Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells

Respiration

Volumn 73, Issue 3, 2006, Pages 347-359

  Yasuo, Masanori ^a   Fujimoto, Keisaku ^a   Tanabe, Tsuyoshi ^a   Yaegashi, Hironobu ^a   Tsushima, Kenji ^a   Takasuna, Keiichirou ^a   Koike, Takeshi ^a   Yamaya, Mutsuo ^b   Nikaido, Toshio ^c  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Bronchial epithelial cells; Goblet cell hyperplasia; hCLCA1; Interleukin 13; MUC5AC

Indexed keywords

CALCIUM ACTIVATED CHLORIDE CHANNEL 1; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA1; MESSENGER RNA; MUCIN 5AC; NIFLUMIC ACID; PROTEIN; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CELL COUNT; CELL DENSITY; CELL DIFFERENTIATION; CELL HYPERPLASIA; CELL ISOLATION; CONTROLLED STUDY; GOBLET CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SECRETORY GRANULE; TH2 CELL;

ADULT; AGED; BLOTTING, WESTERN; BRONCHI; CELLS, CULTURED; CHLORIDE CHANNELS; GENE EXPRESSION; GOBLET CELLS; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-13; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MUCINS; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33646581334     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091391     Document Type: Article

References (40)

1. Widdicombe JH, Widdicombe JG: Regulation of human airway surface liquid. Respir Physiol 1995;99:3-12.
2. Rogers DF: The airway goblet cell. Int J Biochem Cell Biol 2003;35:1-6.
3. Aikawa T, Shimura S, Sasaki H, Ebina M, Takishima T: Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 1992;101:916-921.
4. Kaneko Y, Yanagihara K, Miyazaki Y, Hirakata Y, Mukae H, Tomono K, Okada Y, Kadota J, Kohno S: Overproduction of MUC5AC core protein in patients with diffuse panbronchiolitis. Respiration 2003;70:475-478.
5. de Vries JE: The role of IL-13 and its receptor in allergy and inflammatory responses. J Allergy Clin Immunol 1998;102:165-169.
6. Minty A, Asselin S, Bensussan A, Shire D, Vita N, Vyakarnam A, Wijdenes J, Ferrara P, Caput D: The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes. Eur Cytokine Netw 1997;8:203-213.
7. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD: Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261.
8. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma Bing, Riese RJ Jr, Chapman HA, Shapiro SD, Elias JA: Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest 2000;106:1081-1093.
9. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-788.
10. Kondo M, Tamaoki J, Takeyama K, Nakata J, Nagai A: Interleukin-13 induces goblet cell differentiation in primary cell culture from guinea pig tracheal epithelium. Am J Respir Cell Mol Biol 2002;27:536-541.
11. Atherton HC, Jones G, Danahay H: IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003;285:L730-L739.
12. Knowles MR, Clarke LL, Boucher RC: Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. N Engl J Med 1991;325:533-538.
13. Groneberg DA, Eynott PR, Oates T, Lim S, Wu R, Carlstedt I, Nicholson AG, Chung KF: The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice. Am J Respir Cell Mol Biol 1998;19:853-866.
14. - channel proteins. Genomics 1998;54:200-214.
15. Nakanishi A, Morita S, Iwashita H, Sagiya Y, Ashida Y, Shirafuji H, Fujisawa Y, Nishimura O, Fujino M: Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001;98:5175-5180.
16. - channel 1 (CaCC1) gene in the asthmatic airway. Am Respir Crit Care Med 2002;165:1132-1136.
17. Fujimoto K, Morita S, Iwashita H, Kimura H, Gono H, Nakanishi A, Kubo K: Gene expression of calcium-dependent chloride channel (CLCA) family in the sputum cells from COPD (abstract). Am J Respir Crit Care Med 2002;165:A599.
18. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002;8:885-889.
19. Yamaya M, Finkbeiner WE, Widdicombe JH: Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol 1992;262:L713-L724.
20. Gray T, Guzman K, Davis CW, Abdullah LH, Nettesheim P: Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 1996;14:104-112.
21. Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA, Ueki IF, Grattan KM, Nadel JA: Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 1999;96:3081-3086.
22. Rose MC, Piazza FM, Chen YA, Alimam MZ, Bautista MV, Letwin N, Rajput B: Model systems for investigating mucin gene expression in airway diseases. J Aerosol Med 2000;13:245-261.
23. Atherton H, Mesher J, Poll CT, Danahay H: Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium. Naunyn Schmiedebergs Arch Pharmacol 2003;367:214-217.
24. Yoon JH, Gray T, Gutzman K, Koo JS, Nettesheim P: Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix. Am J Respir Cell Mol Biol 1997;16:724-731.
25. Chuanzhong Y, Ming G, Fanglin Z, Haijiao C, Zhen L, Shiping C, YongKang Z: Real-time quantitative reverse transcription-PCR assay for renal cell carcinoma-associated antigen G250. Clin Chim Acta 2002;318:33-40.
26. Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR: Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol 2004;164:577-588.
27. Sandoz D, Nicolas G, Laine MC: Two mucous cell types revisited after quick-freezing and cryosubstitution. Biol Cell 1985;54:79-88.
28. Kametani K: Detection of aluminium by energy dispersive X-ray microanalysis at high accelerating voltages with semi-thin sections of biological sample. J Electron Microsc (Tokyo) 2002;51:265-274.
29. Ishibashi Y, Inouye Y, Okano T, Taniguchi A: Regulation of sialyl-Lewis x epitope expression by TNF-α and EGF in an airway carcinoma cell line. Glycoconj J 2005;22:53-62.
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
31. Zhou Y, Shapiro M, Dong Q, Louahead J, Weiss C, Wan SH, Chen Q, Dragwa C, Savio, Huang M, Fuller C, Tomer Y, Nicolaides NC, McLane M, Levitt RC: A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. Novartis Found Symp 2002;248:150-165.
32. Davey EJ, Greicius G, Thyberg J, Severinson E: STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells. Int Immunol 2000;12:995-1003.
33. Robichaud A, Tuck SA, Kargman S, Tam J, Wong E, Abramovitz M, Mortimer J, Burston HE, Masson P, Hirota J, Slipetz D, Kennedy B, O'Neill G, Xanthoudakis S: Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol 2005;33:303-314.
34. Fahy JV: Goblet cell and mucin gene abnormalities in asthma. Chest 2002;122(suppl): 320S-326S.
35. Kibe A, Inoue H, Fukuyama S, Machida K, Matsumoto K, Koto H, Ikegami T, Aizawa H, Hara N: Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med 2003;167:50-56.
36. Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA: IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 1999;162:6233-6237.
37. Leverkoehne I, Gruber AD: The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 2002;50:829-838.
38. Shim JJ, Dabbagh K, Ueki IF, Dao-Pick T, Burgel PR, Takeyama K, Tam DC, Nadel JA: IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 2001;280:L134-L140.
39. Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA: Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 2000;9:549-559.
40. 2 chain in bronchial epithelial cells. Cytokine 2003;24:293-303.