Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 3, 1996, Pages 177-183

  Takakura, Yoshinobu ^a   Mahato, Ram I ^a   Yoshida, Mitsunobu ^a   Kanamaru, Taro ^a   Hashida, Mitsuru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; DEXTRAN SULFATE; OLIGONUCLEOTIDE; POLYINOSINIC ACID;

ANIMAL EXPERIMENT; ARTICLE; LIVER METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; VEIN BLOOD FLOW;

ANIMALIA;

EID: 0029810554     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.177     Document Type: Article

References (5)

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2. AGRAWAL, S., TEMSAMANI, J., and TANG, J.Y. (1991). Pharmacokinetics, biodistribution, and stability of oligonucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88, 7595-7599.
3. BARTON, C.M., and LEMOINE, N.R. (1995). Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression. Br. J. Cancer 71, 429-437.
4. BAYEVER, E., IVERSEN, P., SMITH, L., SPINOLO, J., and ZON, G. (1992). Systemic human antisense therapy begins. Antisense Res. Dev. 2, 109-110.
5. ZON, G. (1988). Oligonucleotide analogues as potential chemotherapeutic agents. Pharm. Res. 5, 539-549.