Anabolic effect of prostaglandins

Clinical Reviews in Bone and Mineral Metabolism

Volumn 4, Issue 2, 2006, Pages 123-127

  Raisz, Lawrence G ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Bone formation; COX 2; PGE2; Prostaglandins

Indexed keywords

ARACHIDONIC ACID; CYCLIC AMP; CYCLOOXYGENASE 2; GROWTH FACTOR; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN E1; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT;

ARTICLE; BIOSYNTHESIS; BONE CELL; ENZYME INDUCTION; HUMAN; NONHUMAN; OSSIFICATION; PROSTAGLANDIN SYNTHESIS;

EID: 33646880442     PISSN: 15348644     EISSN: None     Source Type: Journal    
DOI: 10.1385/BMM:4:2:123     Document Type: Article

References (45)

1. Klein DC, Raisz LG. 1970 Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology 86:1436-1440.
2. Blumenkrantz N, Sondergaard J. 1972 Effect of prostaglandins E1 and F1 on biosynthesis of collagen. Nat New Biol 239:246.
3. Raisz LG, Koolemans-Beynen AR. 1974 Inhibition of bone collagen synthesis by prostaglandin E2 in organ culture. Prostaglandins 8:377-385.
4. Scutt A, Zeschnigk M, Bertram P. 1995 PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism. Prostaglandins 49:383-395.
5. Jee WS, Ma YF. 1997 The in vivo anabolic actions of prostaglandins in bone. Bone 21:297-304.
6. Raisz LG, Woodiel FN. 2003 Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures. Prostaglandins Other Lipid Mediat 71:287-292.
7. Paralkar VM, Borovecki F, Ke HZ, et al. 2003 An EP2, receptor-selective prostaglandin E2 agonist induces bone healing. Proc Natl Acad Sci U S A 100:6736-6740.
8. Li M, Ke HZ, Qi H, et al. 2003 A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res 18:2033-2042.
9. Fransen M, Neal B. 2004 Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty. Cochrane Database Syst Rev 3:CD001160.
10. Einhorn TA. 2002 Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 17:977-978.
11. Li M, Ke HZ, Qi H, Healy DR, Li Y, Crawford DT, et al. 2002 Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109: 1405-1415.
12. High WB. 1987 Effects of orally administered prostaglandin E-2 on cortical bone turnover in adult dogs: a histomorphometric study. Bone 8:363-373.
13. Ueda K, Saito A, Nakano H, et al. 1980 Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease. J Pediatr 97:834-836.
14. Faye-Petersen OM, Johnson WH, Jr., Carlo WA, Hedlund G L, Pacifico AD, Blair HC, et al. 1996 Prostaglandin E1-induced hyperostosis: clinicopathologic correlations and possible pathogenetic mechanisms. Pediatr Pathol Lab Med 16: 489-507.
15. Thometz JG, DiRaimondo CA. 1996 A case of recurrent Caffey's disease treated with naproxen. Clin Orthop Relat Res 323:304-309.
16. Gensure RC, Makitie O, Barclay C, et al. 2005 A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. J Clin Invest 115: 1250-1257.
17. Smith WL. 2005 Cyclooxygenases, peroxide tone and the allure of fish oil. Curr Opin Cell Biol 17:174-182.
18. Masuko-Hongo K, Berenbaum F, Humbert L, et al. 2004 Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum 50:2829-2838.
19. Machwate M, Harada S, Leu CT, et al. 2001 Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2). Mol Pharmacol 60:36-41.
20. Hagino H, Kuraoka M, Kameyama Y, Okano T, Teshima R, et al. 2005 Effect of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the cortical bone response to mechanical loading. Bone 36:444-453.
21. Shamir D, Keila S, Weinreb M. 2004 A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin E2 in vivo and in vitro. Bone 34:157-162.
22. Fujieda M, Kiriu M, Mizuochi S, Hagiya K, Kaneki H, Ide H, et al. 1999 Formation of mineralized bone nodules by rat calvarial osteoblasts decreases with donor age due to a reduction in signaling through EP(1) subtype of prostaglandin E(2) receptor. J Cell Biochem 75:215-225.
23. Tang CH, Yang RS, Fu WM. 2005 Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. J Biol Chem 280:22907-22916.
24. Ono K, Kaneko H, Choudhary S, et al. 2005 Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptor. J Bone Miner Res 20:23-29.
25. Soper DL, Milbank JB, Mieling GE, et al. 2001 Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. J Med Chem 44:4157-4169.
26. Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O, Alander CB, Raisz LG, et al. 1993 Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J Biol Chem 268:25643-25649.
27. Raisz LG, Vanderhoek JY, Simmons HA, Kream BE, Nicolaou KC, et al. 1979 Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin. Prostaglandins 17:905-914.
28. Wadhwa S, Godwin SL, Peterson DR, Epstein MA, Raisz LG, Pilbeam CC, et al. 2002 Fluid flow induction of cyclooxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway. J Bone Miner Res 17:266-274.
29. Cherian PP, Siller-Jackson AJ, Gu S, et al. 2005 Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell 16:3100-3106.
30. Bacabac RG, Smit TH, Mullender MG, Dijcks SJ, Van Loon JJ, Klein-Nulend J, et al. 2004 Nitric oxide production by bone cells is fluid shear stress rate dependent. Biochem Biophys Res Commun 315:823-829.
31. Sakuma Y, Li Z, Pilbeam CC, et al. 2004 Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells. Bone 34:827-834.
32. Arikawa T, Omura K, Morita I. 2004 Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells. J Cell Physiol 200:400-406.
33. Paralkar VM, et al. 2002 Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2). J Cell Physiol 190:207-217.
34. Pilbeam C, et al. 1997 Transforming growth factor-beta1 regulation of prostaglandin G/H synthase-2 expression in osteoblastic MC3T3-E1 cells. Endocrinology 138:4672-4682.
35. Paralkar VM, Grasser WA, Mansolf AL, et al. 1997 Induction of cyclooxygenase-2 by parathyroid hormone in human osteoblasts in culture. J Rheumatol 24:2429-2435.
36. Tai H, Miyaura C, Pilbeam CC, et al. 1997 Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation. Endocrinology 138:2372-2379.
37. Yoshida T, Sakamoto H, Horiuchi T, et al. 2001 Involvement of prostaglandin E(2) in interleukin-1 alpha-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis. J Clin Endocrinol Metab 86:3272-3278.
38. Sabbieti MG, Marchetti E, Abreu C, et al. 1999 Prostaglandins regulate the expression of fibroblast growth factor-2 in bone. Endocrinology 140:434-444.
39. Kawaguchi H, Chikazu D, Nakamura K, Kumegawa M, Hakeda Y, et al. 2000 Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures. J Bone Miner Res 15:466-473.
40. Sasaoka R, Terai H, Toyoda H, Imai Y, Sugama R, Takaoka K, et al. 2004 A prostanoid receptor EP4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 318:704-709.
41. Chikazu D, Li X, Kawaguchi H, et al. 2002 Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J Bone Miner Res 17:1430-1440.
42. Raisz LG, Fall PM, Gabbitas BY, McCarthy TL, Kream BE, Canalis E, et al. 1993 Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I. Endocrinology 133:1504-1510.
43. Hakeda Y, Kawaguchi H, Hurley M, et al. 1996 Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonatal mouse calvariae by parathyroid hormone and prostaglandin E2-treatment. J Cell Physiol 166:370-379.
44. Harada S, Nagy JA, Sullivan KA, et al. 1994 Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest 93:2490-2496.
45. Xu M, Choudhary S, Goltzman D, et al. 2005 Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? Endocrinology 146: 1843-1853.