Neuronal death is an active, caspase-dependent process after moderate but not severe DNA damage

Journal of Neurochemistry

Volumn 76, Issue 2, 2001, Pages 520-531

  Gobbel, Glenn T ^a   Chan, Pak H ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; DNA damage; Ionizing radiation; Lipid peroxidation; Neuron

Indexed keywords

CASPASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; DNA DAMAGE; IONIZING RADIATION; LIPID PEROXIDATION; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASES; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOME BREAKAGE; DNA; DNA DAMAGE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLUORESCENT DYES; LIPID PEROXIDATION; NEURONS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; X-RAYS;

EID: 0035135477     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00070.x     Document Type: Article

References (47)

1. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
2. Apoptosis and necrosis: Two distinct event induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
3. The pecking order of free radicals and antioxidants: Lipid peroxidation, alpha-tocopherol, and ascorbate
4. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo
5. Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema
6. Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase
7. DNA damage and DNA damage-inducible protein Gadd45 following ischemia in the P7 neonatal rat
8. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
9. Transient global ischemia triggers expression of the DNA damage-inducible gene GADD45 in the rat brain
10. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
11. Host biochemical defense mechanisms against prooxidants
12. Nitric oxide neurotoxicity
13. Oxidative damage to DNA in mammalian chromatin
14. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis?
15. Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
16. Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK (+) 801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex
17. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
18. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity
19. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
20. Response of cerebral endothelial cells to hypoxia: Modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists
21. Response of postmitotic neurons to x-irradiation: Implications for the role of DNA damage in neuronal apoptosis
22. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
23. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
24. Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia
25. Immunohistochemical markers for neurons and astrocytes show pan-necrosis following infusion of high-dose NMDA into rat cortex
26. The acute neurotoxic effect of beta-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F
27. Up-regulation of base excision repair activity for 8-hydroxy-2′-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion
28. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
29. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons
30. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
31. Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man
32. Phospholipid membrane stabilization by dimethylsulfoxide and other inducers of Friend leukemic cell differentiation
33. BCL-2 gene family in the nervous system
34. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the 'comet' assay
35. Kainate-induced cell death in hippocampal neurons
36. Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?
37. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione
38. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
39. Mitochondrial toxins in models of neurodegenerative disease. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions
40. Quantitation of the hydroxyl radical by reaction with dimethyl sulfoxide
41. Synthesis of specific proteins in trophic factor-deprived neurons undergoing apoptosis
42. The role of free radicals and p53 in neuron apoptosis in vivo
43. Cell death: The significance of apoptosis
44. Bax involvement in p53-mediated neuronal cell death
45. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity