Pharmacokinetics of 111In-labeled triplex-forming oligonucleotide targeting human N-myc gene

Molecules and Cells

Volumn 14, Issue 1, 2002, Pages 93-100

  Choe, Jae Gol ^a   Kim, Meyoung Kon ^a   Oh, Eun Jung ^a   Yoon, Eun Jeong ^a   Sohn, Jeongwon ^a   Park, Min Kyu ^a   Park, Gil Hong ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

111In; Breast Carcinoma; N myc; Pharmacokinetics; Triplex forming Oligonucleotide (TFO)

Indexed keywords

INDIUM 111; OLIGONUCLEOTIDE; OLIGONUCLEOTIDE IN 111; RADIOLIGAND; UNCLASSIFIED DRUG; DNA; INDIUM; PENTETIC ACID; TRIPLEX DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOMA; CANCER CELL; CANCER DIAGNOSIS; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG LIVER LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO CULTURE; ISOTOPE LABELING; LEUKEMIA CELL LINE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; OLIGONUCLEOTIDE PROBE; ONCOGENE C MYB; ANIMAL; BAGG ALBINO MOUSE; BREAST TUMOR; CELL CULTURE; FEMALE; METABOLISM; NUDE MOUSE; ONCOGENE MYC;

ANIMALIA; MUS MUSCULUS;

ANIMALS; BREAST NEOPLASMS; DNA; FEMALE; GENES, MYC; HUMANS; INDIUM RADIOISOTOPES; MICE; MICE, INBRED BALB C; MICE, NUDE; OLIGONUCLEOTIDES; PENTETIC ACID; TUMOR CELLS, CULTURED;

EID: 0037206285     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Beal, P. A. and Dervan, P. B. (1991) Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation. Science 251, 1360-1363.
2. Ben-Yosef, T., Yanuka, O., Halle, D., and Benvenisty, N. (1998) Involvement of Myc targets in c-myc and N-myc induced human tumors. Oncogene 17, 165-171.
3. Blume, S. W., Gee, J. E., Shrestha, K., and Miller, D. M. (1992) Triple helix formation by purine-rich oligonucleotides targeted to the human dihydrofolate reductase promoter. Nucleic Acids Res. 20, 1777-1784.
4. Chambery, D., Nohseni-Zadeh, S., Galle, B. D., and Babajko, S. (1999) N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastbma cell line. Cancer Res. 59, 2898-2902.
5. Choi, C. H., Kim, H. S., Rha, H. S., Jeong, J. H., Park, Y. H., MIn, Y. D., Kee, K. H., and Lim, D. Y. (1999) Drug concentration-dependent expression of multidrug resistance-associated protein and P-glycoprotein in the doxorubicin-resistant acute myelogenous leukemia sublines. Mol. Cells 9, 314-319.
6. Cooney, M., Czernuszewicz, G., Postel, E. H., Flint, S. J., and Hogan, M. E. (1988) Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 241, 456-459.
7. Dewanjee, M. K., Ghafouripour, A. K., Kapadvanjwala, M., Dewanjee, S., Serafini, A. N., Lopez, D. M., and Sfakianakis, G. N. (1994) Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J. Nucleic Med. 35, 1054-1063.
8. Durland, R. H., Kessler, D. J., Gunnell, S., Duvic, M., Pettitt, B. M., and Hogan, M. E. (1991) Binding of triple helix forming oligonucleotides to sites in gene promoters. Biochemistry 30, 9246-9255.
9. Durland, R. H., Rao, T. S., Revankar, G. R., Tinsley, J. H., Myrick, M. A., Seth, D. M., Rayford, J., Singh, P., and Jayaraman, K. (1994) Binding of T and T analogs to CG base pairs in antiparallel triplexes. Nucleic Acids Res. 22, 3233-3240.
10. Eilers, M. (1999) Control of cell proliferation by Myc family genes. Mol. Cells 9, 1-6.
11. Frank-Kamenetskii, M. D. and Mirkin, S. M. (1995) Triplex DNA structures. Annu. Rev. Biochem. 64, 65-95.
12. Gazitt, Y., He, Y. J., Chang, L., Koza, S., Fisk, D., and Graham-Pole, J. (1992) Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry. Cancer Res. 52, 2957-2965.
13. Hirose, M. and Kuroda, Y. (1998) p53 may mediate the mdr-1 expression via the VT1 gene in human vincristine-resistant leukemia/lymphoma cell lines. Cancer Lett. 129, 165-171.
14. Hirvonen, H., Hukkanen, V., Salmi, T. T., Pelliniemi, T. T., and Alitalo, R. (1993) L-myc and N-myc in hematopoietic malignancies. Leuk. Lymphoma 11, 197-205.
15. Hoque, A. T., Sedelnikova, O. A., Luu, A. N., Swaim, W. D., Panyutin, I. G., and Baum, B. J. (2000) Use of polyethylenimine-adenovirus complexes to examine triplex formation in intact cells. Antisense Nucleic Acid Drug Dev. 10, 229-241.
16. 111In-labeled oligodeoxyribonucleotides. J. Nucleic Med. 41, 1093-1101.
17. Maher, L. J. 3rd (1992) Inhibition of T7 RNA polymerase initiation by triple-helical DNA complexes: a model for artificial gene repression. Biochemistry 31, 7587-7594.
18. Martin, R. F. and Haseltine, W. A. (1981) Range of radiochemical damage to DNA with decay of iodine-125. Science 213, 896-898.
19. Mayfield, C., Ebbinghaus, S., Gee, J., Jones, D., Rodu, B., Squibb, M., and Miller, D. (1994) Triplex formation by the human Ha-ras promoter inhibits Sp1 binding and in vitro transcription. J. Biol. Chem. 269, 18232-18238.
20. Mizukami, Y., Nonomura, A., Takizawa, T., Noguchi, M., Michigishi, T., Nakamura, S., and Ishizaki, T. (1995) N-myc protein expression in human breast carcinoma: prognostic implications. Anticancer Res. 15, 2899-2905.
21. Nakagawara, A., Kadomatsu, K., Sato, S., Kohno, K., Takano, H., Akazawa, K., Nose, Y., and Kuwano, M. (1990) Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas. Cancer Res. 50, 3043-3047.
22. Panyutin, I. G. and Neumann, R. D. (1994) Sequence-specific DNA double-strand breaks induced by triplex forming 1251 labeled oligonucleotides. Nucleic Acids Res. 22, 4979-4982.
23. Panyutin, I. G. and Neumann, R. D. (1996) Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125. Acta Oncol. 35, 817-823.
24. Panyutin, I. G. and Neumann, R. D. (1997) Radioprobing of DNA: distribution of DNA breaks produced by decay of 125I incorporated into a triplex-forming oligonucleotide correlates with geometry of the triplex. Nucleic Acids Res. 25, 883-887.
25. Pession, A., Trere, D., Perri, P., Rondelli, R., Montanaro, L., Mantovani, W., Derenzini, M., and Paolucci, G. (1997) N-myc amplification and cell proliferation rate in human neuroblastoma. J. Pathol. 183, 339-344.
26. Pilch, D. S., Levenson, C., and Shafer, R. H. (1991) Structure, stability, and thermodynamics of a short intermolecular purine-purine-pyrimidine triple helix. Biochemistry 30, 6081-6088.
27. Prados, J., Melguizo, C., Fernandez, A., Aranega, A. E., Alvarez, L., and Aranega, A. (1996) Inverse expression of mdr 1 and c-myc genes in a rhabdomyosarcoma cell line resistant to actinomycin D. J. Pathol. 180, 85-89
28. Praseuth, D., Guieysse, A. L., and Helene, C. (1999) Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim. Biophys. Acta 1489, 181-206.
29. Sahu, S. K., Kassis, A. I., and Makrigiorgos, G. M. (1995) The effects of indium-111 decay on pBR322DNA. Radiat. Res. 141, 193-198.
30. Sastry, K. S., Howell, R. W., and Rao, D. V. (1988) Dosimetry of Auger emitters: physical and phenomenological approaches; in DNA Damage by Auger Emitters, Baverstock, K. F. and Charlton, D. E. (eds.), pp. 27-38, Taylor & Francis, London.
31. Sedelnikova, O. A., Panyutin, I. G., Luu, A. N., Reed, M. W., Licht, T., Gottesman, M. M., and Neumann, R. D. (2000) Targeting the human mdr1 gene by 125I-labeled triplex-forming oligonucleotides. Antisense Nucleic Acid Drug Dev. 10, 443-452.
32. Sivak, L. E., Pont-Kingdon, G., Le, K., Mayr, G., Tai, K. F., Stevens, B. T., and Carroll, W. L. (1999) A novel intron element operates posttranscriptionally to regulate human N-myc expression. Mol. Cell. Biol. 19, 155-163.