Q-VD-OPh, next generation caspase inhibitor

Advances in Experimental Medicine and Biology

Volumn 559, Issue , 2005, Pages 293-300

  Brown, Thomas L ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CASPASE INHIBITOR; DACTINOMYCIN; PROTEIN P10; PROTEIN P20;

APOPTOSIS; B LYMPHOCYTE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL VOLUME; CONFERENCE PAPER; CONTROLLED STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING; WHOLE CELL;

EID: 33646888215     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-23752-6_26     Document Type: Conference Paper

References (20)

1. D.R. Plas and CB Thompson, Cell metabolism in the regulation of programmed cell death, Trends Endocrinol Metab. 13, 75-8 (2002).
2. W.C. Earnshaw, L.M. Martins, S.H. Kaufmann, Mammalian caspases: structure, activation, substrates, and functions during apoptosis, Ann Rev Biochem. 68, 383-424 (1999).
3. G.S. Salvesen and V.M. Dixit, Caspases: intracellular signaling by proteolysis, Cell 91, 443-446 (1997).
4. G.M. Cohen, Caspases: the executioners of apoptosis, Biochem. J. 326, 1-16 (1997).
5. T.L. Brown, S. Patil and P.H. Howe, Analysis of TGFβeta-Inducible Apoptosis, In Methods in Molecular Biology -"Transforming growth factor-beta protocols," P. Howe, ed., (Totowa, NJ: Humana Press) 142, 149-67 (2000).
6. J.C. Goldstein, N.J. Waterhouse, P. Juin, G.I. Evan, and D.R. Green, The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant, Nat Cell Biol. 2, 156-62 (2000).
7. X.M. Yin, Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways, Cell Res. 10, 161-7 (2000).
8. M. Fujino, X.K. Li, Y. Kitazawa, L. Guo, M. Kawasaki, N. Funeshima, T. Amano, and S. Suzuki, Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells), J Pharmacol Exp Ther. 300, 939-45 (2002).
9. J.D. Robertson, M. Enoksson, M. Suomela, B. Zhivotovsky, S. Orrenius, Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis, J Biol Chem 277, 9803-9 (2002).
10. T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan, Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta, Nature. 403, 98-103 (2000).
11. R.V. Rao, E. Hermel, S. Castro-Obregon, G. del Rio, L.M. Ellerby, H.M. Ellerby, and D.E. Bredesen, Coupling endoplasmic reticulum stress to the cell death program: Mechanism of caspase activation, J Biol Chem. 276, 33869-74 (2001).
12. H. Fischer, U. Koenig, L. Eckhart, E. Tschachler, Human caspase 12 has acquired deleterious mutation. Biochem Biophys Res Commun. May 3;293(2), 722-6 (2002).
13. P. Schotte, W. Declercq, S. Van Huffel, P. Vandenabeele, and R. Beyaert, Non-specific effects of methyl ketone peptide inhibitors of caspases, FEBS Lett. 442, 117-21 (1999).
14. C.J. Van Noorden, The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition, Acta Histochem. 103, 241-51 (2001).
15. R. Mischak, ICN/ESP Caspase inhibitors: Applications in vivo and in vitro. ICN Bioconcepts 8, 1-5 (2002).
16. T.M. Caserta, A.N. Smith, A.D. Gultice, M.A. Reedy, and TL. Brown, Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties, Apoptosis 8, 345-352 (2003).
17. T.L. Brown, S. Patil, R.K. Basnett, and P.H. Howe, Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition, Cell Growth Diff. 9, 869-875 (1998).
18. T.L. Brown, S. Patil, C.D. Cianci, J.S. Morrow, and P.H. Howe, TGF beta induces caspase 3 independent cleavage of alpha II spectrin (alpha-fodrin) coincident with apoptosis, J. Biol. Chem. 274, 23256-23262 (1999).
19. S.T. Williams, A.N. Smith, C.D. Cianci, J.S. Morrow, and T.L. Brown, Identification of the primary caspase 3 cleavage site in alpha II spectrin during apoptosis, Apoptosis 8, 353-361 (2003).
20. S. Patil, G.M. Wildey, T.L. Brown, L. Choy, R. Derynck, and P.H. Howe, Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta-induced growth inhibition and apoptosis, J Biol Chem. 275, 38363-70 (2000).