An antibody produced in tobacco expressing a hybrid β-1,4- galactosyltransferase is essentially devoid of plant carbohydrate epitopes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 20, 2006, Pages 7577-7582

  Bakker, Hans ^a,f   Rouwendal, Gerard J A ^a   Karnoup, Anton S ^b   Florack, Dion E A ^a   Stoopen, Geert M ^a   Helsper, Johannes P F G ^a   Van Ree, Ronald ^c   Van Die, Irma ^d   Bosch, Dirk ^a,e  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b DOW CHEMICAL COMPANY   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Biopharmaceutical; Glycosylation; Immunogenicity

Indexed keywords

ANTIBODY; BETA 1,4 GALACTOSYLTRANSFERASE; CARBOHYDRATE; EPITOPE; FUCOSE; GALACTOSE; GALACTOSYLTRANSFERASE; GLYCAN DERIVATIVE; MONOCLONAL ANTIBODY; TRANSFERASE; UNCLASSIFIED DRUG; XYLOSE; XYLOSYLTRANSFERASE;

AMINO TERMINAL SEQUENCE; ARABIDOPSIS; ARTICLE; ENZYME ACTIVE SITE; GLYCOSYLATION; HYBRID; IMMUNOGENICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION; RADIOALLERGOSORBENT TEST; TOBACCO; TRANSGENIC PLANT; WESTERN BLOTTING;

ANTIBODIES; ARABIDOPSIS; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; EPITOPES; GALACTOSYLTRANSFERASES; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN E; MICROSOMES; MOLECULAR SEQUENCE DATA; N-ACETYLLACTOSAMINE SYNTHASE; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; POLYSACCHARIDES; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TOBACCO; TRANSFORMATION, GENETIC;

ARABIDOPSIS THALIANA; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 33646737444     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600879103     Document Type: Article

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