Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats

Neuroscience

Volumn 140, Issue 3, 2006, Pages 969-979

  Fang, S H ^a   Wei, E Q ^a   Zhou, Y ^a   Wang, M L ^a   Zhang, W P ^a   Yu, G L ^a   Chu, L S ^a   Chen, Z ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

astrogliosis; cerebral ischemia; cysteinyl leukotriene receptor; cysteinyl leukotriene receptor antagonist; neuronal damage; pranlukast

Indexed keywords

CYSTEINYL LEUKOTRIENE RECEPTOR 1 ANTAGONIST; MESSENGER RNA; PEPTIDOLEUKOTRIENE; PRANLUKAST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN DAMAGE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; GLIA CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; UPREGULATION;

ANIMALS; ASTROCYTES; BRAIN ISCHEMIA; CEREBRAL INFARCTION; CHROMONES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; GLIOSIS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION MEDIATORS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; MALE; MEMBRANE PROTEINS; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEUKOTRIENE; REPERFUSION INJURY; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 33646795009     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.02.051     Document Type: Article

References (43)

1. Baba T., Black K.L., Ikezaki K., Chen K.N., and Becker D.P. Intracarotid infusion of leukotriene C4 selectively increases blood-brain barrier permeability after focal ischemia in rats. J Cereb Blood Flow Metab 11 (1991) 638-643
2. Ballerini P., Di Iorio P., Ciccarelli R., Caciagli F., Poli A., Beraudi A., Buccella S., D'Alimonte I., D'Auro M., Nargi E., Patricelli P., Visini D., and Traversa U. P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia. Int J Immunopathol Pharmacol 18 (2005) 255-268
3. Baskaya M.K., Hu Y., Donaldson D., Maley M., Rao A.M., Prasad M.R., and Dempsey R.J. Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia. J Neurosurg 85 (1996) 112-116
4. Baud L., Perez J., Denis M., and Ardaillou R. Modulation of fibroblast proliferation by sulfidopeptide leukotrienes. effect of indomethacin. J Immunol 138 (1987) 1190-1195
5. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion. evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
6. Black K.L., Hoff J.T., McGillicuddy J.E., and Gebarski S.S. Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans. Ann Neurol 19 (1986) 592-595
7. Brink C., Dahlen S.E., Drazen J., Evans J.F., Hay D.W., Nicosia S., Serhan C.N., Shimizu T., Yokomizo T., and International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev 55 (2003) 195-227
8. Ciccarelli R., D'Alimonte I., Santavenere C., D'Auro M., Ballerini P., Nargi E., Buccella S., NicosiaFolco S., Caciagli F., and Di Iorio P. Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway. Eur J Neurosci 20 (2004) 1514-1524
9. Ciceri P., Rabuffetti M., Monopoli A., and Nicosia S. Production of leukotrienes in a model of focal cerebral ischaemia in the rat. Br J Pharmacol 133 (2001) 1323-1329
10. Danton G.H., and Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62 (2003) 127-136
11. Dhillon H.S., Dose J.M., and Prasad M.R. Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. J Neurotrauma 13 (1996) 781-789
12. Dirnagl U., Simon R.P., and Hallenbeck J.M. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci 26 (2003) 248-254
13. Fagan S.C., Hess D.C., Hohnadel E.J., Pollock D.M., and Ergul A. Targets for vascular protection after acute ischemic stroke. Stroke 35 (2004) 2220-2225
14. Fawcett J.W., and Asher R.A. The glial scar and central nervous system repair. Brain Res Bull 49 (1999) 377-391
15. Henderson W.R.J. The role of leukotrienes in inflammation. Ann Intern Med 121 (1994) 684-697
16. Leikauf G.D., Claesson H.E., Doupnik C.A., Hybbinette S., and Grafstrom R.C. Cysteinyl leukotrienes enhance growth of human airway epithelial cells. Am J Physiol 259 (1990) L255-L261
17. Li Y., Chopp M., Zhang Z.G., and Zhang R.L. Expression of glial fibrillary acidic protein in areas of focal cerebral ischemia accompanies neuronal expression of 72-kDa heat shock protein. J Neurol Sci 128 (1995) 134-142
18. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 79 (1999) 1431-1568
19. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
20. Lynch K.R., O'Neill G.P., Liu Q., Im D.S., Sawyer N., Metters K.M., Coulombe N., Abramovitz M., Figueroa D.J., Zeng Z., Connolly B.M., Bai C., Austin C.P., Chateauneuf A., Stocco R., Greig G.M., Kargman S., Hooks S.B., Hosfield E., Williams D.L.J., Ford-Hutchinson A.W., Caskey C.T., and Evans J.F. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 (1999) 789-793
21. Matsuo M., Hamasaki Y., Fujiyama F., and Miyazaki S. Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures. Brain Res 685 (1995) 201-204
22. Mazzetti L., Franchi-Micheli S., Nistri S., Quattrone S., Simone R., Ciuffi M., Zilletti L., and Failli P. The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. Br J Pharmacol 138 (2003) 707-715
23. Ohd J.F., Nielsen C.K., Campbell J., Landberg G., Lofberg H., and Sjolander A. Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. Gastroenterology 124 (2003) 57-70
24. Ohtsuki T., Matsumoto M., Hayashi Y., Yamamoto K., Kitagawa K., Ogawa S., Yamamoto S., and Kamada T. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. Am J Physiol 268 (1995) H1249-H1257
25. Papadopoulos S.M., Black K.L., and Hoff J.T. Cerebral edema induced by arachidonic acid. role of leukocytes and 5-lipoxygenase products. Neurosurgery 25 (1989) 369-372
26. Persson L., Hardemark H.G., Bolander H.G., Hillered L., and Olsson Y. Neurologic and neuropathologic outcome after middle cerebral artery occlusion in rats. Stroke 20 (1989) 641-645
27. Rao A.M., Hatcher J.F., Kindy M.S., and Dempsey R.J. Arachidonic acid and leukotriene C4. role in transient cerebral ischemia of gerbils. Neurochem Res 24 (1999) 1225-1232
28. Sarau H.M., Ames R.S., Chambers J., Ellis C., Elshourbagy N., Foley J.J., Schmidt D.B., Muccitelli R.M., Jenkins O., Murdock P.R., Herrity N.C., Halsey W., Sathe G., Muir A.I., Nuthulaganti P., Dytko G.M., Buckley P.T., Wilson S., Bergsma D.J., and Hay D.W. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 56 (1999) 657-663
29. Schroeter M., Jander S., and Stoll G. Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels. characterization of inflammatory responses. J Neurosci Methods 117 (2002) 43-49
30. Schuhmann M.U., Mokhtarzadeh M., Stichtenoth D.O., Skardelly M., Klinge P.M., Gutzki F.M., Samii M., and Brinker T. Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. Neurol Res 25 (2003) 481-491
31. Shishido Y., Furushiro M., Hashimoto S., and Yokokura T. Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia. Pharmacol Biochem Behav 69 (2001) 469-474
32. Silver J., and Miller J.H. Regeneration beyond the glial scar. Nat Rev Neurosci 5 (2004) 146-156
33. Simmet T., and Tippler B. Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid. Brain Res 515 (1990) 79-86
34. Sjostrom M., Johansson A.S., Schroder O., Qiu H., Palmblad J., and Haeggstrom J.Z. Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 23 (2003) e37-e41
35. Stoll G., Jander S., and Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56 (1998) 149-171
36. Yano T., Anraku S., Nakayama R., and Ushijima K. Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats. Anesthesiology 98 (2003) 465-473
37. Yonemori F., Yamaguchi T., Yamada H., and Tamura A. Evaluation of a motor deficit after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 18 (1998) 1099-1106
38. Yu G.L., Wei E.Q., Wang M.L., Zhang W.P., Zhang S.H., Weng J.Q., Chu L.S., Fang S.H., Zhou Y., Chen Z., Zhang Q., and Zhang L.H. Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice. Brain Res 1053 (2005) 116-125
39. Yu G.L., Wei E.Q., Zhang S.H., Xu H.M., Chu L.S., Zhang W.P., Zhang Q., Chen Z., Mei R.H., and Zhao M.H. Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. Pharmacology 73 (2005) 31-40
40. Zeng L.H., Zhang W.P., Wang R.D., Wang P.L., and Wei E.Q. [Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice]. Yao Xue Xue Bao 36 (2001) 148-150
41. Zhang R.L., Lu C.Z., Ren H.M., and Xiao B.G. Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Exp Neurol 184 (2003) 746-752
42. Zhang W.P., Hu H., Zhang L., Ding W., Yao H.T., Chen K.D., Sheng W.W., Chen Z., and Wei E.Q. Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors. Neurosci Lett 363 (2004) 247-251
43. Zhang W.P., Wei E.Q., Mei R.H., Zhu C.Y., and Zhao M.H. Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats. Acta Pharmacol Sin 23 (2002) 871-877