Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis

Apoptosis

Volumn 8, Issue 4, 2003, Pages 353-361

  Williams, S T ^a   Smith, A N ^a   Cianci, C D ^b   Morrow, J S ^b   Brown, Thomas L ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actinomycin D; Alpha II spectrin; Apoptosis; Caspase 3

Indexed keywords

ALPHA II SPECTRIN; AMINO ACID; AUTOANTIBODY; CASPASE 3; DACTINOMYCIN; SPECTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DEATH; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVE SITE; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SJOEGREN SYNDROME;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BASE SEQUENCE; CASPASE 3; CASPASES; CELL LINE; DACTINOMYCIN; DNA FRAGMENTATION; HUMANS; IN SITU NICK-END LABELING; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN ISOFORMS; SJOGREN'S SYNDROME; SPECTRIN;

ANIMALIA;

EID: 0042167442     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024168901003     Document Type: Article

References (29)

1. Deng H, Lee JK, Goldstein LS, Branton D. Drosophila development requires spectrin network formation. J Cell Biol 1995; 128: 71-79.
2. Morrow JS, Rimm LD, Kennedy PS, Cianci DC, Sinard HJ, Weed AS. Membrane stability and mosaics: The spectrin cytoskeleton. Handbook of Physiology 1997; 485-540.
3. Haneji N, Nakamura T, Takio K, et al. Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science 1997; 276: 604-607.
4. Inoue H, Tsubota K, Ono M, et al. Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific auto-antigen in Sjögren's syndrome. J Immunol 2001; 166: 5801-5809.
5. Manthrope R, Jacobsson LT, Kirtava Z, Theander E. Epidemiology of Sjögren's syndrome, especially its primary form. Ann Med Interne (Paris) 1998; 149: 7-11.
6. Kerr JF, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
7. King LB, Monroe JG. Immunobiology of the immature B cell: Plasticity in the B-cell antigen receptor-induced response fine tunes negative selection. Immunol Rev 2000; 176: 86-104.
8. Gottschalk RA, Quintans J. Apoptosis in B lymphocytes: The WEHI-231 perspective. Immunology and Cell Biology 1995; 73: 8-16.
9. Plas DR, Thompson CB. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 2002; 13: 75-78.
10. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 1999; 68: 383-424.
11. Salvesen GS, Dixit VM. Caspases: Intracellular signaling by proteolysis. Cell 1997; 91: 443-446.
12. Cohen GM. Caspases: The executioners of apoptosis. Biochem J 1997; 326: 1-16.
13. Faleiro L, Kobayashi R, Fearnhead H, Lazebnik Y. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J 1997; 16: 2271-2281.
14. Brown TL, Patil S, Cianci CD, Morrow JS, Howe PH. TGF beta induces caspase 3 independent cleavage of alpha II-spectrin (alpha-fodrin) coincident with apoptosis. J Biol Chem 1999; 274:23256-23262.
15. Wang KK, Posmantur R, Nath R, et al. Simultaneous degradation of alpha II- and beta II-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 1998; 273: 22490-22497.
16. Yamazaki Y, Tsuruga M, Zhou D, et al. Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. Exp Cell Res 2000; 259: 64-78.
17. Nath R, Huggins M, Glantz SB, et al. Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: Marker for neuronal apoptosis. Neurochem Int 2000; 37: 351-361.
18. Brown TL, Patil S, Howe PH. Analysis of TGFβ-inducible apoptosis. In: Howe P, ed. Methods in Molecular Biology - "Transforming Growth Factor-Beta Protocols. " Totowa, NJ: Humana Press, 2000; 142: 149-167.
19. Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta-induced growth inhibition and apoptosis. J Biol Chem 2000; 275: 38363-38370.
20. Fischer G, Kent SC, Joseph L, Green DR, Scott, DW. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of Myc. J Exp Med 1994; 179: 221-228.
21. Warner GL, Ludlow JW, Nelson DA, Gaur A, Scott DW. Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent. Cell Growth Diff 1992; 3: 175-181.
22. Wu M, Bellas RE, Shen J, Yang W, Sonenshein GE. Increased p27Kip1 cyclin dependent kinase inhibitor gene expression following anti-IgM treatment promotes apoptosis of WEHI 231 B cells. J Immunol 1999; 163: 6530-6535.
23. Wu M, Arsura M, Bellas RE, et al. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol Cell Biol 1996; 16: 5015-5025.
24. Lee JR, Koretzky GA. Extracellular signal-regulated kinase-2, but not c-Jun NH2-terminal kinase, activation correlates with surface IgM-medi-ated apoptosis in the WEHI 231 B cell line. J Immunol 1998; 161: 1637-1644.
25. Fang W, Rivard JJ, Ganser JA, et al. Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol 1995; 155: 66-75.
26. Brown TL, Supriya P, Basnett K, Howe H. Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition. Cell Growth and Differentiation 1998; 9: 869-879.
27. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
28. Kamesaki H, Nishizawa K, Michaud GY, Cossman J, Kiyono T. TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kipl mRNA and protein in murine B cells. J Immunol 1998; 160: 770-777.
29. Takahashi K, Tatsuzawa O, Yanagi K, Hayashi Y, Takahashi H. Alpha-fodrin auto-antibody in Sjogren syndrome and other auto-immune diseases in childhood. Eur J Pediatr 2001; 160: 520-521.