The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 1, 2000, Pages 1-10

  Matsoukas, John M ^a   Polevaya, Ludmila ^b   Ancans, Juris ^b   Mavromoustakos, Thomas ^c   Kolocouris, Antonios ^c   Roumelioti, Panagiota ^a   Vlahakos, Demetrios V ^d   Yamdagni, Raghav ^e   Wu, Qiao ^e   Moore, Graham J ^e,f  

^a UNIVERSITY OF PATRAS   (Greece)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c INSTITUTE OF BIOLOGY   (Greece)

^d ONASSIS CARDIAC SURGERY CENTER   (Greece)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Angiotensin II; Charge relay system; Conformation; Cyclic analogues; Ring cluster

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN II DERIVATIVE; ANGIOTENSIN II[1 SARCOSINE 3 LYSINE 5 GLUTAMATE]; UNCLASSIFIED DRUG;

AGONIST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; MALE; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRESSOR RESPONSE; RABBIT; RAT; UTERUS CONTRACTION;

ANGIOTENSIN II; ANIMALS; FEMALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RATS; RECEPTORS, ANGIOTENSIN; UTERUS;

ANIMALIA; MAIA; ORYCTOLAGUS CUNICULUS;

EID: 18144433890     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00266-7     Document Type: Article

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