메뉴 건너뛰기




Volumn 88, Issue 5, 2003, Pages 1927-1932

Controversies in endocrinology - A modern medical quandary: Polycystic ovary syndrome, insulin resistance, and oral contraceptive pills

Author keywords

[No Author keywords available]

Indexed keywords

CYPROTERONE ACETATE; DESOGESTREL; METFORMIN; NORETHISTERONE; ORAL CONTRACEPTIVE AGENT; ANTIDIABETIC AGENT;

EID: 0038031022     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021528     Document Type: Review
Times cited : (157)

References (72)
  • 2
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenemic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia
    • Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A 1987 Characterization of groups of hyperandrogenemic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J Clin Endocrinol Metab 65:499-507
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3    Laumas, V.4    Dobrjansky, A.5
  • 3
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A 1989 Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:1165-1174
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 4
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
    • Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257-1266
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Segal, K.R.2    Shelley, D.R.3    Green, G.4    Dobrjansky, A.5    Licholai, T.6
  • 6
    • 0029119085 scopus 로고
    • Excessive insulto receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Xia J, Book CB, Schenker E, Tang Z 1995 Excessive insulto receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 96:801-810
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3    Schenker, E.4    Tang, Z.5
  • 8
    • 0025350772 scopus 로고
    • Impact of obesity on insulin action in volunteers with normal glucose tolerance: Demonstration of a threshold for the adverse effect of obesity
    • Campbell PJ, Gerich JE 1990 Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab 70:1114-1118
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1114-1118
    • Campbell, P.J.1    Gerich, J.E.2
  • 9
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulto resistance in human disease
    • Reaven GM 1988 Banting lecture 1988. Role of insulto resistance in human disease. Diabetes 37:1595-1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 10
    • 0025980368 scopus 로고
    • Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models
    • Reaven GM 1991 Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models. Diabetes Care 14:195-202
    • (1991) Diabetes Care , vol.14 , pp. 195-202
    • Reaven, G.M.1
  • 11
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • The National Cholesterol Education Program (NCEP) Expert Panel 2001 Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). 2001 JAMA 285:2486-2497
    • (2001) 2001 JAMA , vol.285 , pp. 2486-2497
  • 12
    • 0344286476 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome
    • Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J 1999 Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22:141-146
    • (1999) Diabetes Care , vol.22 , pp. 141-146
    • Ehrmann, D.A.1    Barnes, R.B.2    Rosenfield, R.L.3    Cavaghan, M.K.4    Imperial, J.5
  • 13
    • 0032948363 scopus 로고    scopus 로고
    • Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
    • Legro RS, Kunselman AR, Dodson WC, Dunaif A 1999 Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84:165-169
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 165-169
    • Legro, R.S.1    Kunselman, A.R.2    Dodson, W.C.3    Dunaif, A.4
  • 14
    • 0034815278 scopus 로고    scopus 로고
    • Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome
    • Norman RJ, Masters L, Milner CR, Wang JX, Davies MJ 2001 Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Hum Reprod 16:1995-1998
    • (2001) Hum Reprod , vol.16 , pp. 1995-1998
    • Norman, R.J.1    Masters, L.2    Milner, C.R.3    Wang, J.X.4    Davies, M.J.5
  • 16
    • 0035374844 scopus 로고    scopus 로고
    • Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes
    • Peppard HR, Marfori J, Iuorno MJ, Nestler JE 2001 Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes. Diabetes Care 24:1050-1052
    • (2001) Diabetes Care , vol.24 , pp. 1050-1052
    • Peppard, H.R.1    Marfori, J.2    Iuorno, M.J.3    Nestler, J.E.4
  • 17
    • 0033963780 scopus 로고    scopus 로고
    • The prevalence of polycystic ovaries in women with type 2 diabetes mellitus
    • Conn JJ, Jacobs HS, Conway GS 2000 The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin Endocrinol (Oxf) 52:81-86
    • (2000) Clin Endocrinol (Oxf) , vol.52 , pp. 81-86
    • Conn, J.J.1    Jacobs, H.S.2    Conway, G.S.3
  • 18
    • 0029671107 scopus 로고    scopus 로고
    • The android woman - A risky condition
    • Björntorp P 1996 The android woman-a risky condition. J Intern Med 239:105-110
    • (1996) J Intern Med , vol.239 , pp. 105-110
    • Björntorp, P.1
  • 19
    • 0031791823 scopus 로고    scopus 로고
    • High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus
    • Holte J, Gennarelli G, Wide L, Lithell H, Berne C 1998 High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab 83:1143-1150
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1143-1150
    • Holte, J.1    Gennarelli, G.2    Wide, L.3    Lithell, H.4    Berne, C.5
  • 22
    • 0031901117 scopus 로고    scopus 로고
    • Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: Results of a case-control study
    • Talbott E, Clerici A, Berga SL, Kuller L, Guzick D, Detre K, Daniels T, Engberg RA 1998 Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a case-control study. J Clin Epidemiol 51:415-422
    • (1998) J Clin Epidemiol , vol.51 , pp. 415-422
    • Talbott, E.1    Clerici, A.2    Berga, S.L.3    Kuller, L.4    Guzick, D.5    Detre, K.6    Daniels, T.7    Engberg, R.A.8
  • 23
    • 0026603334 scopus 로고
    • Lipid and apolipoprotein abnormalities in hirsute women. I. The association with insulin resistance
    • Wild RA, Alaupovic P, Parker IJ 1992 Lipid and apolipoprotein abnormalities in hirsute women. I. The association with insulin resistance. Am J Obstet Gynecol 166:1191-1196
    • (1992) Am J Obstet Gynecol , vol.166 , pp. 1191-1196
    • Wild, R.A.1    Alaupovic, P.2    Parker, I.J.3
  • 24
    • 0028959137 scopus 로고
    • Obesity, lipids, cardiovascular risk, and androgen excess
    • Wild RA 1995 Obesity, lipids, cardiovascular risk, and androgen excess. Am J Med 98:27S-32S
    • (1995) Am J Med , vol.98
    • Wild, R.A.1
  • 25
    • 0030855145 scopus 로고    scopus 로고
    • Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome
    • Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS 1997 Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 82:2108-2116
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2108-2116
    • Ehrmann, D.A.1    Schneider, D.J.2    Sobel, B.E.3    Cavaghan, M.K.4    Imperial, J.5    Rosenfield, R.L.6    Polonsky, K.S.7
  • 26
    • 0030893613 scopus 로고    scopus 로고
    • Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome
    • Velazquez EM, Mendoza SG, Wang P, Glueck CJ 1997 Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome. Metabolism 46:454-457
    • (1997) Metabolism , vol.46 , pp. 454-457
    • Velazquez, E.M.1    Mendoza, S.G.2    Wang, P.3    Glueck, C.J.4
  • 27
    • 0035702475 scopus 로고    scopus 로고
    • Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
    • Legro RS, Kunselman AR, Dunaif A 2001 Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 111:607-613
    • (2001) Am J Med , vol.111 , pp. 607-613
    • Legro, R.S.1    Kunselman, A.R.2    Dunaif, A.3
  • 28
    • 0034748334 scopus 로고    scopus 로고
    • Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy
    • Diamanti-Kandarakis E, Spina G, Kouli C, Migdalis I 2001 Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy. J Clin Endocrinol Metab 86:4666-4673
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4666-4673
    • Diamanti-Kandarakis, E.1    Spina, G.2    Kouli, C.3    Migdalis, I.4
  • 31
    • 0034734716 scopus 로고    scopus 로고
    • Internal carotid-artery response to 5% carbon dioxide in women with polycystic ovaries
    • Lakhani K, Constantinovici N, Purcell WM, Fernando R, Hardiman P 2000 Internal carotid-artery response to 5% carbon dioxide in women with polycystic ovaries. Lancet 356:1166-1167
    • (2000) Lancet , vol.356 , pp. 1166-1167
    • Lakhani, K.1    Constantinovici, N.2    Purcell, W.M.3    Fernando, R.4    Hardiman, P.5
  • 33
    • 0034455725 scopus 로고    scopus 로고
    • Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome
    • Mather KJ, Verma S, Corenblum B, Anderson TJ 2000 Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome. J Clin Endocrinol Metab 85:1851-1856
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1851-1856
    • Mather, K.J.1    Verma, S.2    Corenblum, B.3    Anderson, T.J.4
  • 35
    • 0027080247 scopus 로고
    • Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women
    • Dahlgren E, Janson PO, Johansson S, Lapidus L, Odén A 1992 Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand 71:599-604
    • (1992) Acta Obstet Gynecol Scand , vol.71 , pp. 599-604
    • Dahlgren, E.1    Janson, P.O.2    Johansson, S.3    Lapidus, L.4    Odén, A.5
  • 37
    • 0031025124 scopus 로고    scopus 로고
    • Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization
    • Birdsall MA, Farquhar CM, White HD 1997 Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Ann Intern Med 126:32-35
    • (1997) Ann Intern Med , vol.126 , pp. 32-35
    • Birdsall, M.A.1    Farquhar, C.M.2    White, H.D.3
  • 38
    • 0028818522 scopus 로고
    • Metabolic effects of oral contraceptives in women with polycystic ovary syndrome
    • Korytkowski MT, Mokan M, Horwitz MJ, Berga SL 1995 Metabolic effects of oral contraceptives in women with polycystic ovary syndrome. J Clin Endocrinol Metab 80:3327-3334
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3327-3334
    • Korytkowski, M.T.1    Mokan, M.2    Horwitz, M.J.3    Berga, S.L.4
  • 39
    • 0030959787 scopus 로고    scopus 로고
    • The effect of a desogestrel-conraining oral contraceptive on glucose tolerance and leptin concentrations in hyperandrogenic women
    • Nader S, Riad-Gabriel MG, Saad MF 1997 The effect of a desogestrel-conraining oral contraceptive on glucose tolerance and leptin concentrations in hyperandrogenic women. J Clin Endocrinol Metab 82:3074-3077
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3074-3077
    • Nader, S.1    Riad-Gabriel, M.G.2    Saad, M.F.3
  • 40
    • 0031789384 scopus 로고    scopus 로고
    • Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome
    • Dahlgren E, Landin K, Krotkiewski M, Holm G, Janson PO 1998 Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome. Hum Reprod 13:2706-2711
    • (1998) Hum Reprod , vol.13 , pp. 2706-2711
    • Dahlgren, E.1    Landin, K.2    Krotkiewski, M.3    Holm, G.4    Janson, P.O.5
  • 41
    • 0033710083 scopus 로고    scopus 로고
    • Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: A randomized study
    • Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Martikainen HK, Tapanainen JS 2000 Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab 85:3161-3168
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3161-3168
    • Morin-Papunen, L.C.1    Vauhkonen, I.2    Koivunen, R.M.3    Ruokonen, A.4    Martikainen, H.K.5    Tapanainen, J.S.6
  • 42
    • 0036063322 scopus 로고    scopus 로고
    • Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: A randomized controlled study
    • Elter K, Imir G, Durmusoglu F 2002 Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study. Hum Reprod 17:1729-1737
    • (2002) Hum Reprod , vol.17 , pp. 1729-1737
    • Elter, K.1    Imir, G.2    Durmusoglu, F.3
  • 43
    • 0037242513 scopus 로고    scopus 로고
    • Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: A randomized study
    • Morin-Papunen L, Vauhkonen I, Koivunen R, Ruokonen A, Martikainen H, Tapanainen JS 2003 Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab 88:148-156
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 148-156
    • Morin-Papunen, L.1    Vauhkonen, I.2    Koivunen, R.3    Ruokonen, A.4    Martikainen, H.5    Tapanainen, J.S.6
  • 46
    • 19244367470 scopus 로고    scopus 로고
    • Acute myocardial infarction and combined oral contraceptives: Results of an international multicentre case-control study
    • WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception 1997 Acute myocardial infarction and combined oral contraceptives: results of an international multicentre case-control study. Lancet 349:1202-1209
    • (1997) Lancet , vol.349 , pp. 1202-1209
  • 49
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bogardus C 1993 Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 329:1988-1992
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6    Knowler, W.C.7    Bogardus, C.8
  • 50
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR 1990 Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 54
    • 0031968394 scopus 로고    scopus 로고
    • Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome
    • Morin-Papunen LC, Koivunen RM, Ruokonen A, Martikainen HK 1998 Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertil Steril 69:691-696
    • (1998) Fertil Steril , vol.69 , pp. 691-696
    • Morin-Papunen, L.C.1    Koivunen, R.M.2    Ruokonen, A.3    Martikainen, H.K.4
  • 55
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ 1994 Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43:647-654
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 56
    • 0033614480 scopus 로고    scopus 로고
    • Ovulatory and metabolic effects of d-chiro-inositol in the polycystic ovary syndrome
    • Nestler JE, Jakubowicz DJ, Reamer P, Gunn R, Allan G 1999 Ovulatory and metabolic effects of d-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 340:1314-1320
    • (1999) N Engl J Med , vol.340 , pp. 1314-1320
    • Nestler, J.E.1    Jakubowicz, D.J.2    Reamer, P.3    Gunn, R.4    Allan, G.5
  • 58
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group 1998 Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 59
    • 0038279359 scopus 로고    scopus 로고
    • Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
    • Johnson JA, Majumdar SR, Simpson SH, Toth EL 2002 Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care 25:2244-2248
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Johnson, J.A.1    Majumdar, S.R.2    Simpson, S.H.3    Toth, E.L.4
  • 60
    • 0020691224 scopus 로고
    • Chronic anovulation syndrome and associated neoplasia
    • Coulam CB, Annegers JF, Kranz JS 1983 Chronic anovulation syndrome and associated neoplasia. Obstet Gynecol 61:403-407
    • (1983) Obstet Gynecol , vol.61 , pp. 403-407
    • Coulam, C.B.1    Annegers, J.F.2    Kranz, J.S.3
  • 61
    • 0026485470 scopus 로고
    • Endometrial cancer associated with polycystic ovaries in young women
    • Smyczek-Gargya B, Geppert M 1992 Endometrial cancer associated with polycystic ovaries in young women. Pathol Res Pract 188:946-948
    • (1992) Pathol Res Pract , vol.188 , pp. 946-948
    • Smyczek-Gargya, B.1    Geppert, M.2
  • 62
    • 0030634987 scopus 로고    scopus 로고
    • Endometrial hyperplasia and the risk of endometrial carcinoma
    • Ho SP, Tan KT, Pang MW, Ho TH 1997 Endometrial hyperplasia and the risk of endometrial carcinoma. Singapore Med J 38:11-15
    • (1997) Singapore Med J , vol.38 , pp. 11-15
    • Ho, S.P.1    Tan, K.T.2    Pang, M.W.3    Ho, T.H.4
  • 65
    • 0026355714 scopus 로고
    • Specific binding sites for insulin and insulin-like growth factor I in human endometrial cancer
    • Nagamani M, Stuart CA, Dunhardt PA, Doherty MG 1991 Specific binding sites for insulin and insulin-like growth factor I in human endometrial cancer. Am J Obstet Gynecol 165:1865-1871
    • (1991) Am J Obstet Gynecol , vol.165 , pp. 1865-1871
    • Nagamani, M.1    Stuart, C.A.2    Dunhardt, P.A.3    Doherty, M.G.4
  • 66
    • 0026550273 scopus 로고
    • Increased steroid production by the ovarian stromal tissue of postmenopausal women with endometrial cancer
    • Nagamani M, Stuart CA, Doherty MG 1992 Increased steroid production by the ovarian stromal tissue of postmenopausal women with endometrial cancer. J Clin Endocrinol Metab 74:172-176
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 172-176
    • Nagamani, M.1    Stuart, C.A.2    Doherty, M.G.3
  • 68
    • 0029029163 scopus 로고
    • Endometrial and ovarian cancer and oral contraceptives - Findings in a large cohort study
    • Vessey MP, Painter R 1995 Endometrial and ovarian cancer and oral contraceptives - findings in a large cohort study. Br J Cancer 71:1340-1342
    • (1995) Br J Cancer , vol.71 , pp. 1340-1342
    • Vessey, M.P.1    Painter, R.2
  • 70
    • 0012650794 scopus 로고    scopus 로고
    • Effects of metformin and rosiglitazone, alone and in combination, in lean women with polycystic ovary syndrome and normal indices of insulin sensitivity
    • San Francisco, CA, (Abstract OR10-1)
    • Baillargeon J, Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Nestler JE Effects of metformin and rosiglitazone, alone and in combination, in lean women with polycystic ovary syndrome and normal indices of insulin sensitivity. Program of the 84th Annual Meeting of The Endocrine Society, San Francisco, CA, 2002, p 78 (Abstract OR10-1)
    • (2002) Program of the 84th Annual Meeting of The Endocrine Society , pp. 78
    • Baillargeon, J.1    Jakubowicz, D.J.2    Iuorno, M.J.3    Jakubowicz, S.4    Nestler, J.E.5
  • 72
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation
    • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M 2000 Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85:139-146
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Perrone, F.5    Caputo, M.6    Zanolin, E.7    Muggeo, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.