Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation

Oral Oncology

Volumn 33, Issue 5, 1997, Pages 322-326

  Bondi, E ^a   Baroni, C ^a   Prete, A ^b   Gatti, M ^b   Carrassi, A ^c   Lodi, G ^c,d   Porter, S R ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antimicrobials; Chemotherapy; Mucositis; Oral

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; AMINOCAPROIC ACID; AMPHOTERICIN B; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BUSULFAN; CARBOXYMETHYLCELLULOSE; CHLORHEXIDINE; COLISTIN; DIPHENHYDRAMINE; ETOPOSIDE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MELPHALAN; NYSTATIN; PLATINUM DERIVATIVE; THIOTEPA; TOBRAMYCIN; TRANEXAMIC ACID; VINBLASTINE;

ADOLESCENT; ARTICLE; BLEEDING; BONE MARROW TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CANDIDIASIS; CHILD; CHILDHOOD CANCER; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG INDUCED DISEASE; HUMAN; MOUTH HYGIENE; MOUTH ULCER; MUCOSA INFLAMMATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCORING SYSTEM; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0031406674     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-8375(97)00039-0     Document Type: Article

References (70)

1. Woo, S.-B., Sonis, S. T., Monopoli, M. M. and Sonis, A., A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer, 1993, 72, 1612-1617.
2. Sonis, S. T., Sonis, A. L. and Lieberman, A., Oral complications in patients receiving treatment for malignancies other than of the head and neck. Journal of the American Dental Association, 1978, 97, 468-472.
3. Azul, A. M., Oral complications of the non-surgical management of malignant disease. In Oral Health Care for those with HIV Disease and Other Special Needs, eds S. R. Porter and C. Scully. Science Reviews, Northwood, U.K., 1995, pp. 183-187.
4. Lockhart, P. B. and Sonis, S. T., Relationships of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surgery, Oral Medicine, Oral Pathology, 1979, 48, 21-28.
5. Rosenberg, S. W., Oral complications of cancer chemotherapy: a review of 398 patients. Journal of Oral Medicine, 1986, 41, 93-97.
6. Epstein, J. B., Vickers, L., Spinelli, J. and Reece, D., Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation. Oral Surgery, Oral Medicine, Oral Pathology, 1992, 73, 682-689.
7. McElroy, H. and Guerra, O., Oral/dental management of the head and neck radiation patient. Missouri Medicine, 1985, 81, 15-18.
8. Lockhart, P. B. and Sonis, S. T., Alterations in the oral mucosa caused by chemotherapeutic agents: a histological study. Journal of Dermatologic Surgery and Oncology, 1981, 7, 1019-1025.
9. Main, B. E., Calman, K. C., Ferguson, M. M., et al., The effect of cytotoxic therapy on saliva and oral flora. Oral Surgery, Oral Medicine, Oral Pathology, 1987, 63, 31-36.
10. Barrett, A. P., A long-term prospective clinical study of oral complications during conventional chemotherapy for acute leukemia. Oral Surgery, Oral Medicine, Oral Pathology, 1984, 58, 545-548.
11. Verdi, C. J., Garewal, H. S., Koening, M., Vaughn, B. and Burkhead, T., A double-blind, randomised, placebo-controlled, crossover trial of pentoxifylline for the prevention of chemotherapy-induced oral mucositis. Oral Surgery, Oral Medicine, Oral Pathology, 1995, 80, 36-42.
12. Leahy, I., Germain, J. and Varrechio, C., The Nurse and Radiotherapy, a Manual for Daily Care. CV Mosby, St. Louis, 1979, p. 86.
13. Daeffler, R., Oral hygiene measures for patients with cancer. Cancer Nursing, 1980, 3, 347-356.
14. Yasko, J., Nursing Management of Symptoms Associated with Chemotherapy. Adria Laboratories, Dublin, 1984, pp. 41-42.
15. Dudjak, L. A., Mouth care for mucositis due to radiation therapy. Cancer Nursing, 1980, 10, 131-140.
16. Barker, G., Loftus, L., Cuddy, P. and Barker, B., The effects of sucralfate suspension and diphenhydramine syrup plus kaolinpectin on radiotherapy-induced mucositis. Oral Surgery, Oral Medicine, Oral Pathology, 1991, 71, 228-293.
17. Soloman, M. A., Oral sucralfate suspension for mucositis [letter]. New England Journal of Medicine, 1986, 315, 459-460.
18. Henrikson, R., Franzen, L., Edbom, C. and Littbrand, B., Sucralfrate-prophlaxis of mucosal damage during cancer therapy. Scandinavian Journal of Gastroenterology, 1995, 30 (Suppl. 210), 45-47.
19. Franzen, L., Henriksson, R., Littbrand, B. and Zackrisson, B., Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region - a double-blind placebo-controlled study. Acta Oncologica, 1995, 34, 219-223.
20. Chi, K. H., Chen, C. H., Chan, W. K., et al., Effect of granulocyte-macrophage colony-stimulating factor in oral mucositis in head and neck cancer patients after cisplatin, flurouracil and leucovorin chemotherapy. Journal of Clinical Oncology, 1995, 13, 2620-2628.
21. Cartee, L., Petros, W. P., Rosner, G. L., et al., Evaluation of GM-CSF mouthwash for prevention of chemotherapy-induced mucositis - a randomised, double-blind, dose-ranging study. Cytokine, 1995, 7, 471-477.
22. Blanco, J. A. Applebaum, F. R., Nemunaitis, J. A., et al., Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood, 1991, 78, 1205-1211.
23. Kalhs, P., Lechner, K., Stockschlader, M., et al., Pentoxifylline did not prevent transplant-related toxicity in 31 consecutive allogeneic bone morrow transplant recipients. Blood, 1992, 80, 2683.
24. Attal, M., Huguet, F., Rubie, H., et al., Prevention of regimen related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial. Blood, 1993, 82, 723-726.
25. Clift, R. A., Bianco, J. A., Applebaum, F. R., et al., A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplant. Blood, 1993, 82, 2025-2030.
26. Jebb, S. A., Marcus, R. and Ella, M., A pilot study of oral glutamine supplementation in patients receiving bone marrow transplants. Clinical Nutrition, 1995, 14, 162-165.
27. Sonis, S. T., Costa, J. W. Jr, Evitts, S. M., Lindquist, L. E. and Nicolson, M., Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy. Oral Surgery, Oral Medicine, Oral Pathology, 1992, 74, 749-755.
28. Keith, J. C., Albert, L., Sonis, S. T., Pfeiffer, C. J. and Schaub, R. G., IL-11, a pleiotropic cytokine - exciting new effects of IL-11 on gastrointestinal mucosal biology. Stem Cells, 1994, 12, 79-90.
29. DeGregorio, M. W., Lee, W. M. F. and Ries, C. A., Candida infections in patients with acute leukemia: ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic candidasis. Cancer, 1982, 30, 2780-2784.
30. Bender, J. F., Schimpff, S. C., Young, V. M., et al., A comparative trial of tobramycin vs gentamicin in combination with vancomycin and nystatin for alimentary tract suppression in leukemic patients. European Journal of Cancer, 1979, 15, 35-44.
31. Barrett, A. P., Evaluation of nystatin in prevention and elimination of oropharyngeal candida in immunosuppressed patients. Oral Surgery, Oral Medicine, Oral Pathology, 1984, 58, 148-151.
32. Berkowitz, R. J., Crock, J., Strickland, R., et al., Oral complications associated with bone marrow transplantation in pediatric population. American Journal of Pediatric Hematology/Oncology, 1983, 5, 53-57.
33. Williams, C., Whitehouse, J. M. A., Lister, T. A. and Wrigley, P. F. M., Oral anticandidal prophylaxis in patients undergoing chemotherapy for acute leukemia. Medical and Pediatric Oncology, 1977, 3, 275-280.
34. Meunier-Carpentier, F., Prophylaxis of fungal infections in neutropenic cancer patients. Schweizerische Medizinische Wochenschrift, 1983, 133 (Suppl. 14), 15-19.
35. Caroentieri, V., Haggard, M. E., Lockhart, L. H., Gustavson, L. P., Box, Q. T. and West, E. F., Clinical experience in prevention of candidiasis by nystatin in children with acute lymphocytic leukemia. Journal of Pediatrics, 1978, 92, 593-595.
36. Pizzuto, J., Conte, G., Ambriz, R., Aviles, A. and Morales, M., Nystatin prophylaxis in leukemia and lymphoma. New England Journal of Medicine, 1978, 298, 279-280.
37. Williams, C. J., Nystatin prophylaxis in leukemia and lymphoma. New England Journal of Medicine, 1978, 229, 853.
38. Hann, I. M., Prentice, H. G., Corringham, R., et al., Ketoconazole versus nystatin plus amphotericin B for fungal prophlyaxis in severely immunocompromised patients. Lancet, 1982, 1, 826-829.
39. Lawson, R. D. and Bodey, G. P., Comparison of clotrimazole troche and nystatin vaginal tablet in the treatment of oral pharyngeal candidosis. Current Therapeutic Research, 1980, 27, 774-779.
40. Meunier-Carpentier, F., Cruciani, M. and Klastersky, J., Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients. European Journal of Cancer Clinical Oncology, 1983, 19, 43-48.
41. Brinkner, H., Treatment of oral candidiasis in debilitated paients with miconazole - a new potent antifungal drug. Scandinavian Journal of Infectious Diseases, 1976, 8, 117-120.
42. Aviles, A., Clotrimazole treatment for prevention of oral candidiasis in patients with acute leukemia undergoing chemotherapy. American Journal of Medicine, 1987, 82, 867-868.
43. Malcom, L. G., Volgler, W. R. and Winton, E. F., A phase III trial comparing ketoconazole (R41400) and invasive fungal infections in the neutropenic immunosuppressed patient [Abstract]. American Society of Clinical Oncology, 1982, 1, 67.
44. Allison, R. P., Vongtama, V., Vaughan, J. and Shin, K. H., Symptomatic acute mucositis can be minimized or prophylaxed by the combination of sucralfate and fluconazole. Cancer Investigation, 1995, 13, 16-22.
45. Langslet, A., Olsen, I., Lie, S. I. and Lokken, P., Chlorhexidine treatment of oral candidosis in seriously diseased children. Acta Pediatrica Scandinavica, 1974, 63, 809-811.
46. Spiers, A. S. D., Dias, S. F. and Lopez, J. A., Infection prevention in patients with cancer: microbiological evaluation of portable laminar air flow isolation, topical chlorhexidine, and oral non-absorbable antibiotics. Journal of Hygiene (Cambridge), 1980, 84, 475.
47. McGaw, W. T. and Belch, A., Oral complications of acute leukemia: prophylactic impact of a chlorhexidine, mouth rinse regimen. Oral Surgery, Oral Medicine, Oral Pathology, 1985, 60, 275-280.
48. Ash, R. C., Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies. Oral Surgery, Oral Medicine, Oral Pathology, 1987, 63, 683-687.
49. Ferretti, G. A., Largent, B. M., Ash, R. C., Kaplan, A., Brown, A. T. and Lillich, A. T., Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants. Journal of the American Dental Association, 1987, 114, 461-467.
50. Ferretti, G. A., Ash, R. C., Brown, A. T., Control of oral mucositis and candidiasis in marrow transplantation: a prospective, double-blind trial of chlorhexidine digluconate oral rinse. Bone Marrow Transplantation, 1988, 3, 483-493.
51. Shepherd, J. P., The management of the oral complications of leukemia. Oral Surgery, Oral Medicine, Oral Pathology, 1978, 45, 543-548.
52. Weisdorf, D. J., Bostrom, B., Raether, D., et al., Oropharyngeal mucositis complicating bone marrow transplantation: prognostic factors and the effect of chlorhexidine mouth rinse. Bone Marrow Transplantation, 1989, 4, 89-95.
53. Kostiala, I., Kostiala, A. A. L., Klonen, E., Valtonen, V. V. and Vuopio, P., Comparison of clotrimazole and chlorhexidine in the topical treatment of acute fungal stomatitis in patients with hematological malignancies. Current Therapeutic Research, 1982, 31, 752-763.
54. Wahlin, Y. B., Effects of chlorhexidine mouthrinse on oral health in patients with acute leukaemia. Oral Surgery, Oral Medicine, Oral Pathology, 1989, 68, 279-287.
55. Spijkervet, F. K. L., Van Saene, H. K. F., Panders, A. K., et al., Effect of chlorhexidine rinsing on the oropharyngeal ecology in patients with head and neck cancer who have irradiation mucositis. Oral Surgery, Oral Medicine, Oral Pathology, 1989, 67, 154-161.
56. Foote, R. L., Loprinzi, C. L., Frank, A. R., et al., Randomised trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis. Journal of Clinical Oncology, 1994, 12, 2630-2633.
57. Epstein, J. B., Stevenson-Moore, P., Jackson, S., Mohamed, J. H. and Spinelli, J. J., Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse. International Journal of Radiation Oncology Biology Physics, 1989, 16, 1571-1575.
58. Samaranayake, L. P., Robertson, A. G., MacFarlane, T. W., et al., The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clinical Radiology, 1988, 39, 291-294.
59. Berger, A., Henderson, M., Nadoolman, W., et al., Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy radiation therapy. Journal of Pain and Symptom Management, 1995, 10, 243-248.
60. Dumontet, C., Sonnet, A. and Bastion, Y., Prevention of high dose L-PAM induced mucositis by cryotherapy. Bone Marrow Transplantation, 1994, 3, 492-494.
61. Metoni, G., Capria, S., Proza, A., Trisolini, S. M. and Mandelli, F., Ice pops to prevent melphalan-induced stomatitis. Lancet, 1996, 347, 1691-1692.
62. Spijkervet, F. K., Saene, H. K. van, Saene, J. J. van, Panders, A. K., Vermey, A. and Mehta, D. M., Mucositis prevention by selective elimination of oral flora in irradiation head and neck cancer patients. Journal of Oral Pathology and Medicine, 1990, 19, 486-489.
63. Dreizen, S., Keating, M. J., McCredie, K. B. and Bodey, G. P., Oral infections associated with chemotherapy. Postgraduate Medicine, 1982, 71, 133-146.
64. Meyers, J. D. and Atkinson, K., Infection in bone marrow transplantation. Journal of Clinical Hematology, 1983, 12, 791-811.
65. Galili, D., Tagger, N., Sela, M. N. and Garfunkel, A. A., Surveillance of oral cultures for Enterobacteriaceae during bone marrow transplantation. Oral Oncology, European Journal of Cancer, 1995, 31B, 58-62.
66. Eilers, J., Berger, A. M. and Petersen, M. C., Development, testing and application of the oral assessment guide. Oncology Nursing Forum, 1988, 15, 325-330.
67. Borowski, B., Benhamou, E., Pico, J. L., Laplanche, A., Margainaud, J. P. and Hayat, M., Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial comparing two protocols of dental care. Oral Oncology, European Journal of Cancer, 1994, 30, 93-97.
68. Steinberg, D. A., Hurst, M. A., Fujii, C. A., Broad spectrum antimicrobial activity of protegrin peptides presented at the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, U.S.A., 15-18 September 1996.
69. Singh, N., Scully, C. and Joyston-Bechal, S., Oral complications of cancer therapies: prevention and management. Clinical Oncology, 1996, 8, 15-24.
70. Scully, C. and Epstein, J. B., Oral health care for the cancer patient. Oral Oncology, European Journal of Cancer, 1996, 32B, 281-292.