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Volumn 37, Issue 1, 2002, Pages 35-44

Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds

(16) Dimmock, Jonathan R a Jha, Amitabh a Kumar, Praveen a Zello, Gordon A a Quail, J Wilson a Oloo, Eliud O a Oucharek, Jennifer J a Pasha, Mohammed K b Seitz, Dallas b Sharma, Rajendra K b Allen, Theresa M c Santos, Cheryl L c Manavathu, Elias K d De Clercq, Erik e Balzarini, Jan e Stables, James P f

a UNIVERSITY OF SASKATCHEWAN (Canada)

b UNIVERSITY OF SASKATCHEWAN (Canada)

c UNIVERSITY OF ALBERTA (Canada)

d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE (United States)

e REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

f NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (United States)

Author keywords

, unsaturated ketones; Cytotoxicity; Mannich bases; N myristoyltransferase; X ray crystallography

Indexed keywords

1,4 BIS(3 DIMETHYLAMINOMETHYL 2 OXO 1 CYCLOHEXYLMETHYLENE)BENZENE; BENZENE DERIVATIVE; KETONE DERIVATIVE; MANNICH BASE; MELPHALAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LYMPHOCYTE; MOUSE; NONHUMAN; TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MANNICH BASES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036181978 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(01)01294-6 Document Type: Article

Times cited : (19)

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