The complement component C3 plays a critical role in both T H1 and T H2 responses to antigen

Journal of Allergy and Clinical Immunology

Volumn 117, Issue 6, 2006, Pages 1455-1461

  Yalcindag, Ali ^a,b   He, Rui ^a,b   Laouini, Dhafer ^a,b   Alenius, Harri ^a,b   Carroll, Michael ^c   Oettgen, Hans C ^a,b   Geha, Raif S ^a,b  

^a Children's Hospital   (United States)

^b Departments of Pediatrics   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Atopic dermatitis; complement; mouse; T H1; T H2

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ANTIGEN; CD3 ANTIBODY; COMPLEMENT COMPONENT C3; GAMMA INTERFERON; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN ALLERGY; SKIN INFLAMMATION; SKIN SENSITIZATION; SPLEEN CELL; TH1 CELL; TH2 CELL; WILD TYPE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS; CELL PROLIFERATION; CELLS, CULTURED; COMPLEMENT C3; DISEASE MODELS, ANIMAL; FEMALE; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; SPLEEN; TH1 CELLS; TH2 CELLS;

EID: 33646926769     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.01.048     Document Type: Article

References (38)

1. Carroll M.C. The complement system in regulation of adaptive immunity. Nat Immunol 5 (2004) 981-986
2. Carter R.H., and Fearon D.T. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256 (1992) 105-107
3. Fischer W.H., and Hugli T.E. Regulation of B cell functions by C3a and C3a(desArg): suppression of TNF-alpha, IL-6, and the polyclonal immune response. J Immunol 159 (1997) 4279-4286
4. Morgan B.P., Marchbank K.J., Longhi M.P., Harris C.L., and Gallimore A.M. Complement: central to innate immunity and bridging to adaptive responses. Immunol Lett 97 (2005) 171-179
5. Chen A., Gaddipati S., Hong Y., Volkman D.J., Peerschke E.I., and Ghebrehiwet B. Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation. J Immunol 153 (1994) 1430-1440
6. Kawamoto S., Yalcindag A., Laouini D., Brodeur S., Bryce P., Lu B., et al. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest 114 (2004) 399-407
7. Kopf M., Abel B., Gallimore A., Carroll M., and Bachmann M.F. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection. Nat Med 8 (2002) 373-378
8. Nataf S., Davoust N., Ames R.S., and Barnum S.R. Human T cells express the C5a receptor and are chemoattracted to C5a. J Immunol 162 (1999) 4018-4023
9. Tsuji R.F., Kawikova I., Ramabhadran R., Akahira-Azuma M., Taub D., Hugli T.E., et al. Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. J Immunol 165 (2000) 1588-1598
10. Kim A.H., Dimitriou I.D., Holland M.C., Mastellos D., Mueller Y.M., Altman J.D., et al. Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol 173 (2004) 2524-2529
11. Liew F.Y. T(H)1 and T(H)2 cells: a historical perspective. Nat Rev Immunol 2 (2002) 55-60
12. Drouin S.M., Corry D.B., Kildsgaard J., and Wetsel R.A. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. J Immunol 167 (2001) 4141-4145
13. La Flamme A.C., MacDonald A.S., Huxtable C.R., Carroll M., and Pearce E.J. Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis. J Immunol 170 (2003) 470-476
14. Fischer M.B., Ma M., Goerg S., Zhou X., Xia J., Finco O., et al. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol 157 (1996) 549-556
15. Spergel J.M., Mizoguchi E., Brewer J.P., Martin T.R., Bhan A.K., and Geha R.S. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 101 (1998) 1614-1622
16. Ma W., Bryce P.J., Humbles A.A., Laouini D., Yalcindag A., Alenius H., et al. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 109 (2002) 621-628
17. Spergel J.M., Mizoguchi E., Oettgen H., Bhan A.K., and Geha R.S. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103 (1999) 1103-1111
18. Zimmer B., Hartung H.P., Scharfenberger G., Bitter-Suermann D., and Hadding U. Quantitative studies of the secretion of complement component C3 by resident, elicited and activated macrophages. Comparison with C2, C4 and lysosomal enzyme release. Eur J Immunol 12 (1982) 426-430
19. Beuscher H.U., and Brade V. C3 activation by a new factor B-dependent enzyme detected in culture supernatant from guinea-pig peritoneal macrophages. Immunology 58 (1986) 545-551
20. Hetland G., and Eskeland T. Mouse peritoneal macrophages cultured serum-free deposit complement on IgM-coated sheep erythrocytes in vitro. Acta Pathol Microbiol Immunol Scand [C] 95 (1987) 15-20
21. Tengvall P., Askendal A., and Lundstrom I. Studies on protein adsorption and activation of complement on hydrated aluminium surfaces in vitro. Biomaterials 19 (1998) 935-940
22. Applequist S.E., Dahlstrom J., Jiang N., Molina H., and Heyman B. Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes. J Immunol 165 (2000) 2398-2403
23. Hammerberg C., Katiyar S.K., Carroll M.C., and Cooper K.D. Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance. J Exp Med 187 (1998) 1133-1138
24. Yoshida Y., Kang K., Berger M., Chen G., Gilliam A.C., Moser A., et al. Monocyte induction of IL-10 and down-regulation of IL-12 by iC3b deposited in ultraviolet-exposed human skin. J Immunol 161 (1998) 5873-5879
25. Ohkohchi K., Takematsu H., and Tagami H. Determination of anaphylatoxin concentrations in suction blisters in patients with psoriasis. J Invest Dermatol 87 (1986) 65-67
26. Gleich G.J. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 105 (2000) 651-663
27. Horie S., Okubo Y., Hossain M., Sato E., Nomura H., Koyama S., et al. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern Med 36 (1997) 179-185
28. Mochizuki M., Schroder J., Christophers E., and Yamamoto S. IL-4 induces eotaxin in human dermal fibroblasts. Int Arch Allergy Immunol 120 suppl 1 (1999) 19-23
29. Daffern P.J., Pfeifer P.H., Ember J.A., and Hugli T.E. C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation. J Exp Med 181 (1995) 2119-2127
30. Guo R.F., and Ward P.A. Role of c5a in inflammatory responses. Annu Rev Immunol 23 (2005) 821-852
31. Rey-Millet C.A., Villiers C.L., Gabert F.M., Chesne S., and Colomb M.G. C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells. Mol Immunol 31 (1994) 1321-1327
32. Thornton B.P., Vetvicka V., and Ross G.D. Function of C3 in a humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and a primary antigen promotes antigen uptake and the expression of co-stimulatory molecules by all B cells, but only stimulates immunoglobulin synthesis by antigen-specific B cells. Clin Exp Immunol 104 (1996) 531-537
33. Dempsey P.W., Allison M.E., Akkaraju S., Goodnow C.C., and Fearon D.T. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271 (1996) 348-350
34. Kerekes K., Prechl J., Bajtay Z., Jozsi M., and Erdei A. A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells. Int Immunol 10 (1998) 1923-1930
35. Leung D.Y. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105 (2000) 860-876
36. Park J.W., Taube C., Joetham A., Takeda K., Kodama T., Dakhama A., et al. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. Am J Respir Crit Care Med 169 (2004) 726-732
37. Wills-Karp M., and Koehl J. New insights into the role of the complement pathway in allergy and asthma. Curr Allergy Asthma Rep 5 (2005) 362-369
38. Hasegawa K., Tamari M., Shao C., Shimizu M., Takahashi N., Mao X.Q., et al. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hum Genet 115 (2004) 295-301