Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4353-4360

  Mavromoustakos, T ^a   Moutevelis Minakakis, P ^b   Kokotos, C G ^b   Kontogianni, P ^b   Politi, A ^a   Zoumpoulakis, P ^a   Findlay, J ^c   Cox, A ^c   Balmforth, A ^c   Zoga, A ^d   Iliodromitis, E ^d  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Angiotensin II; AT1 antagonists; FlexX; MM1; MMK2; MMK3

Indexed keywords

1 (3 METHOXYBENZYL) 5 (1H BENZIMIDAZOL 1 YLMETHYL) 2 PYRROLIDINONE; 1 (3 METHOXYBENZYL) 5 (1H IMIDAZOL 1 YLMETHYL) 2 PYRROLIDINONE; 1 (3 METHOXYBENZYL) 5 CARBOMETHOXY 2 PYRROLIDINONE; 1 (3 METHOXYBENZYL) 5 HYDROXYMETHYL 2 PYRROLIDINONE; 1 (3 METHOXYBENZYL) 5 HYDROXYMETHYL 2 PYRROLIDINONE TOSYL ESTER; 1 BENZYL 5 (1H IMIDAZOL 1 YLMETHYL) 2 PYRROLIDINONE; 1 BENZYL 5 CARBOMETHOXY 2 PYRROLIDINONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; LOSARTAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE REGULATION; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; HYPERTENSION; NONHUMAN; RABBIT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CELLS, CULTURED; HUMANS; IMIDAZOLES; MALE; PROTEIN CONFORMATION; PYRROLIDINES; RABBITS; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 33646565357     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.044     Document Type: Article

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