RS, Ghazzi MN; The PCOS/Troglitazone Study Group. Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:66-71.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 66-71
    • Ehrmann, D.A.1    Kasza, K.2    Azziz, R.3    Legro, R.S.4    Ghazzi, M.N.5
  • 23
    • 21244465167 scopus 로고    scopus 로고
    • Changes in glucose tolerance over time in women with polycystic ovary syndrome: A controlled study
    • Legro RS, Gnatuk CL, Kunselman AR, Dunaif A. Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study. J Clin Endocrinol Metab 2005;90:3236-42.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3236-3242
    • Legro, R.S.1    Gnatuk, C.L.2    Kunselman, A.R.3    Dunaif, A.4
  • 24
    • 0035702339 scopus 로고    scopus 로고
    • Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
    • Legro RS, Kunselman AR, Dunaif A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 2001;111:665-6.
    • (2001) Am J Med , vol.111 , pp. 665-666
    • Legro, R.S.1    Kunselman, A.R.2    Dunaif, A.3
  • 25
    • 0026689423 scopus 로고
    • Risk factors for coronary artery disease in lean and obese women with polycystic ovary syndrome
    • Conway GS, Agrawal R, Betteridge DJ, Jacobs HS. Risk factors for coronary artery disease in lean and obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 1992;37:119-25.
    • (1992) Clin Endocrinol (Oxf) , vol.37 , pp. 119-125
    • Conway, G.S.1    Agrawal, R.2    Betteridge, D.J.3    Jacobs, H.S.4
  • 27
    • 17844367331 scopus 로고    scopus 로고
    • Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome
    • Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:1929-35.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1929-1935
    • Apridonidze, T.1    Essah, P.A.2    Iuorno, M.J.3    Nestler, J.E.4
  • 28
    • 33645324218 scopus 로고    scopus 로고
    • Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance
    • Epub ahead of print
    • Coviello AD, Legro RS, Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab 2005;[Epub ahead of print]
    • (2005) J Clin Endocrinol Metab
    • Coviello, A.D.1    Legro, R.S.2    Dunaif, A.3
  • 29
    • 27744599917 scopus 로고    scopus 로고
    • Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: Results of a 6-month study
    • Orio Jr F, Palomba S, Cascella T, de Simone B, Manguso F, Savastano S, et al. Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab 2005;90:6072-6.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6072-6076
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3    De Simone, B.4    Manguso, F.5    Savastano, S.6
  • 30
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439-51.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 32
    • 26244450785 scopus 로고    scopus 로고
    • Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease
    • Meyer C, Mcgrath BP, Teede HJ. Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. J Clin Endocrinol Metab 2005;90:5711-6.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5711-5716
    • Meyer, C.1    Mcgrath, B.P.2    Teede, H.J.3
  • 35
    • 8744310157 scopus 로고    scopus 로고
    • Endothelial dysfunction in young women with polycystic ovary syndrome: Relationship with insulin resistance and low-grade chronic inflammation
    • Tarkun I, Arslan BÇ, Cantürk Z, Türemen E, Sahin T, Duman C. Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. J Clin Endocrinol Metab 2004;89:5592-6.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5592-5596
    • Tarkun, I.1    Arslan, B.Ç.2    Cantürk, Z.3    Türemen, E.4    Sahin, T.5    Duman, C.6
  • 36
    • 2442434415 scopus 로고    scopus 로고
    • Increased C-reactive protein levels in the polycystic ovary syndrome: A marker of cardiovascular disease
    • Boulman N, Levy Y, Leiba R, Shachar S, Linn R, Zinder O, et al. Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease. J Clin Endocrinol Metab 2004;89:2160-5.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2160-2165
    • Boulman, N.1    Levy, Y.2    Leiba, R.3    Shachar, S.4    Linn, R.5    Zinder, O.6
  • 37
    • 18844433823 scopus 로고    scopus 로고
    • Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters
    • Carmina E, Chu MC, Longo RA, Rini GB, Lobo RA. Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters. J Clin Endocrinol Metab 2005;90:2545-9.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2545-2549
    • Carmina, E.1    Chu, M.C.2    Longo, R.A.3    Rini, G.B.4    Lobo, R.A.5
  • 38
    • 0030855145 scopus 로고    scopus 로고
    • Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome
    • Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, et al. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:2108-16.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2108-2116
    • Ehrmann, D.A.1    Schneider, D.J.2    Sobel, B.E.3    Cavaghan, M.K.4    Imperial, J.5    Rosenfield, R.L.6
  • 40
    • 0038307320 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and cardiovascular disease: A premature association?
    • Legro RS. Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev 2003;24:302-12.
    • (2003) Endocr Rev , vol.24 , pp. 302-312
    • Legro, R.S.1
  • 42
    • 18844408055 scopus 로고    scopus 로고
    • Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome
    • Vryonidou A, Papatheodorou A, Tavridou A, Terzi T, Loi V, Vatalas IA, et al. Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:2740-6.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2740-2746
    • Vryonidou, A.1    Papatheodorou, A.2    Tavridou, A.3    Terzi, T.4    Loi, V.5    Vatalas, I.A.6
  • 44
    • 4544265733 scopus 로고    scopus 로고
    • Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome
    • Orio Jr F, Palomba S, Cascella T, de Simone B, di Biasi S, Russo T, et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:4588-93.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4588-4593
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3    De Simone, B.4    Di Biasi, S.5    Russo, T.6
  • 45
    • 4043104723 scopus 로고    scopus 로고
    • The cardiovascular risk of young women with polycystic ovary syndrome: An observational, analytical, prospective case-control study
    • Orio Jr F, Palomba S, Spinelli L, Cascella T, Tauchmanovà L, Zullo F, et al. The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study. J Clin Endocrinol Metab 2004;89:3696-701.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3696-3701
    • Orio Jr., F.1    Palomba, S.2    Spinelli, L.3    Cascella, T.4    Tauchmanovà, L.5    Zullo, F.6
  • 46
    • 4344639792 scopus 로고    scopus 로고
    • Editorial: Cardiovascular risk in PCOS
    • Guzick DS. Editorial: cardiovascular risk in PCOS. J Clin Endocrinol Metab 2004;89:3694-5.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3694-3695
    • Guzick, D.S.1
  • 47
    • 0027080247 scopus 로고
    • Polycystic ovary syndrome and risk factor model based on a prospective population study of women
    • Dahlgren E, Janson PO, Johansson S, Lapidus L, Oden A. Polycystic ovary syndrome and risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand 1992;71:599-604.
    • (1992) Acta Obstet Gynecol Scand , vol.71 , pp. 599-604
    • Dahlgren, E.1    Janson, P.O.2    Johansson, S.3    Lapidus, L.4    Oden, A.5
  • 48
    • 0031025124 scopus 로고    scopus 로고
    • Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization
    • Birdsall MA, Farquhar CM, White HD. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Ann Intern Med 1997;126:32-5.
    • (1997) Ann Intern Med , vol.126 , pp. 32-35
    • Birdsall, M.A.1    Farquhar, C.M.2    White, H.D.3
  • 51
    • 0034078044 scopus 로고    scopus 로고
    • Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: A retrospective cohort study
    • Wild S, Pierpoint T, McKeigue P, Jacobs H. Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study. Clin Endocrinol 2000;52:595-600.
    • (2000) Clin Endocrinol , vol.52 , pp. 595-600
    • Wild, S.1    Pierpoint, T.2    McKeigue, P.3    Jacobs, H.4
  • 52
    • 2442532679 scopus 로고    scopus 로고
    • Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study
    • Taponen S, Martikainen H, Järvelin MR, Sovio U, Laitinen J, Pouta A, et al. Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J Clin Endocrinol Metab 2004;89:2114-8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2114-2118
    • Taponen, S.1    Martikainen, H.2    Järvelin, M.R.3    Sovio, U.4    Laitinen, J.5    Pouta, A.6
  • 54
    • 0034892698 scopus 로고    scopus 로고
    • Metformin directly inhibits androgen production in human thecal cells
    • Attia GR, Rainey WE, Carr BR. Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 2001;76:517-24.
    • (2001) Fertil Steril , vol.76 , pp. 517-524
    • Attia, G.R.1    Rainey, W.E.2    Carr, B.R.3
  • 55
    • 11144354560 scopus 로고    scopus 로고
    • Ethinylestradiol-drospirenone, flutamide-metformin or both for adolescents and women with hyperinsulinemic hyperandrogenism: Opposite effects on adipocytokines and body adiposity
    • Ibánez L, Zegher F. Ethinylestradiol-drospirenone, flutamide-metformin or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. J Clin Endocrinol Metab 2004;89:1592-7.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1592-1597
    • Ibánez, L.1    Zegher, F.2
  • 56
    • 6344233338 scopus 로고    scopus 로고
    • Metformin - Comparison with other therapies in ovulation induction in polycystic ovary syndrome
    • Norman RJ. Metformin - comparison with other therapies in ovulation induction in polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:4797-800.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4797-4800
    • Norman, R.J.1
  • 57
    • 0035044332 scopus 로고    scopus 로고
    • Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome
    • Jakubowicz DJ, Seppälä M, Jacubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:1126-33.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1126-1133
    • Jakubowicz, D.J.1    Seppälä, M.2    Jacubowicz, S.3    Rodriguez-Armas, O.4    Rivas-Santiago, A.5    Koistinen, H.6
  • 58
    • 23844436916 scopus 로고    scopus 로고
    • Metformin and weight loss in obese women with polycystic ovary syndrome: Comparison of doses
    • Harborne LR, Sattar N, Norman JE, Fleming R. Metformin and weight loss in obese women with polycystic ovary syndrome: comparison of doses. J Clin Endocrinol Metab 2005;90:4593-8.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4593-4598
    • Harborne, L.R.1    Sattar, N.2    Norman, J.E.3    Fleming, R.4
  • 59
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Järvinen H. Thiazolidinediones. N Engl J Med 2004;351:1106-18.
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Järvinen, H.1
  • 60
    • 27744483698 scopus 로고    scopus 로고
    • Direct thiazolidinedione action in the human ovary: Insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production
    • Seto-Young D, Paliou M, Schlosser J, Avtanski D, Park A, Patel P, et al. Direct thiazolidinedione action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production. J Clin Endocrinol Metab 2005;90:6099-105.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6099-6105
    • Seto-Young, D.1    Paliou, M.2    Schlosser, J.3    Avtanski, D.4    Park, A.5    Patel, P.6
  • 61
    • 0035907330 scopus 로고    scopus 로고
    • Thiazolidinediones but not metfomin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase
    • Arlt W, Auchus J, Miller WL. Thiazolidinediones but not metfomin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase. J Biol Chemistry 2001;20:16767-71.
    • (2001) J Biol Chemistry , vol.20 , pp. 16767-16771
    • Arlt, W.1    Auchus, J.2    Miller, W.L.3
  • 62
    • 2342631940 scopus 로고    scopus 로고
    • Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3β-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARγ agonist activity
    • Arlt W, Neogi P, Gross C, Miller WL. Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3β-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARγ agonist activity. J Mol Endocrinol 2004;32:425-36.
    • (2004) J Mol Endocrinol , vol.32 , pp. 425-436
    • Arlt, W.1    Neogi, P.2    Gross, C.3    Miller, W.L.4
  • 63
    • 12244251426 scopus 로고    scopus 로고
    • Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance
    • Sepilian V, Nagamani M. Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance. J Clin Endocrinol Metab 2005;90:60-5.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 60-65
    • Sepilian, V.1    Nagamani, M.2
  • 64
    • 4043100289 scopus 로고    scopus 로고
    • Effects of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism and ovulatory dysfunction in women with polycystic ovary syndrome
    • Brettenthaler N, De Geyter C, Huber PR, Séller U. Effects of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism and ovulatory dysfunction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:3835-40.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3835-3840
    • Brettenthaler, N.1    De Geyter, C.2    Huber, P.R.3    Séller, U.4
  • 65
    • 0038508940 scopus 로고    scopus 로고
    • Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome
    • Romualdi D, Guido M, Ciampelli M, Giuliani M, Leoni F, Perri C, et al. Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome. Hum Reprod 2003;18:1210-8.
    • (2003) Hum Reprod , vol.18 , pp. 1210-1218
    • Romualdi, D.1    Guido, M.2    Ciampelli, M.3    Giuliani, M.4    Leoni, F.5    Perri, C.6
  • 66
    • 15944390236 scopus 로고    scopus 로고
    • Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome
    • Ortega-González C, Luna S, Hernández L, Crespo G, Aguayo P, Artega-Troncoso G, et al. Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:1360-5.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1360-1365
    • Ortega-González, C.1    Luna, S.2    Hernández, L.3    Crespo, G.4    Aguayo, P.5    Artega-Troncoso, G.6


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