Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5′AMP-activated protein kinase (AMPK) Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique

European Journal of Biochemistry

Volumn 271, Issue 13, 2004, Pages 2831-2840

  Sambandam, Nandakumar ^a   Steinmetz, Michael ^a   Chu, Angel ^a   Altarejos, Judith Y ^a   Dyck, Jason R B ^a   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

AMPK; Cardiac cells; Malonyl CoA decarboxylase

Indexed keywords

5' ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE PHOSPHATE; ANTIBODY; CARBOXYLYASE; GREEN FLUORESCENT PROTEIN; MALONYL COENZYME A; MALONYL COENZYME A DECARBOXYLASE; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; EMBRYO; ENZYME ACTIVITY; GENE DELIVERY SYSTEM; GENE OVEREXPRESSION; GENE TRANSFER; MITOCHONDRION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STATISTICAL SIGNIFICANCE; VIRAL GENETICS;

ADENOVIRIDAE; ADENYLATE KINASE; ANIMALS; CARBOXY-LYASES; CELL LINE; GENE TRANSFER TECHNIQUES; PHOSPHORYLATION; RATS; SUBCELLULAR FRACTIONS;

ADENOVIRIDAE; ANIMALIA;

EID: 3042802322     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04218.x     Document Type: Article

References (43)

1. Hamilton, C. & Saggerson, E.D. (2000) Malonyl-CoA metabolism in cardiac myocytes. Biochem. J. 350, 61-67.
2. McGarry, J.D. & Foster, D.W. (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49, 395-420.
3. McGarry, J.D., Mills, S.E., Long, C.S. & Foster, D.W. (1983) Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues: demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat. Biochem. J. 214, 21-28.
4. Weis, B.C., Esser, V., Foster, D.W. & McGarry, J.D. (1994) Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme. J. Biol. Chem. 269, 18712-18715.
5. Lopaschuk, G.D. (2001) Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron. Artery Dis. 12, S8-S11.
6. Sambandam, N., Lopaschuk, G.D., Brownsey, R.W. & Allard, M.F. (2002) Energy metabolism in the hypertrophied heart. Heart Failure Rev. 7, 161-173.
7. Lopaschuk, G.D., Witters, L.A., Itoi, T., Barr, R. & Barr, A. (1994) Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. J. Biol. Chem. 269, 25871-25878.
8. Kudo, N., Barr, A.J., Barr, R.L., Desai, S. & Lopaschuk, G.D. (1995) High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J. Biol. Chem. 270, 17513-17520.
9. Saddik, M., Gamble, J., Witters, L.A. & Lopaschuk, G.D. (1993) Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J. Biol. Chem. 268, 25836-25845.
10. Sakamoto, J., Barr, R.L., Kavanagh, K.M. & Lopaschuk, G.D. (2000) Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart. Am. J. Physiol. Heart Circ. Physiol. 278, H1196-H1204.
11. Courchesne-Smith, C., Jang, S.H., Shi, Q., DeWille, J., Sasaki, G. & Kolattukudy, P.E. (1992) Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site. Arch. Biochem. Biophys. 298, 576-586.
12. Dyck, J.R., Barr, A.J., Barr, R.L., Kolattukudy, P.E. & Lopaschuk, G.D. (1998) Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation. Am. J. Physiol. 275, H2122-H2129.
13. Dyck, J.R., Berthiaume, L.G., Thomas, P.D., Kantor, P.F., Barr, A.J., Barr, R., Singh, D., Hopkins, T.A., Voilley, N., Prentki, M. & Lopaschuk, G.D. (2000) Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism. Biochem. J. 350, 599-608.
14. Lee, G.Y., Cho, J.W., Lee, H.C. & Kim, Y.S. (2002) Genomic organization and characterization of the promoter of rat malonyl-CoA decarboxylase gene. Biochim. Biophys. Acta 1577, 133-138.
15. Campbell, F.M., Kozak, R., Wagner, A., Altarejos, J.Y., Dyck, J.R., Belke, D.D., Severson, D.L., Kelly, D.P. & Lopaschuk, G.D. (2002) A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J. Biol. Chem. 277, 4098-4103.
16. Saha, A.K., Schwarsin, A.J., Roduit, R., Masse, F., Kaushik, V., Tornheim, K., Prentki, M. & Ruderman, N.B. (2000) Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-amino-imidazole-4-carboxamide-1-beta-D- ribofuranoside. J. Biol. Chem. 275, 24279-24283.
17. Park, H., Kaushik, V.K., Constant, S., Prentki, M., Przybytkowski, E., Ruderman, N.B. & Saha, A.K. (2002) Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J. Biol. Chem. 277, 32571-32577.
18. Hardie, D.G. & Carling, D. (1997) The AMP-activated protein kinase - fuel gauge of the mammalian cell? Eur. J. Biochem. 246, 259-273.
19. Marsin, A.S., Bertrand, L., Rider, M.H., Deprez, J., Beauloye, C., Vincent, M.F., Van den Berghe, G., Carling, D. & Hue, L. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr. Biol. 10, 1247-1255.
20. Kudo, N., Gillespie, J.G., Kung, L., Witters, L.A., Schulz, R., Clanachan, A.S. & Lopaschuk, G.D. (1996) Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim. Biophys. Acta 1301, 67-75.
21. Gamble, J. & Lopaschuk, G.D. (1997) Insulin inhibition of 5′-adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation. Metabolism 46, 1270-1274.
22. Kemp, B.E., Mitchelhill, K.I., Stapleton, D., Michell, B.J., Chen, Z.P. & Witters, L.A. (1999) Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem. Sci. 24, 22-25.
23. Kim, K.H., Lopez-Casillas, F., Bai, D.H., Luo, X. & Pape, M.E. (1989) Role of reversible phosphorylation of acetyl-CoA carboxylase in long-chain fatty acid synthesis. FASEB J. 3, 2250-2256.
24. Park, S.H., Paulsen, S.R., Gammon, S.R., Mustard, K.J., Hardie, D.G. & Winder, W.W. (2002) Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. J. Appl. Physiol. 93, 2081-2088.
25. Habinowski, S.A., Hirshman, M., Sakamoto, K., Kemp, B.E., Gould, S.J., Goodyear, L.J. & Witters, L.A. (2001) Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line. Arch. Biochem. Biophys. 396, 71-79.
26. Lee, G.Y., Bahk, Y.Y. & Kim, Y.S. (2002) Rat malonyl-CoA decarboxylase; cloning, expression in E. coli and its biochemical characterization. J. Biochem. Mol. Biol. 35, 213-219.
27. Mulder, H., Lu, D., Finley, J.T., An, J., Cohen, J., Antinozzi, P.A., McGarry, J.D. & Newgard, C.B. (2001) Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. J. Biol. Chem. 276, 6479-6484.
28. Dyck, J.R. & Lopaschuk, G.D. (1998) Glucose metabolism, H+ production and Na+/H+-exchanger mRNA levels in ischemic hearts from diabetic rats. Mol. Cell Biochem. 180, 85-93.
29. Hardie, D.G., Salt, I.P. & Davies, S.P. (2000) Analysis of the Role of the AMP-Activated Protein Kinase in the Response to Cellular Stress. Humana Press Inc, Totowa, NJ.
30. Gao, J., Waber, L., Bennett, M.J., Gibson, K.M. & Cohen, J.C. (1999) Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. J. Lipid Res. 40, 178-182.
31. He, T.C., Zhou, S. & da Costa, L.T., Yu J., Kinzler, K.W. & Vogelstein, B. (1998) A simplified system for generating recombinant adenoviruses. Proc. Natl Acad. Sci. USA 95, 2509-2514.
32. Sacksteder, K.A., Morrell, J.C., Wanders, R.J., Matalon, R. & Gould, S.J. (1999) MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274, 24461-24468.
33. Woods, A., Azzout-Marniche, D., Foretz, M., Stein, S.C., Lemarchand, P., Ferre, P., Foufelle, F. & Carling, D. (2000) Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol. Cell Biol. 20, 6704-6711.
34. McMillin, J.B., Edgar, K. & Buja, L.M. (1993) Long chain acyl-CoA metabolism by mitochondrial carnitine palmitoyltransferase: A cell model for pathological studies. In Methods in Toxicology, pp. 301-309. Academic Press Inc, San Diego, CA, USA.
35. Rice, J.E. & Lindsay, J.G. (1997) Subcellular fractionation of mitochondria in subcellular fractionation. In A Practical Approach Series (Graham, J.M. & Rickwood, D., eds), pp. 117-118. Oxford University Press, Oxford, UK.
36. Rice, J.E. & Lindsay, J.G. (1997) Subcellular Fractionation of Mitochondria. Oxford University Press, Oxford, UK.
37. Green, D.R. & Reed, J.C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
38. Voilley, N., Roduit, R., Vicaretti, R., Bonny, C., Waeber, G., Dyck, J.R., Lopaschuk, G.D. & Prentki, M. (1999) Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase. Biochem. J. 340 (1), 213-217.
39. Lehman, J.J., Barger, P.M., Kovacs, A., Saffitz, J.E., Medeiros, D.M. & Kelly, D.P. (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106, 847-856.
40. Zong, H., Ren, J.M., Young, L.H., Pypaert, M., Mu, J., Birnbaum, M.J. & Shulman, G.I. (2002) AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc. Natl Acad. Sci. USA 99, 15983-15987.
41. Young, M.E., Goodwin, G.W., Ying, J., Guthrie, P., Wilson, C.R., Laws, F.A. & Taegtmeyer, H. (2001) Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am. J. Physiol. Endocrinol. Metab. 280, E471-E479.
42. Eaton, S. (2002) Control of mitochondrial beta-oxidation flux. Prog. Lipid Res. 41, 197-239.
43. Bavenholm, P.N., Pigon, J., Saha, A.K., Ruderman, N.B. & Efendic, S. (2000) Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes 49, 1078-1083.