Seeking the active site of the AT1 receptor for computational docking studies

Drug Design Reviews Online

Volumn 2, Issue 7, 2005, Pages 537-545

  Zoumpoulakis, P ^a   Mavromoustakos, T ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Angiotensin II; AT1 receptor; AT1 antagonists; Losartan; SiteID; SYBYL (DOCK)

Indexed keywords

AMINO ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CANDESARTAN HEXETIL; EPROSARTAN; HISTIDINE; IRBESARTAN; LIPID; LOSARTAN; LYSINE; OLMESARTAN; RHODOPSIN; TELMISARTAN; VALINE; VALSARTAN;

AMINO ACID ANALYSIS; BINDING SITE; CALCULATION; COMPUTER MODEL; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENERGY; HYPERTENSION; LIPID BILAYER; MATHEMATICAL ANALYSIS; MOLECULAR MECHANICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PREDICTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; THEORETICAL STUDY; X RAY;

EID: 27744537768     PISSN: 15672697     EISSN: 15672697     Source Type: Journal    
DOI: 10.2174/156726905774641217     Document Type: Review

References (54)

1. de Gasparo, M.; Catt, K.J.; Inagami, T.; Wright, J.W.; Unger, T. International Union of Pharmacology:XXIII: the angiotensin II receptors. Pharmacol. Rev. 2000, 52, 415.
2. Wagenaar, L.J.; Voors, A.A.; Buikema, H.; van Gilst, W.H. Can. J. Cardiol. 2002,18, 1331.
3. Kusserow, H.; Unger, T. Pharmacol. Toxicol. 2004, 94, 5.
4. Nap, A.; Balt, J.C.; Mathgy, M.J.; van Zwieten, P.A. AutonAutacoid Pharmacol. 2004, 23, 285.
5. Sander, C.; and Schneider, R. Proteins 1991, 9(1), 56.
6. Baldwin, J. EMBO J. 1993, 12, 1693.
7. Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Le Trong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.; and Miyano, M. Science 2000; 4(289), 739.
8. Wess, J. FASEB J. 1997, 11, 346.
9. Schwartz, T.W. and Rosenkilde, M.M. Trends Pharmacol. Sci. 1996, 17, 213.
10. Cirillo, R.; Renzetti, A.R.; Cucchi, P.; Guelfi, M.; Salimbeni, A.; Caliari, S.; Castellucci, A.; Evangelista, S.; Subissi, A.; Giachetti, A. Br. J. Pharmacol. 1995, 114, 1117.
11. Robertson, M.J.; Barnes, J.C.; Drew, G.M.; Clark, K.L.; Marshall, F.H.; Michel, A.; Middlemiss, D.; Ross, B.C.; Scopes, D.; Dowle, M.D.; Br. J. Pharmacol. 1992, 107, 1173.
12. Timmermans, P.B.M.W.M.; Wong, P.C.; Chiu, A.T.; Herblin, W.F. Trends. Pharmacol. Sci. 1991, 12, 55.
13. De Chaffoy de Courcelles, D.; Leysen, J.E.; Roevens, P.; Van Belle, H. Drug Dev. Res. 1986, 8, 173.
14. Robertson, M.J.; Dougall, I.G.; Harper, D.; Mckechnie, K.C.W.; Leff, P. Trends Pharmacol. Sci. 1994, 15, 364.
15. Wienen, W.; Hauel, N.; Van Meel, J.C.A.; Narr, B.; Ries, U.; Entzeroth, M. Br. J. Pharmacol. 1993, 110, 245.
16. Dickinson, K.E.; Cohen, R.B.; Skwish, S.; Delaney, C.L.; Serafino, R.P.; Poss, M.A.; Gu, Z.; Ryono, D.E.; Moreland, S.; Powell, J.R. Br. J. Pharmacol. 1994, 113, 179.
17. Olins, G.M.; Chen, S.T.; McMahon, E.G.; Palomo, M.A.; Reitz, D.B. Mol. Pharmacol. 1994, 47, 115.
18. Ojima, M.; Inada, Y.; Shibouta, Y.; Wada, T.; Sanada, T.; Kubo, K.; Nishikawa, K. Eur. J. Pharmacol. 1997, 319, 137.
19. Panek, R.L.; Lu, G.H.; Overhisser, R.W.; Major, T.C.; Hodges, J.C.; Taylor, D.G. J. Pharmacol. Exp. Ther. 1995, 273, 753.
20. Liu, Y.J.; Shankley, N.P.; Welsh, N.J.; Black, J.W. Br. J. Pharmacol. 1992, 106, 233.
21. Nirula, V.; Zheng, W.; Krishnamurthi, K.; Sandberg, K. FEBS Lett. 1996, 394, 361.
22. Schambye, H.T.; Hjorth, S.A.; Weinstock, J.; Schwartzn, W. Mol. Pharmacol. 1995, 47, 425.
23. Nirula, V.; Zheng, W.; Sothinathan, R.; Sandberg, K. Br. J. Pharmacol. 1996, 119, 1505.
24. Ji, H.; Zheng, W.; Zhang, Y.; Catt, K.J.; Sandberg, K. Proc. Natl. Acad. Sci. 1995, 92, 9240.
25. Hunyady, L.; Ji, H.; Jagadeesh, G.; Zhang, M.; Gaborik, Z.; Mihalik, B.; Catt, K.J. Mol. Pharmacol. 1998, 54, 427.
26. Fierens, F.L.P.; Vanderbeyden, P.M.L.; Gaborik, Z.; LeMinb, T.; DeBacker, J.P.; Hunyady, L.; Ijzerman, A.; Vauquelin, G. JRAAS 2001, 1, 283.
27. Yamano, Y.; Ohyama, K.; Kikyo, M.; Sano, T.; Nakagomi, Y.; Inoue, Y.; Nakamura, N.; Morishima, I.; Guo, D.F.; Hamakubo, T.; Inagami, T. J. Biol. Chem. 1995, 270, 14024.
28. Noda, K.; Saad, Y.; Kinoshita, A.; Boyle, T.P.; Graham, R.M.; Husain, A.; Karnik, S.S. J. Biol. Chem. 1995, 270, 2284.
29. Hunyady, L.; Balla, T.; Catt, K. Trends Pharmacol. Sci. 1996, 17, 135.
30. Wang, C.; Jayadev, S.; Escobedo, J.A. J. Biol. Chem. 1995, 270, 16677.
31. Hjorth, S.A.; Schambye, H.T.; Greenlee, W.J.; Schwartz, T.W. J. Biol. Chem. 1994, 269, 30953.
32. Monnot, C.; Bihoreau, C.; Conchon, S.; Curnow, K.M.; Corvol, P.; Clauser, E. J. Biol. Chem. 1996, 271, 1507.
33. Miura, S.I.; Feng, Y.H.; Husain, A.; Karnik, S.S. J. Biol. Chem. 1999, 274, 7103.
34. Nirula, V.; Zheng, W.; Sothinathan, R.; Sandberg, K. Br. J. Pharmac. 1996, 119, 1505.
35. Hunyady, L.; Balla, T., Catt, K.J. TiPS 1996, 17, 135.
36. Prendergast, K.; Adams, K.; Greenlee, W.J.; Nachbar, R.B.; Patchett, A.A.; Underwood, D.J. J. Comp. Aid. Mol. Des. 1994, 8, 491.
37. Balmforth, A.J.; Lee, A.L.; Warburton, P.; Donnelly, D.; Ball, S.G. J. Biol. Chem. 1997, 272, 4245.
38. Mavromoustakos, T.; Zoumpoulakis, P.; Kyrikou, I.; Zoga, A.; Siapi, E.; Zervou, M.; Daliani, I.; Dimitriou, D.; Pitsas, A.; Kamoutsis, C.; Laggner, P. Curr. Top. Med. Chem. 2003, 4, 385.
39. Zoumpoulakis, P.; Daliani, I.; Zervou, M.; Kyrikou, I.; Siapi, E.; Lamprinidis, G.; Mikros, E.; Mavromoustakos, T. Chem. Physics Lipids 2003, 125, 13.
40. Theodoropoulou, E.; Marsh, D. Biochim. Biophys. Acta 1999, 1461, 135.
41. Mavromoustakos, T.; Daliani, I.; Matsoukas, J. In Drug Discovery and Design: Medical Aspects, IOS Press-Ohmsha, 1999; Vol. 22, pp.13-24.
42. Gether, U. Endocr. Rev. 2000, 21, 90.
43. Peleg, G.; Ghanouni, P.; Kobilka, B.K.; Zare, R.N. Proc. Natl. Acad. Sci. USA 2001, 98, 8469.
44. Noda, K.; Feng, Y.H.; Liu, X.P.; Saad, Y.; Hussain, A.; Karnik, S.S. Biochemistry 1996, 35, 1635.
45. Le, M.T.; Vanderheyden, P.M.L.; Szaszak, M.; Hunyady, L.; Vauquelin, G. J. Biol. Chem. 2002, 277, 23107.
46. Groblewski, T.; Maigret, B.; Larguier, R.; Lombard, C.; Bonnafous, J.C.; Marie, J. J. Biol. Chem. 1997, 272, 1822.
47. Le, M.T.; Vanderheyden, P.M.L.; Szaszak, M.; Hunyady, L.; Kersemans, V.; Vauquelin, G. Biochem. Pharmacol. 2003, 65, 1329.
48. Lew, M.J.; Ziogas, J.; Christopoulos, A. Trends Pharmacol. Sci. 2000, 21, 376.
49. Lew, M.J.; Christopoulos, A.; Ziogas, J. Trends Pharmacol. Sci. 2001, 22, 65.
50. Lew, M.J.; Christopoulos, A.; Ziogas, J. Trends Pharmacol. Sci. 2001, 22, 555.
51. Lew, M.J.; Ziogas, J. Bioch. Pharmacol. 2004, 67, 397.
52. Miura, S.; Saku, K.; Karnik, S.S. Hypertens Res. 2003, 26, 937.
53. Mavromoustakos, T.; Kolocouris, A.; Zervou, M.; Roumelioti, P.; Matsoukas, J.; Weisemann, R. J. Med. Chem. 1999, 42, 1714.
54. Cappelli, A.; Mohr, G.P.; Gallelli, A.; Rizzo, M.; Anzini, M.; Vomero, S.; Mennuni, L.; Ferrari, F.; Makovec, F.; Menziani, M.C.; De Benedetti, P.G.; Giorgi, G. J. Med. Chem. 2004, 47, 2574.