Oral mucositis

Oral Diseases

Volumn 12, Issue 3, 2006, Pages 229-241

  Scully, C ^a   Sonis, S ^b   Diz, P D ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cancer; Chemotherapy; Mucositis; Oral; Radiotherapy

Indexed keywords

ACETYLCYSTEINE; ACICLOVIR; ALLOPURINOL; ALUMINUM MAGNESIUM HYDROXIDE; AMIFOSTINE; AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; APOPTOSIS INHIBITOR; AZELASTINE; BENZYDAMINE; BIOLOGICAL RESPONSE MODIFIER; CHLORHEXIDINE; CLOPIDOGREL; CYCLOOXYGENASE 2 INHIBITOR; DESIPRAMINE; DIPHENHYDRAMINE; FLUCONAZOLE; GLUTAMINE; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 11; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR 1; MANGANESE SUPEROXIDE DISMUTASE; MELILOTUS EXTRACT; PALIFERMIN; POVIDONE; PROSTAGLANDIN E2; PROTEGRIN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BACTEREMIA; CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL FEATURE; CLINICAL TRIAL; CRYOTHERAPY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; DRUG USE; FUNGEMIA; GINGIVITIS; GRAFT VERSUS HOST REACTION; HEALTH CARE COST; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFECTION; MUCOSA INFLAMMATION; NECROTIZING GINGIVITIS; NEUTROPENIA; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; QUALITY OF LIFE; RADIATION DOSE; REVIEW; RISK FACTOR; SEPTICEMIA;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; BACTERIAL INFECTIONS; BENZYDAMINE; CRANIAL IRRADIATION; CRYOTHERAPY; CYTOKINES; FIBROBLAST GROWTH FACTOR 7; FREE RADICALS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MOUTHWASHES; MUCOSITIS; MYCOSES; QUALITY OF LIFE; STOMATITIS;

EID: 33646681237     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2006.01258.x     Document Type: Review

References (183)

1. Adamietz IA Rahn R Bottcher HD Schafer V Reimer K Fleischer W 1998 Prophylaxis with povidone-iodine against induction of oral mucositis by radiochemotherapy Support Care Cancer 6 373 377
2. Ahmed T Engelking C Szalyga J et al 1993 Propantheline prevention of mucositis from etoposide Bone Marrow Transplant 12 131 132
3. Allison RR Vongtama V Vaughan J Shin KH 1995 Symptomatic acute mucositis can be minimized or prophylaxed by the combination of sucralfate and fluconazole Cancer Invest 13 16 22
4. Anderson PM Ramsay NK Shu XO et al 1998a Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation Bone Marrow Transplant 22 339 344
5. Anderson PM Schroeder G Skubitz KM 1998b Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy Cancer 83 1433 1439
6. Atkinson K Biggs JC Downs K et al 1991 GM-CSF after allogeneic bone marrow transplantation: accelerated recovery of neutrophils, monocytes and lymphocytes Aust N Z J Med 21 686 692
7. Attal M Huguet F Rubie H et al 1993 Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial Blood 82 732 736
8. Awada A Genot MT Klastersky J 2005 Palifermin and chemotherapy-induced oral mucositis N Engl J Med 352 1264 1265 author reply
9. Awidi A Homsi U Kakail RI et al 2001 Double-blind, placebo-controlled cross-over study of oral pilocarpine for the prevention of chemotherapy-induced oral mucositis in adult patients with cancer Eur J Cancer 37 2010 2014
10. Balis FM Savitch JL Bleyer WA Reaman GH Poplack DG 1985 Remission induction of meningeal leukemia with high-dose intravenous methotrexate J Clin Oncol 3 485 489
11. Barasch A Peterson DE Tanzer JM et al 1995a Helium-neon laser effects on conditioning-induced oral mucositis in bone marrow transplantation patients Cancer 76 2550 2556
12. Barasch A Peterson DE Tanzer JM et al 1995b Helium-neon laser effects on conditioning-induced oral mucositis in bone marrow transplantation patients Cancer 76 2550 2556
13. Barrett AP 1987 A long-term prospective clinical study of oral complications during conventional chemotherapy for acute leukemia Oral Surg Oral Med Oral Pathol 63 313 316
14. Bellm LA Epstein JB Rose-Ped A Martin P Fuchs HJ 2000 Patient reports of complications of bone marrow transplantation Support Care Cancer 8 33 39
15. Bensadoun RJ Franquin JC Ciais G et al 1999 Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer Support Care Cancer 7 244 252
16. Berger A Henderson M Nadoolman W et al 1995 Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy J Pain Symptom Manage 10 243 248
17. Bergmann OJ 1988 Oral infections and septicemia in immunocompromised patients with hematologic malignancies J Clin Microbiol 26 2105 2109
18. Bergmann OJ 1989 Oral infections and fever in immunocompromised patients with haematologic malignancies Eur J Clin Microbiol Infect Dis 8 207 213
19. Bianco JA Appelbaum FR Nemunaitis J et al 1991 Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation Blood 78 1205 1211
20. Bishop JF Joshua DE Lowenthal RM et al 1986 A phase I-II study of cytosine arabinoside, daunorubicin, and VP16-213 in adult patients with acute non-lymphocytic leukemia Aust N Z J Med 16 48 51
21. Blijlevens NM Donnelly JP De Pauw BE 2000 Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview Bone Marrow Transplant 25 1269 1278
22. Bondi E Baroni C Prete A et al 1997 Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation Oral Oncol 33 322 326
23. Borowski B Benhamou E Pico JL Laplanche A Margainaud JP Hayat M 1994 Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care Eur J Cancer B Oral Oncol 30B 93 97
24. Brizel DM Wasserman TH Henke M et al 2000 Phase III randomized trial of amifostine as a radioprotector in head and neck cancer J Clin Oncol 18 3339 3345
25. Brown AT Shupe JA Sims RE et al 1990 In vitro effect of chlorhexidine and amikacin on oral Gram-negative bacilli from bone marrow transplant recipients Oral Surg Oral Med Oral Pathol 70 715 719
26. Caballero GA Ausman RK Quebbeman EJ 1985 Long-term, ambulatory, continuous IV infusion of 5-FU for the treatment of advanced adenocarcinomas Cancer Treat Rep 69 13 15
27. Capelli D Santini G De Souza C et al 2000 Amifostine can reduce mucosal damage after high-dose melphalan conditioning for peripheral blood progenitor cell autotransplant: a retrospective study Br J Haematol 110 300 307
28. Carl W Higby DJ 1985 Oral manifestations of bone marrow transplantation Am J Clin Oncol 8 81 87
29. Cascinu S Fedeli A Fedeli SL Catalano G 1994 Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis Eur J Cancer B Oral Oncol 30B 234 236
30. Chen J Falla TJ Liu H et al 2000 Development of protegrins for the treatment and prevention of oral mucositis: structure-activity relationships of synthetic protegrin analogues Biopolymers 55 88 98
31. Cheng KK 2004 Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis Eur J Oncol Nurs 8 341 349
32. Chi KH Chen CH Chan WK et al 1995 Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy J Clin Oncol 13 2620 2628
33. Ciais G Namer M Schneider M et al 1992 Laser therapy in the prevention and treatment of mucositis caused by anticancer chemotherapy Bull Cancer 79 183 191
34. Clark PI Slevin ML 1985 Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity Eur J Surg Oncol 11 267 268
35. Clarkson A 2003 Cochrane Database Syst Rev CD000978
36. Clarkson JE Worthington HV Eden OB 2000 Prevention of oral mucositis or oral candidiasis for patients with cancer receiving chemotherapy (excluding head and neck cancer) Cochrane Database Syst Rev CD000978
37. Classen DC Burke JP Ford CD et al 1990 Streptococcus mitis sepsis in bone marrow transplant patients receiving oral antimicrobial prophylaxis Am J Med 89 441 446
38. Clift RA Bianco JA Appelbaum FR et al 1993 A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation Blood 82 2025 2030
39. Cohen G Elad S Or R Galili D Garfunkel AA 1997 The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study Oral Dis 3 243 246
40. Cowen D Tardieu C Schubert MM et al 1997 Low energy helium-neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: results of a double blind randomized trial Int J Radiat Oncol Biol Phys 38 697 703
41. Crawford J O'Rourke MA 1994 Vinorelbine (Navelbine)/carboplatin combination therapy: dose intensification with granulocyte colony-stimulating factor Semin Oncol 21 5 Suppl. 10 73 78
42. Crawford J Tomita DK Mazanet R et al 1999 Reduction of oral mucositis by filgrastim 9r-met HUG-CFF) in patients receiving chemotherapy Cytokines Cell Mol Ther 5 187 193
43. Dahllof G Heimdahl A Modeer T Twetman S Bolme P Ringden O 1989 Oral mucous membrane lesions in children treated with bone marrow transplantation Scand J Dent Res 97 268 277
44. Dodd MJ Dibble SL Miaskowski C et al 2000 Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90 39 47
45. Donnelly JP 1993 Selective decontamination of the digestive tract and its role in antimicrobial prophylaxis J Antimicrob Chemother 31 813 829
46. Donnelly JP Muus P Schattenberg A De Witte T Horrevorts A DePauw BE 1992 A scheme for daily monitoring of oral mucositis in allogeneic BMT recipients Bone Marrow Transplant 9 409 413
47. Donnelly JP Dompeling EC Meis JF De Pauw BE 1995 Bacteremia due to oral viridans streptococci in neutropenic patients with cancer: cytostatics are a more important risk factor than antibacterial prophylaxis Clin Infect Dis 20 469 470
48. Donnelly JP Bellm LA Epstein JB et al 2003 Antimicrobial therapy to prevent or treat oral mucositis Lancet infect Dis 3 405 412
49. Dorr W Jacubek A Kummermehr J Herrmann T Dolling-Jochem I Eckelt U 1995 Effects of stimulated repopulation on oral mucositis during conventional radiotherapy Radiother Oncol 37 100 107
50. Dreizen S McCredie KB Bodey GP Keating MJ 1986 Quantitative analysis of the oral complications of antileukemia chemotherapy Oral Surg Oral Med Oral Pathol 62 650 653
51. Duenas-Gonzalez A Sobrevilla-Calvo P Frias-Mendivil M et al 1996 Misoprostol prophylaxis for high-dose chemotherapy-induced mucositis: a randomized double-blind study Bone Marrow Transplant 17 809 812
52. Dumontet C Sonnet A Bastion Y Salles G Espinouse D Coiffier B 1994 Prevention of high dose L-PAM-induced mucositis by cryotherapy Bone Marrow Transplant 14 492 494
53. Duncan GG Epstein JB Tu D et al 2005 Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis Head Neck 27 421 428
54. Durant JR 1999 High-dose chemotherapy for breast cancer in USA Lancet 354 252 253
55. Edelman MJ Gandara Dr Perez EA et al 1998 Phase 1 trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy Invest New Drugs 16 69 75
56. Edwards JE Jr. Bodey GP Bowden RA et al 1997 International conference for the development of a consensus on the management and prevention of severe candidal infections Clin Infect Dis 25 43 59
57. Elting LS Bodey GP Keefe BH 1992 Septicemia and the shock syndrome due to Viridans streptococci: a case control study of predisposing factor Clin Infect Dis 14 1201 1207
58. Elting LS Cooksley C Chambers M Cantor SB Manzullo E Rubenste EB 2003 The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis Cancer 14 1201 1207
59. Epstein JB Wong FL 1994 The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy Int J Radiat Oncol Biol Phys 28 693 698
60. Epstein JB Silverman S Paggiarino DA et al 2001 Benzydamine HCI for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled trial Cancer 92 875 885
61. Epstein JB Stevenson-Moore P Jackson S Mohamed JH Spinelli JJ 1989 Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse Int J Radiat Oncol Biol Phys 16 1571 1575
62. Epstein JB Vickars L Spinelli J Reece D 1992 Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation Oral Surg Oral Med Oral Pathol 73 682 689
63. Etiz D Erkal HS Serin M et al 2000 Clinical and histopathological evaluation of sucralfate in prevention of oral mucositis induced by radiation therapy in patients with head and neck malignancies Oral Oncol 36 116 120
64. Farrell CL Rex KL Chen JN 2002 The effects of keratinocyte growth factor in preclinical models of mucositis Cell Prolif 35 Suppl. 1 S78 S85
65. Feld R 1997 The role of surveillance cultures in patients likely to develop chemotherapy-induced mucositis Support Care Cancer 5 371 375
66. Ferretti GA Ash RC Brown AT Largent BM Kaplan A Lillich TT 1987 Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants J Am Dent Assoc 114 461 467
67. Ferretti GA Ash RC Brown AT Parr MD Romond EH Lillich TT 1988 Control of oral mucositis and candidiasis in marrow transplantation: a prospective, double-blind trial of chlorhexidine digluconate oral rinse Bone Marrow Transplant 3 483 493
68. Ferretti GA Raybould TP Brown AT et al 1990 Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial Oral Surg Oral Med Oral Pathol 69 331 338
69. Fidler P Loprinzi CL O'Fallon JR et al 1996 Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis Cancer 77 522 525
70. Foote RL Loprinzi CL Frank AR et al 1994 Randomised trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis J Clin Oncol 12 2630 2633
71. Franzen L Henriksson R Littbrand B Zackrisson B 1995 Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study Acta Oncol 34 219 223
72. Gabrilove JL Jakubowski A Scher H et al 1988 Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium N Engl J Med 318 1414 1422
73. Garfunkel AA 2004 Oral mucositis-the search for a solution N Engl J Med 351 2649 2651
74. Garfunkel AA Tager N Chausu S Chausu G Haze C Galili D 1994 Oral complications in bone marrow transplantation patients: recent advances Isr J Med Sci 30 120 124
75. Genot MT Klastersky J 2005 Low-level laser for prevention and therapy of oral mucositis induced by chemotherapy or radiotherapy Curr Opin Oncol 17 236 240
76. Gordon B Spadinger A Hodges E Ruby E Stanley R Coccia P 1994 Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis after hematopoietic stem-cell transplantation J Clin Oncol 12 1917 1922
77. Greenberg MS Cohen SG McKitrick JC Cassileth PA 1982 The oral flora as a source of septicemia in patients with acute leukemia Oral Surg Oral Med Oral Pathol 53 32 36
78. Grotz KA Henneicke-von Zepelin HH Kohnen R et al 1999 Prospective double-blind study of prophylaxis of radioxerostomia with Coumarin/Troxerutine in patients with head and neck cancer Strahlenther Onkol 175 397 403
79. Grotz KA Wustenberg P Kohnen R et al 2001 Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer - a prospective, randomized, placebo-controlled, double-blind study Br J Oral Maxillofac Surg 39 34 39
80. Gujral MS Patnaik PM Kaul R et al 2001 Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers Cancer Chemother Pharmacol 47 Suppl. S23 S28
81. Guo H Seixas-Silva JA Jr. Epperly MW et al 2003 Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene Radiat Res 159 361 370
82. Herrstedt J 2000 Prevention and management of mucositis in patients with cancer Int J Antimicrob Agents 16 161 163
83. Hickey AJ Toth BB Lindquist SB 1982 Effect of intravenous hyperalimentation and oral care on the development of oral stomatitis during cancer chemotherapy J Prosthet Dent 47 188 193
84. Ibrahim EM al Mulhim FA 1997 Effect of granulocyte-macrophage colony-stimulating factor on chemotherapy-induced oral mucositis in non-neutropenic cancer patients Med Oncol 14 47 51
85. Kannan V Bapsy PP Anantha N et al 1997 Efficacy and safety of granulocyte macrophage-colony stimulating factor (GM-CSF) on the frequency and severity of radiation mucositis in patients with head and neck carcinoma Int J Radiat Oncol Biol Phys 37 1005 1010
86. Karthaus M Rosenthal C Huebner G et al 1998 Effect of topical oral G-CSF on oral mucositis: a randomised placebo-controlled trial Bone Marrow Transplant 22 781 785
87. Kim JH Chu FC Lakshmi V Houde R 1986 Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx Am J Clin Oncol 9 132 134
88. Kostler WJ Hejna M Zielinski CC 2005 Palifermin and chemotherapy-induced oral mucositis N Engl J Med 352 1264 1265 author reply
89. Koukourakis MI 2002 Amifostine in clinical oncology: current use and future applications Anticancer Drugs 13 181 209
90. Krijanovski OI Hill GR Cooke KR et al 1999 Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease Blood 94 825 831
91. Kuhrer I Kuzmits R Linkesch W Ludwig H 1986 Topical PGE2 enhances healing of chemotherapy-associated mucosal lesions Lancet 1 623
92. Labar B Mrsic M Pavletic Z et al 1993 Prostaglandin E2 for prophylaxis of oral mucositis following BMT Bone Marrow Transplant 11 379 382
93. Laine PO Lindqvist JC Pyrhonen SO Strand-Pettinen IM Teerenhovi LM Meurman JH 1992 Oral infection as a reason for febrile episodes in lymphoma patients receiving cytostatic drugs Eur J Cancer B Oral Oncol 28B 103 107
94. Lalla RV Peterson DE 2005 Oral mucositis Dent Clin North Am 49 167 184
95. van der Lelie H Thomas BL van Oers RH et al 2001 Effect of locally applied GM-CSF on oral mucositis after stem cell transplantation: a prospective placebo-controlled double-blind study Ann Hematol 80 150 154
96. Levy-Polack MP Sebelli P Polack NL 1998 Incidence of oral complications and application of a preventive protocol in children with acute leukemia Spec Care Dentist 18 189 193
97. Lockhart PB Brennan MT Kent ML et al 2005 Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantation Bone Marrow Transplant 35 713 20
98. Lopez I Goudou C Ribrag V Sauvage C Hazebroucq G Dreyfus F 1994 Treatment of mucositis with vitamin E during administration of neutropenic antineoplastic agents Ann Med Interne (Paris) 145 405 408
99. Loprinzi CL Cianflone SG Dose AM et al 1990 A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis Cancer 65 1879 1882
100. Loprinzi CL Ghosh C Camoriano J et al 1997 Phase III controlled evaluation of sucralfate to alleviate stomatitis in patients receiving fluorouracil-based chemotherapy J Clin Oncol 15 1235 1238
101. Lucas VS Beighton D Roberts GJ Challacombe SJ 1997 Changes in the oral streptococcal flora of children undergoing allogeneic bone marrow transplantation J Infect 35 135 141
102. MacBurney M Young LS Ziegler TR Wilmore DW 1994 A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplant patients J Am Diet Assoc 94 1263 1266
103. Maciejewski B Zajusz A Pilecki B et al 1991 Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head and neck cancer Radiother Oncol 22 7 11
104. Magrath IT Janus C Edwards BK et al 1984 An effective therapy for both undifferentiated (including Burkitt's) lymphomas and lymphoblastic lymphomas in children and young adults Blood 63 1102 1111
105. Mahood DJ Dose AM Loprinzi CL et al 1991 Inhibition of fluorouracil-induced stomatitis by oral cryotherapy J Clin Oncol 9 449 452
106. Martin MV 1993 Irradiation mucositis: a reappraisal Eur J Cancer B Oral Oncol 29B 1 2
107. Mascarin M Franchin G Minatel E et al 1999 The effect of granulocyte colony-stimulating factor on oral mucositis in head and neck cancer patients treated with hyperfractionated radiotherapy Oral Oncol 35 203 208
108. Matejka M Nell A Kment G et al 1990 Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis Br J Oral Maxillofac Surg 28 89 91
109. Mazokopakis EE Vrentzos GE Papadakis JA Babalis DE Ganotakis ES 2005 Wild chamomile (Matricaria recutita L.) mouthwashes in methotrexate-induced oral mucositis Phytomedicine 12 25 27
110. McCarthy GM Skillings JR 1992 Orofacial complications of chemotherapy for breast cancer Oral Surg Oral Med Oral Pathol 74 172 178
111. Mead GM 2002 Management of oral mucositis associated with cancer chemotherapy Lancet 359 815 816
112. Meloni G Capria S Proia A Trisolini SM Mandelli F 1996 Ice pops to prevent melphalan-induced stomatitis Lancet 347 1691 1692
113. Nakamura K Natsugoe S Kumanohoso T et al 1996 Prophylactic action of allopurinol against chemotherapy-induced stomatitis - inhibition of superoxide dismutase and proteases Anticancer Drugs 7 235 239
114. Nemunaitis J Rosenfeld CS Ash R et al 1995 Phase III randomized, double-blind placebo-controlled trial of rhGM-CSF following allogeneic bone marrow transplantation Bone Marrow Transplant 15 949 954
115. Nes AG Posso MB 2005 Patients with moderate chemotherapy-induced mucositis: pain therapy using low intensity lasers Int Nurs Rev 52 68 72
116. Nikoletti S Hyde S Shaw T Myers H Kristjanson LJ 2005 Comparison of plain ice and flavoured ice for preventing oral mucositis associated with the use of 5 fluorouracil J Clin Nurs 14 750 753
117. Oblon DJ Paul SR Oblon MB Malik S 1997 Propantheline protects the oral mucosa after high-dose ifosfamide, carboplatin, etoposide and autologous stem cell transplantation Bone Marrow Transplant 20 961 963
118. Orazi A Du X Yang Z Kashai M Williams DA 1996 Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation Lab Invest 75 33 42
119. Palmieri C Vigushin D 2005 Palifermin and chemotherapy-induced oral mucositis N Engl J Med 352 1264 1265 author reply
120. Parulekar W Mackenzie R Bjarnason G Jordan RC 1998 Scoring oral mucositis Oral Oncol 34 63 71
121. Perch SJ Machtay M Markiewicz DA Kligerman MM 1995 Decreased acute toxicity by using midline mucosa-sparing blocks during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx Radiology 197 863 866
122. Peterson DE 2006 New strategies for management of oral mucositis in cancer patients J Support Oncol 4 9 13
123. Pico JL Avila-Garavito A Naccache P 1998 Mucositis: its occurrence, consequences, and treatment in the oncology setting Oncologist 3 446 451
124. Porta C Moroni M Nastasi G 1994 Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis Am J Clin Oncol 17 246 247
125. Potten CS 1996 Protection of the small intestinal clonogenic stem cells from radiation-induced damage by pretreatment with interleukin 11 also increases murine survival time Stem Cells (Dayt) 14 452 459
126. Rahn R Adamietz IA Boettcher HD Schaefer V Reimer K Fleischer W 1997 Povidone-iodine to prevent mucositis in patients during antineoplastic radiochemotherapy Dermatology 195 Suppl. 2 57 61
127. Rapoport AP Miller Watelet LF Linder T et al 1999 Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants J Clin Oncol 17 2446 2453
128. Rice DH Gill G 1979 The effect of irradiation upon the bacterial flora in patients with head and neck cancer Laryngoscope 89 1839 1841
129. Rocke LK Loprinzi CL Lee JK et al 1993 A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil- related stomatitis Cancer 72 2234 2238
130. Rodu B Gockerman JP 1983 Oral manifestations of the chronic graft-v-host reaction JAMA 249 504 507
131. Rosso M Blasi G Gherlone E Rosso R 1997 Effect of granulocyte-macrophage colony-stimulating factor on prevention of mucositis in head and neck cancer patients treated with chemo-radiotherapy J Chemother 9 382 385
132. Roth BJ Sledge GW Jr. Williams SD Meyer SC Ansari R Fisher WB 1991 Methotrexate, vinblastine, doxorubicin, and cisplatin in metastatic breast cancer. A phase II trial of the Hoosier Oncology Group Cancer 68 248 252
133. Rubenstein EB Peterson DE Schubert M Keefe D et al 2004 Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis Cancer 100 Suppl. 2026 2046
134. Ruescher TJ Sodeifi A Scrivani SJ Kaban LB Sonis ST 1998 The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies Cancer 82 2275 2281
135. Samaranayake LP Robertson AG MacFarlane TW et al 1988 The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation Clin Radiol 39 291 294
136. Schloerb PR Skikne BS 1999 Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study JPEN J Parenter Enteral Nutr 23 117 122
137. Schubert MM Sullivan KM Morton TH et al 1984 Oral manifestations of chronic graft-v-host disease Arch Intern Med 144 1591 1595
138. Scully C Epstein J Sonis S 2003 Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 1, pathogenesis and prophylaxis of mucositis Head Neck 25 1057 1070
139. Scully C Epstein J Sonis S 2004 Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2, diagnosis and management of mucositis Head Neck 26 77 84
140. Ship JA Eisbruch A D'Hondt E Jones RE 1997 Parotid sparing study in head and neck cancer patients receiving bilateral radiation therapy: one-year results J Dent Res 76 807 813
141. Sinzinger H Porteder H Matejka M Peskar BA 1989 Prostaglandins in irradiation-induced mucositis Lancet 1 556
142. Sironi M Milanese C Vecchi A et al 1997 Benzydamine inhibits the release of tumor necrosis factor-alpha and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells Int J Clin Lab Res 27 118 122
143. Sonis ST 1998 Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity Oral Oncol 34 39 43
144. Sonis ST 2002 The biologic role of nuclear factor-κβ in disease and its potential involvement in mucosal injury associated with antineoplastic therapy Crit Rev Oral Biol Med 13 300 309
145. Sonis ST 2004a The pathobiology of mucositis Nat Rev Cancer 4 277 284
146. Sonis ST 2004b Pathobiology of mucositis Semin Oncol Nursing 20 11 15
147. Sonis ST Fey EG 2002 Oral complications of cancer therapy Oncology 16 680 686
148. Sonis HT Haley JD 1996 Pharmcological attenuation of chemotherapy-induced oral mucositis Exp Opinon Invest Drugs 5 1155 1162
149. Sonis S Kunz A 1988 Impact of improved dental services on the frequency of oral complications of cancer therapy for patients with non-head-and-neck malignancies Oral Surg Oral Med Oral Pathol 65 19 22
150. Sonis S Muska A O'Brien J Van Vugt A Langer-Safer P Keith J 1995 Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11 Eur J Cancer B Oral Oncol 31B 261 266
151. Sonis ST Eilers JP Epstein JB et al 1999a Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group Cancer 85 2103 2113
152. Sonis S Edwards L Lucey C 1999b The biological basis for the attenuation of mucositis: the example of interleukin-11 Leukemia 13 831 834
153. Sonis ST Elting LS Keefe D et al 2004a Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients Cancer 100 Suppl. 1995 2025
154. Sonis ST Elting LS Keefe D et al 2004b Perspectives on cancer therapy-induced mucosal injury Cancer 100 Suppl. 1995 2025
155. Spielberger R Stuff P Bensinger W et al 2003 Use of recombinant human keratinocyte growth factor (rHuKGF) can reduce severe oral mucositis in patients with hematologic malignancies using peripheral blood progenitor transplantation after radiation-based conditioning-results of phase 3 trial ASCO Proc., Abstract 3642
156. Spielberger R Stiff P Bensinger W et al 2004 Palifermin for oral mucositis after intensive therapy for hematologic cancers N Engl J Med 351 2590 2598
157. Spijkervet FK Sonis ST 1998 New frontiers in the management of chemotherapy-induced mucositis Curr Opin Oncol 10 Suppl. 1 S23 S27
158. Spijkervet FK van Saene HK Panders AK et al 1989a Effect of chlorhexidine rinsing on the oropharyngeal ecology in patients with head and neck cancer who have irradiation mucositis Oral Surg Oral Med Oral Pathol 67 154 161
159. Spijkervet FK Van Saene HK Panders AK et al 1989b Effect of chlorhexidine rinsing on the oropharyngeal ecology in patients with head and neck cancer who have irradiation mucositis Oral Surg Oral Med Oral Pathol 67 154 161
160. Sprinzl GM Galvan O de Vries A et al 2001 Local application of granulocyte-macrophage colony stimulating factor (GM-CSF) for the treatment of oral mucositis Eur J Cancer 37 2003 2009
161. Suntharalingam M Jaboin J Taylor R et al 2004 The evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (SCCHN) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (RT) Semin Oncol 31 6 Suppl. 18 2 7
162. Sutherland SE Browman GP 2001 Prophylaxis of oral mucositis in irradiated head-and-neck cancer patients: a proposed classification scheme of interventions and meta-analysis of randomized controlled trials Int J Radiat Oncol Biol Phys 49 917 930
163. Symonds RP 1998 Treatment-induced mucositis: an old problem with new remedies Br J Cancer 77 1689 1695
164. Symonds RP McIlroy P Khorrami J et al 1996 The reduction of radiation mucositis by selective decontamination antibiotic pastilles: a placebo-controlled double-blind trial Br J Cancer 74 312 317
165. Tejedor M Valerdi JJ Arias F et al 2000 Hyperfractionated radiotherapy concomitant with cisplatin and granulocyte-macrophage colony stimulating factor (Filgrastim) for laryngeal carcinomas Cytokines Cell Mol Ther 6 35 39
166. Thurmond JM Brown AT Sims RE et al 1991 Oral Candida albicans in bone marrow transplant patients given chlorhexidine rinses: occurrence and susceptibilities to the agent Oral Surg Oral Med Oral Pathol 72 291 295
167. Trotti A Bellm LA Epstein JB et al 2003 Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review Radiother Oncol 66 253 262
168. Tsavaris N Caragiauris P Kosmidis P 1988 Reduction of oral toxicity of 5-fluorouracil by allopurinol mouthwashes Eur J Surg Oncol 14 405 406
169. Verdi CJ Garewal HS Koenig LM Vaughn B Burkhead T 1995 A double-blind, randomized, placebo-controlled, crossover trial of pentoxifylline for the prevention of chemotherapy-induced oral mucositis Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80 36 42
170. Vissink A Jansma J Spijkervet FK et al 2003 Oral sequelae of head and neck radiotherapy Crit Rev Oral Biol Med 14 199 212
171. Vokurka S Bystricka E Koza V et al 2005 The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT-results of a randomized multicentre study Support Care Cancer 13 554 558
172. Wadleigh RG Redman RS Graham ML Krasnow SH Anderson A Cohen MH 1992 Vitamin E in the treatment of chemotherapy-induced mucositis Am J Med 92 481 484
173. Wahlin YB 1989 Effects of chlorhexidine mouthrinse on oral health in patients with acute leukemia Oral Surg Oral Med Oral Pathol 68 279 287
174. Wardley AM Scarffe JH 1996 Role of granulocyte-macrophage colony-stimulating factor in chemotherapy-induced oral mucositis J Clin Oncol 14 1741 1743
175. Wardley AM Jayson GC Swindell R et al 2000 Prospective evaluation of oral mucositis in patients receiving myeloablative conditioning regimens and haemopoietic progenitor rescue Br J Haematol 110 292 299
176. Weisdorf DJ Bostrom B Raether D et al 1989 Oropharyngeal mucositis complicating bone marrow transplantation: prognostic factors and the effect of chlorhexidine mouth rinse Bone Marrow Transplant 4 89 95
177. Wijers OB Levendag PC Harms ER et al 2001 Mucositis reduction by selective elimination of oral flora in irradiated cancers of the head and neck: a placebo-controlled double-blind randomized study Int J Radiat Oncol Biol Phys 50 343 352
178. Wingard JR Merz WG Rinaldi MG Johnson TR Karp JE Saral R 1991 Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole N Engl J Med 325 1274 1277
179. Woo SB Lee SJ Schubert MM 1997 Graft-vs.-host disease Crit Rev Oral Biol Med 8 201 216
180. World Health Organization 1979 Handbook for reporting results of cancer treatment World Health Organization Geneva, Switzerland pp 15 22
181. Worthington 2004 Cochrane Database Syst Rev CD001973
182. Wright J Feld R Knox J 2005 Chemotherapy-induced oral mucositis: new approaches to prevention and management Expert Opin Drug Saf 4 193 200
183. Wymenga AN van der Graaf WT Hofstra LS et al 1999 Phase I study of transforming growth factor-beta3 mouthwashes for prevention of chemotherapy-induced mucositis Clin Cancer Res 5 1363 1368