Mitochondrial dysfunction is a common phenotype in aging and cancer

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 260-264

  Singh, Keshav K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Aging; Cancer; Mitochondrial dna (mtdna); Mitochondrial dysfunction; Mutation; Osidative stress

Indexed keywords

AGING; BIOACCUMULATION; CANCER; CARCINOGENESIS; CONFERENCE PAPER; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE MUTATION; GENETIC DISORDER; GENOME; HUMAN; LONGEVITY; MOLECULAR BIOLOGY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE;

EID: 3242706786     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.043     Document Type: Conference Paper

References (16)

1. NIH. 2002. Integrating aging and cancer [http://grants1.nih.gov/grants/ guide/pa-files/PA-02-169.html].
2. SINGH, K.K., Ed. 1998. Mitochondrial DNA Mutations in Aging, Disease, and Cancer. Springer Pub. New York.
3. RICHTER, C. 1988. Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett. 241(1-2): 1-5.
4. YAKES, F.M. & B. VAN HOUTEN. 1997. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 94: 514-519.
5. JARUGA, P. & M. DIZDAROGLU. 1996. Repair of products of oxidative DNA base damage in human cells. Nucleic Acids Res. 24: 1389-1394.
6. NAGLEY, P. & C. ZHANG. 1998. Mitochondrial DNA mutations in aging. In Mitochondrial DNA Mutations in Aging, Disease, and Cancer, pp. 205-238. Springer Pub. New York.
7. TANAKA, M. 2002. Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease. J. Neurol. 249(suppl. 2): II11-II18.
8. TANAKA, M., J. GONG, J. ZHANG et al. 2000. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. Mech. Ageing Dev. 116: 65-76.
9. NIEMI, A.K., A. HERVONEN, M. HURME et al. 2003. Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum. Genet. 112: 29-33.
10. FENG, J., F. BUSSIERE & S. HEKIMI. 2001. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1: 633-644.
11. LEE, S.S., R.Y. LEE, A.G. FRASER et al. 2003. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33: 40-48.
12. RASMUSSEN, A.K., A. CHATTERJEE, L.J. RASMUSSEN & K.K. SINGH. 2003. Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. Nucleic Acids Res. 31: 3909-3917.
13. DELSITE, R., S. KACHHAP, R. ANBAZHAGAN et al. 2002. Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells. Mol. Cancer 1(1): 6.
14. KOMINSKY, S.L., P. ARGANI, D. KORZ et al. 2003. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033.
15. MODICA-NAPOLITANO, J. & K.K. SINGH. 2002. Mitochondria as targets for detection and treatment of cancer [http://www-ermm.cbcu.cam.ac.uk/02004453h. htm].
16. SINGH, K.K., J. RUSSELL, B. SIGALA et al. 1999. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene 18: 6641-6646.