메뉴 건너뛰기




Volumn 2, Issue 2, 2006, Pages 215-228

Clopidogrel resistance: Fact and fiction

Author keywords

Antiplatelet therapy; Clopidogrel resistance; Post treatment platelet reactivity

Indexed keywords

3 [7 [2 (3,4 DIFLUOROPHENYL)CYCLOPROPYLAMINO] 5 PROPYLTHIO 1,2,3 TRIAZOLO[4,5 D]PYRIMIDIN 3 YL] 5 HYDROXYMETHOXY 1,2 CYCLOPENTANEDIOL; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ATORVASTATIN; CANGRELOR; CLOPIDOGREL; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; FIBRIN; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; PRASUGREL; PURINE P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SIMVASTATIN; THROMBIN; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 33646559855     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/14796678.2.2.215     Document Type: Review
Times cited : (20)

References (113)
  • 1
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK: Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N. Engl. J. Med. 345(7), 494-502 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 2
    • 0037145863 scopus 로고    scopus 로고
    • CREDO Investigators: Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT 3rd et al.: CREDO Investigators: clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288(19), 2411-2420 (2002).
    • (2002) JAMA , vol.288 , Issue.19 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 3
    • 0036379817 scopus 로고    scopus 로고
    • Individual variations of platelet inhibition after loading doses of clopidogrel
    • Jaremo P, Lindahl TL, Fransson SG, Richter A: Individual variations of platelet inhibition after loading doses of clopidogrel. J. Intern. Med. 252(3), 233-238 (2002).
    • (2002) J. Intern. Med. , vol.252 , Issue.3 , pp. 233-238
    • Jaremo, P.1    Lindahl, T.L.2    Fransson, S.G.3    Richter, A.4
  • 4
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM: Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 107(23), 2908-2913 (2003).
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 6
    • 0037406216 scopus 로고    scopus 로고
    • Durability of platelet inhibition by clopidogrel
    • Gurbel PA, Bliden KP: Durability of platelet inhibition by clopidogrel. Am. J. Cardiol. 91(9), 1123-1125 (2003).
    • (2003) Am. J. Cardiol. , vol.91 , Issue.9 , pp. 1123-1125
    • Gurbel, P.A.1    Bliden, K.P.2
  • 7
    • 9644281092 scopus 로고    scopus 로고
    • Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting
    • Angiolillo, DJ, Fernandez-Ortiz A, Bernardo E et al.: Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting. Thromb. Res. 115(1-2), 101-108 (2005).
    • (2005) Thromb. Res. , vol.115 , Issue.1-2 , pp. 101-108
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 8
    • 0022599662 scopus 로고
    • Endothelium-dependent inhibition of platelet aggregation
    • Azuma H, Ishikawa M, Sekizaki S: Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmacol. 88(2), 411-415 (1986).
    • (1986) Br. J. Pharmacol. , vol.88 , Issue.2 , pp. 411-415
    • Azuma, H.1    Ishikawa, M.2    Sekizaki, S.3
  • 9
    • 0023446425 scopus 로고
    • The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide
    • Radomski MW, Palmer RMJ, Moncada S: The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol. 92, 639-646 (1987).
    • (1987) Br. J. Pharmacol. , vol.92 , pp. 639-646
    • Radomski, M.W.1    Palmer, R.M.J.2    Moncada, S.3
  • 10
    • 0029884604 scopus 로고    scopus 로고
    • Effects of nitric oxide/EDRF on platelet surface glycoproteins
    • Michelson AD, Benoit SE, Furman MI et al.: Effects of nitric oxide/EDRF on platelet surface glycoproteins. Am. J. Physiol. 270(5 Pt 2), H1640-H1648 (1996).
    • (1996) Am. J. Physiol. , vol.270 , Issue.5 PART 2
    • Michelson, A.D.1    Benoit, S.E.2    Furman, M.I.3
  • 11
    • 0032599979 scopus 로고    scopus 로고
    • Shear-dependent functions of the interaction between soluble von Willebrand factor and platelet glycoprotein Ib in mural thrombus formation on a collagen surface
    • Sugimoto M, Tsuji S, Kuwahara M et al.: Shear-dependent functions of the interaction between soluble von Willebrand factor and platelet glycoprotein Ib in mural thrombus formation on a collagen surface. Int. J. Hematol. 69(1), 48-53 (1999).
    • (1999) Int. J. Hematol. , vol.69 , Issue.1 , pp. 48-53
    • Sugimoto, M.1    Tsuji, S.2    Kuwahara, M.3
  • 12
    • 0034042028 scopus 로고    scopus 로고
    • Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor-glycoprotein Ib interaction and inhibited by von Willebrand factor-glycoprotein IIb/IIIa interaction
    • Wu YP, Vink T, Schiphorst M et al.: Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor-glycoprotein Ib interaction and inhibited by von Willebrand factor-glycoprotein IIb/IIIa interaction. Arterioscler. Thromb. Vasc. Biol. 20(6), 1661-1667 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , Issue.6 , pp. 1661-1667
    • Wu, Y.P.1    Vink, T.2    Schiphorst, M.3
  • 13
    • 0027449283 scopus 로고
    • A review of the role of platelet membrane glycoproteins in the platelet-vessel wall interaction
    • Nurden AT, Nurden P: A review of the role of platelet membrane glycoproteins in the platelet-vessel wall interaction. Baillieres Clin. Haematol. 6(3), 653-690 (1993).
    • (1993) Baillieres Clin. Haematol. , vol.6 , Issue.3 , pp. 653-690
    • Nurden, A.T.1    Nurden, P.2
  • 14
    • 0030845292 scopus 로고    scopus 로고
    • Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin αIIbβ3) in von Willebrand factor-induced signal transduction
    • Yuan Y, Dopheide SM, Ivanidis C, Salem HH, Jackson SP: Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin αIIbβ3) in von Willebrand factor-induced signal transduction. J. Biol. Chem. 272 (35), 21847-21854 (1997).
    • (1997) J. Biol. Chem. , vol.272 , Issue.35 , pp. 21847-21854
    • Yuan, Y.1    Dopheide, S.M.2    Ivanidis, C.3    Salem, H.H.4    Jackson, S.P.5
  • 15
    • 0026661585 scopus 로고
    • Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin αIIbβ3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor
    • Savage B, Shattil SJ, Ruggeri ZM: Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin αIIbβ3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J. Biol. Chem. 267(16), 11300-11306 (1992).
    • (1992) J. Biol. Chem. , vol.267 , Issue.16 , pp. 11300-11306
    • Savage, B.1    Shattil, S.J.2    Ruggeri, Z.M.3
  • 16
    • 0034916133 scopus 로고    scopus 로고
    • Platelet adhesion receptors and (patho)physiological thrombus formation
    • Andrews RK, Shen Y, Gardiner EE, Berndt MC: Platelet adhesion receptors and (patho)physiological thrombus formation. Histol. Histopathol. 16(3), 969-980 (2001).
    • (2001) Histol. Histopathol. , vol.16 , Issue.3 , pp. 969-980
    • Andrews, R.K.1    Shen, Y.2    Gardiner, E.E.3    Berndt, M.C.4
  • 17
    • 2142708565 scopus 로고    scopus 로고
    • Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): Effects of receptor clustering and von Willebrand factor adhesion
    • Arya M, Lopez JA, Romo GM et al.: Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J. Thromb. Haemost. 1(6), 1150-1157 (2003).
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.6 , pp. 1150-1157
    • Arya, M.1    Lopez, J.A.2    Romo, G.M.3
  • 18
    • 7044233073 scopus 로고    scopus 로고
    • Platelet physiology and thrombosis
    • Andrews RK, Berndt MC: Platelet physiology and thrombosis. Thromb. Res. 114(5-6), 447-453 (2004).
    • (2004) Thromb. Res. , vol.114 , Issue.5-6 , pp. 447-453
    • Andrews, R.K.1    Berndt, M.C.2
  • 19
    • 18644372477 scopus 로고    scopus 로고
    • Structure and stereochemistry of the active metabolite of clopidogrel
    • Pereillo JM, Maftouh M, Andrieu A et al.: Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab. Dispos. 30(11), 1288-1295 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.11 , pp. 1288-1295
    • Pereillo, J.M.1    Maftouh, M.2    Andrieu, A.3
  • 20
    • 0033678468 scopus 로고    scopus 로고
    • Identification and biological activity of the active metabolite of clopidogrel
    • Savi P, Pereillo JM, Uzabiaga J et al.: Identification and biological activity of the active metabolite of clopidogrel. Thromb. Haemost. 84, 891-896 (2000).
    • (2000) Thromb. Haemost. , vol.84 , pp. 891-896
    • Savi, P.1    Pereillo, J.M.2    Uzabiaga, J.3
  • 21
    • 0033674495 scopus 로고    scopus 로고
    • Very slow chiral conversion of clopidogrel in rats: A pharmacokinetic and mechanistic investigation
    • Reist M, Vos MR-D, Montseny J-P et al.: Very slow chiral conversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation. Drug Metab. Dispos. 28, 1405-1410 (2000).
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1405-1410
    • Reist, M.1    Vos, M.R.-D.2    Montseny, J.-P.3
  • 22
    • 0028083293 scopus 로고
    • The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A
    • Savi P, Combalbert J, Gaich C et al.: The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A. Thromb. Haemost. 72, 313-317 (1994).
    • (1994) Thromb. Haemost. , vol.72 , pp. 313-317
    • Savi, P.1    Combalbert, J.2    Gaich, C.3
  • 23
    • 0347594033 scopus 로고    scopus 로고
    • In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis
    • Arrebola MM, De la Cruz JP, Villalobos MA, Pinacho A, Guerrero A, Sanchez de la Cuesta F: In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis. J. Cardiovasc. Pharmacol. 43(1), 74-82 (2004).
    • (2004) J. Cardiovasc. Pharmacol. , vol.43 , Issue.1 , pp. 74-82
    • Arrebola, M.M.1    De la Cruz, J.P.2    Villalobos, M.A.3    Pinacho, A.4    Guerrero, A.5    Sanchez de la Cuesta, F.6
  • 24
    • 0031914973 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
    • Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP: Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J. Biol. Chem. 273, 2024-2029 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 2024-2029
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3    Ashby, B.4    Smith, J.B.5    Kunapuli, S.P.6
  • 25
    • 0031916728 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
    • Jin J, Daniel JL, Kunapuli SP: Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J. Biol. Chem. 273, 2030-2034 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 2030-2034
    • Jin, J.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 26
    • 0342723744 scopus 로고    scopus 로고
    • Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptornull mice
    • Leon C, Hechler B. Freund M et al.: Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptornull mice. J. Clin. Invest. 104, 1731-1737 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1731-1737
    • Leon, C.1    Hechler, B.2    Freund, M.3
  • 27
    • 0037452681 scopus 로고    scopus 로고
    • Molecular bases of defective signal transduction in platelet P2Y12 receptor of a patient with congenital bleeding
    • Cattaneo M, Zighetti ML, Lombardi R et al.: Molecular bases of defective signal transduction in platelet P2Y12 receptor of a patient with congenital bleeding. Proc. Natl Acad. Sci. USA 100, 1978-1983 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 1978-1983
    • Cattaneo, M.1    Zighetti, M.L.2    Lombardi, R.3
  • 28
    • 0033828240 scopus 로고    scopus 로고
    • Desensitization of the platelet aggregation response to ADP: Differential down-regulation of the P2Y1 and P2cyc-receptor
    • Baurand A, Eckly A, Bari N et al.: Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc-receptor. Thromb. Haemost. 84, 484-491 (2000).
    • (2000) Thromb. Haemost. , vol.84 , pp. 484-491
    • Baurand, A.1    Eckly, A.2    Bari, N.3
  • 29
    • 18244389451 scopus 로고    scopus 로고
    • P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
    • Hardy AR, Conley PB, Luo J, Benovic JL, Poole AW, Mundell SJ: P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood 105, 3552-3560 (2005).
    • (2005) Blood , vol.105 , pp. 3552-3560
    • Hardy, A.R.1    Conley, P.B.2    Luo, J.3    Benovic, J.L.4    Poole, A.W.5    Mundell, S.J.6
  • 30
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Muller I, Besta F, Schulz C, Massberg S, Schomig A, Gawaz M: Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb. Haemost. 89(5), 783-787 (2003).
    • (2003) Thromb. Haemost. , vol.89 , Issue.5 , pp. 783-787
    • Muller, I.1    Besta, F.2    Schulz, C.3    Massberg, S.4    Schomig, A.5    Gawaz, M.6
  • 31
    • 1242315475 scopus 로고    scopus 로고
    • Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization
    • Mobley JE, Bresee SJ, Wortham DC, Craft RM, Snider CC, Carroll RC: Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization. Am. J. Cardiol. 93(4), 456-458 (2004).
    • (2004) Am. J. Cardiol. , vol.93 , Issue.4 , pp. 456-458
    • Mobley, J.E.1    Bresee, S.J.2    Wortham, D.C.3    Craft, R.M.4    Snider, C.C.5    Carroll, R.C.6
  • 32
    • 11144355993 scopus 로고    scopus 로고
    • Platelet aggregation according to body mass index in patients undergoing coronary stenting: Should clopidogrel loading-dose be weight adjusted?
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al.: Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted? J. Invasive Cardiol. 16(4), 169-174 (2004).
    • (2004) J. Invasive Cardiol. , vol.16 , Issue.4 , pp. 169-174
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 33
    • 7544239072 scopus 로고    scopus 로고
    • High clopidogrel loading dose during coronary stenting: Effects on drug response and interindividual variability
    • Angiolillo, DJ, Fernandez-Ortiz A, Bernardo E et al.: High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability. Eur. Heart J. 25(21), 1903-1910 (2004).
    • (2004) Eur. Heart J. , vol.25 , Issue.21 , pp. 1903-1910
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 34
    • 0038300483 scopus 로고    scopus 로고
    • Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: Do we need more aggressive dosing regimens in unstable angina?
    • Soffer D, Moussa I, Harjai K et al.: Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina? Catheter Cardiovasc. Interv. 59, 21-25 (2003).
    • (2003) Catheter Cardiovasc. Interv. , vol.59 , pp. 21-25
    • Soffer, D.1    Moussa, I.2    Harjai, K.3
  • 35
    • 29244467682 scopus 로고    scopus 로고
    • Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al.: Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention. Am. J. Cardiol. 97(1). 38-43 (2006).
    • (2006) Am. J. Cardiol. , vol.97 , Issue.1 , pp. 38-43
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 36
    • 17144370263 scopus 로고    scopus 로고
    • Resistance to clopidogrel: A review of the evidence
    • Nguyen TA, Diodati JG, Pharand C: Resistance to clopidogrel: a review of the evidence. J. Am. Coll. Cardiol. 45(8), 1157-1164 (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.45 , Issue.8 , pp. 1157-1164
    • Nguyen, T.A.1    Diodati, J.G.2    Pharand, C.3
  • 37
    • 10444235983 scopus 로고    scopus 로고
    • Clopidogrel resistance: A new chapter in a fast-moving story
    • Wiviott SD, Antman EM: Clopidogrel resistance: a new chapter in a fast-moving story. Circulation 109(25), 3064-3067 (2004).
    • (2004) Circulation , vol.109 , Issue.25 , pp. 3064-3067
    • Wiviott, S.D.1    Antman, E.M.2
  • 38
    • 0041936209 scopus 로고    scopus 로고
    • Platelet aggregation
    • Michelson AD (Ed.). Academic Press, San Diego, CA, USA
    • Refaal MA, Laposata M: Platelet aggregation. In: Platelets. Michelson AD (Ed.). Academic Press, San Diego, CA, USA, 291-296 (2004).
    • (2004) Platelets , pp. 291-296
    • Refaal, M.A.1    Laposata, M.2
  • 39
    • 0017902733 scopus 로고
    • Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors
    • Born GV, Dearnley R. Foulks JG, Sharp DE: Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors. J. Physiol. 280, 193-212 (1978).
    • (1978) J. Physiol. , vol.280 , pp. 193-212
    • Born, G.V.1    Dearnley, R.2    Foulks, J.G.3    Sharp, D.E.4
  • 40
    • 0022650427 scopus 로고
    • Critical evaluation of platelet aggregation in whole human blood
    • Riess H, Braun G, Brehm G, Hiller E: Critical evaluation of platelet aggregation in whole human blood. Am. J. Clin. Pathol. 85(1), 50-6 (1986).
    • (1986) Am. J. Clin. Pathol. , vol.85 , Issue.1 , pp. 50-56
    • Riess, H.1    Braun, G.2    Brehm, G.3    Hiller, E.4
  • 41
    • 17144396926 scopus 로고    scopus 로고
    • Platelet function testing in cardiovascular diseases
    • Michelson AD: Platelet function testing in cardiovascular diseases. Circulation 110(19), e489-e493 (2004).
    • (2004) Circulation , vol.110 , Issue.19
    • Michelson, A.D.1
  • 42
    • 0034728866 scopus 로고    scopus 로고
    • Platelets
    • George JN: Platelets. Lancet 355, 1531-1539 (2000).
    • (2000) Lancet , vol.355 , pp. 1531-1539
    • George, J.N.1
  • 43
  • 44
    • 21344442173 scopus 로고    scopus 로고
    • Can platelet aggregometry be standardized?
    • Breddin HK: Can platelet aggregometry be standardized? Platelets 16(3-4), 151-158 (2005).
    • (2005) Platelets , vol.16 , Issue.3-4 , pp. 151-158
    • Breddin, H.K.1
  • 45
    • 21844466265 scopus 로고    scopus 로고
    • Use of native or platelet count adjusted platelet rich plasma for platelet aggregation measurements
    • Mani H, Luxembourg B, Klaffling C, Erbe M, Lindhoff-Last E: Use of native or platelet count adjusted platelet rich plasma for platelet aggregation measurements. J. Clin. Pathol. 58(7), 747-750 (2005).
    • (2005) J. Clin. Pathol. , vol.58 , Issue.7 , pp. 747-750
    • Mani, H.1    Luxembourg, B.2    Klaffling, C.3    Erbe, M.4    Lindhoff-Last, E.5
  • 46
    • 0030610564 scopus 로고    scopus 로고
    • 2+ on GP IIb-IIIa interactions with integrilin: Enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate
    • 2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation 96(5), 1488-1494 (1997).
    • (1997) Circulation , vol.96 , Issue.5 , pp. 1488-1494
    • Phillips, D.R.1    Teng, W.2    Arfsten, A.3
  • 47
    • 23644437489 scopus 로고    scopus 로고
    • Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug
    • Labarthe B, Theroux P, Angioi M, Ghitescu M: Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug. J. Am. Coll. Cardiol. 46(4), 638-645 (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.46 , Issue.4 , pp. 638-645
    • Labarthe, B.1    Theroux, P.2    Angioi, M.3    Ghitescu, M.4
  • 48
    • 30344438281 scopus 로고    scopus 로고
    • Impact of adenosine diphosphate and calcium chelation on platelet aggregation testing in patients receiving clopidogrel therapy
    • Patel P, Gonzales R, Dokainish H, Lakkis N: Impact of adenosine diphosphate and calcium chelation on platelet aggregation testing in patients receiving clopidogrel therapy. J. Am. Coll. Cardiol. 47(2), 464-465 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.47 , Issue.2 , pp. 464-465
    • Patel, P.1    Gonzales, R.2    Dokainish, H.3    Lakkis, N.4
  • 49
    • 0031596559 scopus 로고    scopus 로고
    • PFA-100 system: A new method for assessment of platelet dysfunction
    • Mammen EF, Comp PC, Gosselin R et al.: PFA-100 system: a new method for assessment of platelet dysfunction. Semin. Thromb. Hemost. 24, 195-202 (1998).
    • (1998) Semin. Thromb. Hemost. , vol.24 , pp. 195-202
    • Mammen, E.F.1    Comp, P.C.2    Gosselin, R.3
  • 50
    • 0036344893 scopus 로고    scopus 로고
    • Clinical application of the PFA-100(R)
    • Favaloro EJ: Clinical application of the PFA-100(R). Curr. Opin. Hematol. 9(5), 407-415 (2002).
    • (2002) Curr. Opin. Hematol. , vol.9 , Issue.5 , pp. 407-415
    • Favaloro, E.J.1
  • 51
    • 0032890704 scopus 로고    scopus 로고
    • The effect of antiplatelet drugs, heparin, and preanalytical variables on platelet function detected by the platelet function analyzer (PFA 100)
    • Kottke-Marchant K, Powers JB, Brooks L, Kundu S, Christie DJ: The effect of antiplatelet drugs, heparin, and preanalytical variables on platelet function detected by the platelet function analyzer (PFA 100). Clin. Appl. Thromb. Hemost. 5, 122-130 (1999).
    • (1999) Clin. Appl. Thromb. Hemost. , vol.5 , pp. 122-130
    • Kottke-Marchant, K.1    Powers, J.B.2    Brooks, L.3    Kundu, S.4    Christie, D.J.5
  • 52
    • 0036825956 scopus 로고    scopus 로고
    • PFA-100 and flow cytometry: Can they challenge aggregometry to assess antiplatelet agents, other than GPIIbIIIa blockers, in coronary angioplasty?
    • Hezard N, Metz D, Nazeyrollas P, Droulle C, Potron G, Nguyen P: PFA-100 and flow cytometry: can they challenge aggregometry to assess antiplatelet agents, other than GPIIbIIIa blockers, in coronary angioplasty? Thromb. Res. 108(1), 43-47 (2002).
    • (2002) Thromb. Res. , vol.108 , Issue.1 , pp. 43-47
    • Hezard, N.1    Metz, D.2    Nazeyrollas, P.3    Droulle, C.4    Potron, G.5    Nguyen, P.6
  • 53
    • 1642566141 scopus 로고    scopus 로고
    • Limited usefulness of the PFA-100 for the monitoring of ADP receptor antagonists - In vitro experience
    • Golanski J, Pluta J, Baraniak J, Watala C: Limited usefulness of the PFA-100 for the monitoring of ADP receptor antagonists - in vitro experience. Clin. Chem. Lab. Med. 42(1), 25-29 (2004).
    • (2004) Clin. Chem. Lab. Med. , vol.42 , Issue.1 , pp. 25-29
    • Golanski, J.1    Pluta, J.2    Baraniak, J.3    Watala, C.4
  • 54
    • 0033537494 scopus 로고    scopus 로고
    • Rapid platelet-function assay: An automated and quantitative cartridge-based method
    • Smith JW, Steinhubl SR, Lincoff AM et al.: Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation 99(5), 620-625 (1999).
    • (1999) Circulation , vol.99 , Issue.5 , pp. 620-625
    • Smith, J.W.1    Steinhubl, S.R.2    Lincoff, A.M.3
  • 55
    • 33646572629 scopus 로고    scopus 로고
    • Correlation between platelet response units measured with a point-of-care test and ADP-induced platelet aggregation assessed with conventional aggregometry
    • Stockholm, Sweden, 3-7 September (Abstract P2936)
    • Von Beckerath N, Pogatsa-Murray G, Wieczorek A, Schömig A, Kastrati A: Correlation between platelet response units measured with a point-of-care test and ADP-induced platelet aggregation assessed with conventional aggregometry. Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract P2936).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Von Beckerath, N.1    Pogatsa-Murray, G.2    Wieczorek, A.3    Schömig, A.4    Kastrati, A.5
  • 56
    • 20644450112 scopus 로고    scopus 로고
    • Comparison of modified thrombelastograph and plateletworks whole blood assays to optical aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients
    • Craft RM, Chavez JJ, Snider CC, Muenchen RA, Carroll RC: Comparison of modified thrombelastograph and plateletworks whole blood assays to optical aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients. J. Lab. Clin. Med. 145(6), 309-315 (2005).
    • (2005) J. Lab. Clin. Med. , vol.145 , Issue.6 , pp. 309-315
    • Craft, R.M.1    Chavez, J.J.2    Snider, C.C.3    Muenchen, R.A.4    Carroll, R.C.5
  • 57
    • 0000175721 scopus 로고    scopus 로고
    • What is the appropriate loading dose of clopidogrel prior to stent implantation? Insights from a platelet inhibition study
    • Soffer D, Taviloglu G, New G et al.: What is the appropriate loading dose of clopidogrel prior to stent implantation? Insights from a platelet inhibition study. J. Am. Coll. Cardiol. 35(Suppl. A) (2000).
    • (2000) J. Am. Coll. Cardiol. , Issue.35 SUPPL. A
    • Soffer, D.1    Taviloglu, G.2    New, G.3
  • 58
    • 0001854446 scopus 로고    scopus 로고
    • Rapid platelet function assessment using two concentrations of adenosine diphosphate after clopidogrel loading dose in patients undergoing cardiac catheterization
    • Lau WC, Bates ER, Carville DGM et al.: Rapid platelet function assessment using two concentrations of adenosine diphosphate after clopidogrel loading dose in patients undergoing cardiac catheterization. J. Am. Coll. Cardiol. 35(Suppl. A) (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.35 , Issue.SUPPL. A
    • Lau, W.C.1    Bates, E.R.2    Carville, D.G.M.3
  • 59
    • 27644566409 scopus 로고    scopus 로고
    • Evaluation of the profile of thrombin generation during the process of whole blood clotting as assessed by thromboelastography
    • Rivard GE, Brummel-Ziedins KE, Mann KG, Fan L, Hofer A, Cohen E: Evaluation of the profile of thrombin generation during the process of whole blood clotting as assessed by thromboelastography. J. Thromb. Haemost. 3, 2039-2043 (2005).
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 2039-2043
    • Rivard, G.E.1    Brummel-Ziedins, K.E.2    Mann, K.G.3    Fan, L.4    Hofer, A.5    Cohen, E.6
  • 60
    • 0031258834 scopus 로고    scopus 로고
    • Monitoring platelet glycoprotein IIb/IIIa-fibrin interaction with tissue factor-activated thromboelastography
    • Khurana S, Mattson JC, Westley S, O'Neill WW, Timmis GC, Safian RD: Monitoring platelet glycoprotein IIb/IIIa-fibrin interaction with tissue factor-activated thromboelastography. J. Lab. Clin. Med. 130, 401-411 (1997).
    • (1997) J. Lab. Clin. Med. , vol.130 , pp. 401-411
    • Khurana, S.1    Mattson, J.C.2    Westley, S.3    O'Neill, W.W.4    Timmis, G.C.5    Safian, R.D.6
  • 61
    • 27644481388 scopus 로고    scopus 로고
    • Association of thrombelastography (MA) and thrombotic complications after major non-cardiac surgery
    • McCrath D, Cerboni E, Hirsh A, Frumento RJ, Bennet-Guerrero E: Association of thrombelastography (MA) and thrombotic complications after major non-cardiac surgery, Anesth. Analag. 96, SCA1-SCA141 (2003).
    • (2003) Anesth. Analag. , vol.96
    • McCrath, D.1    Cerboni, E.2    Hirsh, A.3    Frumento, R.J.4    Bennet-Guerrero, E.5
  • 62
    • 27644536235 scopus 로고    scopus 로고
    • Platelet reactivity in patients and recurrent events post-stenting: Results of the PREPARE POST-STENTING Study
    • Gurbel PA, Bliden KP Guyer K et al.: Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. J. Am. Coll. Cardiol. 46(10), 1820-1826 (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.46 , Issue.10 , pp. 1820-1826
    • Gurbel, P.A.1    Bliden, K.P.2    Guyer, K.3
  • 63
    • 0034663206 scopus 로고    scopus 로고
    • Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: Role of platelet activation, fibrinogen, and von Willebrand factor
    • Shenkman B, Savion N, Dardik R, Tamarin I, Varon D: Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen, and von Willebrand factor. Thromb. Res. 99, 353-361 (2000).
    • (2000) Thromb. Res. , vol.99 , pp. 353-361
    • Shenkman, B.1    Savion, N.2    Dardik, R.3    Tamarin, I.4    Varon, D.5
  • 64
    • 21744434186 scopus 로고    scopus 로고
    • A new point-of-care method for monitoring anti-platelet therapy: Application of the cone and plate(let) analyzer
    • Spectre G, Brill A, Gural A et al.: A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer. Platelets 16(5), 293-299 (2005).
    • (2005) Platelets , vol.16 , Issue.5 , pp. 293-299
    • Spectre, G.1    Brill, A.2    Gural, A.3
  • 65
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S, Shenkman B, Guetta V et al.: Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 109(25), 3171-3175 (2004).
    • (2004) Circulation , vol.109 , Issue.25 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3
  • 66
    • 27144451471 scopus 로고    scopus 로고
    • High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease
    • Aleil B, Meyer N, Cazenave JP, Mossard JM, Gachet C: High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease. Thromb. Haemost. 94(4), 886-887 (2005).
    • (2005) Thromb. Haemost. , vol.94 , Issue.4 , pp. 886-887
    • Aleil, B.1    Meyer, N.2    Cazenave, J.P.3    Mossard, J.M.4    Gachet, C.5
  • 67
    • 19644366172 scopus 로고    scopus 로고
    • Monitoring of clopidogrel action: Comparison of methods
    • Geiger J, Teichmann L, Grossmann R et al: Monitoring of clopidogrel action: comparison of methods. Clin. Chem. 51(6), 957-965 (2005).
    • (2005) Clin. Chem. , vol.51 , Issue.6 , pp. 957-965
    • Geiger, J.1    Teichmann, L.2    Grossmann, R.3
  • 68
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C: Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J. Thromb. Haemost. 3(1), 85-92 (2005).
    • (2005) J. Thromb. Haemost. , vol.3 , Issue.1 , pp. 85-92
    • Aleil, B.1    Ravanat, C.2    Cazenave, J.P.3    Rochoux, G.4    Heitz, A.5    Gachet, C.6
  • 69
    • 0038354521 scopus 로고    scopus 로고
    • Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation
    • Barragan P, Bouvier JL, Roquebert PO et al.: Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc. Interv. 59(3), 295-302 (2003).
    • (2003) Catheter Cardiovasc. Interv. , vol.59 , Issue.3 , pp. 295-302
    • Barragan, P.1    Bouvier, J.L.2    Roquebert, P.O.3
  • 70
    • 0032873146 scopus 로고    scopus 로고
    • Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets - Definition and detection of ticlopidine/clopidogrel effects
    • Schwarz UR, Geiger J, Walter U, Eigenthaler M: Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets - definition and detection of ticlopidine/clopidogrel effects. Thromb. Haemost. 82(3), 1145-1152 (1999).
    • (1999) Thromb. Haemost. , vol.82 , Issue.3 , pp. 1145-1152
    • Schwarz, U.R.1    Geiger, J.2    Walter, U.3    Eigenthaler, M.4
  • 71
    • 33645976913 scopus 로고    scopus 로고
    • Impact of peri-interventional platelet inhibition after loading with clopidogrel on 30-days clinical outcome of elective coronary stent placement: The Excelsior Study
    • Stockholm, Sweden, 3-7 September (Abstract 2230)
    • Hochholzer W, Trenk D, Fischer B et al.: Impact of peri-interventional platelet inhibition after loading with clopidogrel on 30-days clinical outcome of elective coronary stent placement: the Excelsior Study Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract 2230).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Hochholzer, W.1    Trenk, D.2    Fischer, B.3
  • 72
    • 33646590698 scopus 로고    scopus 로고
    • High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome
    • (Epub ahead of print)
    • Cuisset T, Frere C, Quilici J et al.: High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J. Thromb. Haemost. (2005) (Epub ahead of print).
    • (2005) J. Thromb. Haemost.
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 74
    • 0032814002 scopus 로고    scopus 로고
    • Clopidogrel loading dose regimens: Kinetic profile of pharmacodynamic responses in healthy subjects
    • Savcic M, Hauert J, Bachmann F: Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic responses in healthy subjects. Semin. Thromb. Haemost. 25, 15-19 (1999).
    • (1999) Semin. Thromb. Haemost. , vol.25 , pp. 15-19
    • Savcic, M.1    Hauert, J.2    Bachmann, F.3
  • 75
    • 0034762075 scopus 로고    scopus 로고
    • Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement
    • Muller I, Seyfarth M, Rudiger S et al.: Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart 85(1), 92-93 (2001).
    • (2001) Heart , vol.85 , Issue.1 , pp. 92-93
    • Muller, I.1    Seyfarth, M.2    Rudiger, S.3
  • 76
    • 4944261759 scopus 로고    scopus 로고
    • Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy
    • Kastrati A, von Beckerath N, Joost A, Pogatsa-Murray G, Gorchakova O, Schomig A: Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy. Circulation 110(14), 1916-1919 (2004).
    • (2004) Circulation , vol.110 , Issue.14 , pp. 1916-1919
    • Kastrati, A.1    von Beckerath, N.2    Joost, A.3    Pogatsa-Murray, G.4    Gorchakova, O.5    Schomig, A.6
  • 77
    • 33646544802 scopus 로고    scopus 로고
    • Assessment of the best loading dose of clopidogrel to blunt platelet activation, inflammation and ongoing necrosis: The Albion study
    • on behalf of all Albion study investigators: Stockholm, Sweden, 3-7 September (Abstract 2956)
    • Montalescot G, on behalf of all Albion study investigators: Assessment of the best loading dose of clopidogrel to blunt platelet activation, inflammation and ongoing necrosis: the Albion study. Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract 2956).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Montalescot, G.1
  • 78
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial
    • von Beckerath N, Taubert D, Pogatsa-Murray G, Schomig E, Kastrati A, Schomig A: Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation 112(19), 2946-2950 (2005).
    • (2005) Circulation , vol.112 , Issue.19 , pp. 2946-2950
    • von Beckerath, N.1    Taubert, D.2    Pogatsa-Murray, G.3    Schomig, E.4    Kastrati, A.5    Schomig, A.6
  • 79
    • 17744376570 scopus 로고    scopus 로고
    • Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: Results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study
    • Patti G, Colonna G, Pasceri V, Pepe LL, Montinaro A, Di Sciascio G: Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study. Circulation 111(16), 2099-2106 (2005).
    • (2005) Circulation , vol.111 , Issue.16 , pp. 2099-2106
    • Patti, G.1    Colonna, G.2    Pasceri, V.3    Pepe, L.L.4    Montinaro, A.5    Di Sciascio, G.6
  • 80
    • 4444353174 scopus 로고    scopus 로고
    • Pharmacokinetics of clopidogrel after administration of a high loading dose
    • Taubert D, Kastrati A, Harlfinger S et al.: Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb. Haemost. 92(2), 311-316 (2004).
    • (2004) Thromb. Haemost. , vol.92 , Issue.2 , pp. 311-316
    • Taubert, D.1    Kastrati, A.2    Harlfinger, S.3
  • 81
    • 16544365185 scopus 로고    scopus 로고
    • Genetics of the variable expression of CYP3A in humans
    • Wojnowski L: Genetics of the variable expression of CYP3A in humans. Ther. Drug Monit. 26(2), 192-199 (2004).
    • (2004) Ther. Drug Monit. , vol.26 , Issue.2 , pp. 192-199
    • Wojnowski, L.1
  • 82
    • 0038508970 scopus 로고    scopus 로고
    • The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
    • Clarke TA, Waskell LA: The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab. Dispos. 31(1), 53-59 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , Issue.1 , pp. 53-59
    • Clarke, T.A.1    Waskell, L.A.2
  • 83
    • 0035217180 scopus 로고    scopus 로고
    • The genetic determinants of the CYP3A5 polymorphism
    • Hustert E, Haberl M, Burk O et al.: The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics 11(9), 773-779 (2001).
    • (2001) Pharmacogenetics , vol.11 , Issue.9 , pp. 773-779
    • Hustert, E.1    Haberl, M.2    Burk, O.3
  • 84
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • Lamba JK, Lin YS, Schuetz EG, Thummel KE: Genetic contribution to variable human CYP3A-mediated metabolism. Adv. Drug Deliv. Rev. 54(10), 1271-1294 (2002).
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , Issue.10 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 86
    • 33646007060 scopus 로고    scopus 로고
    • Pharmacogenetic modulation of clopidogrel antiplatelet effects: Role of gene sequence variations of the CYP3A4 enzyme
    • Stockholm, Sweden, 3-7 September (Abstract P3510)
    • Angiolillo DJ, Bernardo E, Ramirez C et al.: Pharmacogenetic modulation of clopidogrel antiplatelet effects: role of gene sequence variations of the CYP3A4 enzyme. Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract P3510).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Angiolillo, D.J.1    Bernardo, E.2    Ramirez, C.3
  • 87
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction
    • Lau WC, Waskell LA, Watkins PB et al.: Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. Circulation 107, 32-37 (2003).
    • (2003) Circulation , vol.107 , pp. 32-37
    • Lau, W.C.1    Waskell, L.A.2    Watkins, P.B.3
  • 88
    • 0141986521 scopus 로고    scopus 로고
    • Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function - A flow cytometry study
    • Neubauer H, Gunesdogan B, Hanefeld C, Spiecker M, Mugge A: Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function - a flow cytometry study. Eur. Heart J. 24(19), 1744-1749 (2003).
    • (2003) Eur. Heart J. , vol.24 , Issue.19 , pp. 1744-1749
    • Neubauer, H.1    Gunesdogan, B.2    Hanefeld, C.3    Spiecker, M.4    Mugge, A.5
  • 89
    • 0042780283 scopus 로고    scopus 로고
    • Clopidogrel for the reduction of events during observation investigators: Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial
    • Saw J, Steinhubl SR. Berger PB et al.: Clopidogrel for the reduction of events during observation investigators: lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation 108(8), 921-924 (2003).
    • (2003) Circulation , vol.108 , Issue.8 , pp. 921-924
    • Saw, J.1    Steinhubl, S.R.2    Berger, P.B.3
  • 90
    • 6344226832 scopus 로고    scopus 로고
    • Absence of interaction between atorvastatin or other statins and clopidogrel: Results from the interaction study
    • Serebruany VL, Midei MG, Malinin AI et al.: Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study. Arch. Intern. Med. 164(18), 2051-2057 (2004).
    • (2004) Arch. Intern. Med. , vol.164 , Issue.18 , pp. 2051-2057
    • Serebruany, V.L.1    Midei, M.G.2    Malinin, A.I.3
  • 91
    • 0037382774 scopus 로고    scopus 로고
    • Are antiplatelet effects of clopidogrel inhibited by atorvastatin? A research question formulated but not yet adequately tested
    • Serebruany VL, Steinhubl SR, Hennekens CH: Are antiplatelet effects of clopidogrel inhibited by atorvastatin? A research question formulated but not yet adequately tested. Circulation 107(12), 1568-1569 (2003).
    • (2003) Circulation , vol.107 , Issue.12 , pp. 1568-1569
    • Serebruany, V.L.1    Steinhubl, S.R.2    Hennekens, C.H.3
  • 92
    • 23744463417 scopus 로고    scopus 로고
    • Clopidogrel 'resistance' and statin cotreatment - Significant for cardiocoronary prevention in real life?
    • Schror K, Weber AA, Hohlfeld T: Clopidogrel 'resistance' and statin cotreatment - significant for cardiocoronary prevention in real life? Thromb. Haemost. 94(2), 235-237 (2005).
    • (2005) Thromb. Haemost. , vol.94 , Issue.2 , pp. 235-237
    • Schror, K.1    Weber, A.A.2    Hohlfeld, T.3
  • 93
    • 33646569711 scopus 로고    scopus 로고
    • No impact of statins metabolised by CYP3A4 on the antiplatelet effect and the clinical outcome after a 600 mg loading dose of clopidogrel in patients undergoing elective coronary angiography
    • Stockholm, Sweden, 3-7 September (Abstract 2952)
    • Hochholzer W, Trenk D, Frundi D et al.: No impact of statins metabolised by CYP3A4 on the antiplatelet effect and the clinical outcome after a 600 mg loading dose of clopidogrel in patients undergoing elective coronary angiography: Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract 2952).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Hochholzer, W.1    Trenk, D.2    Frundi, D.3
  • 94
    • 0042859862 scopus 로고    scopus 로고
    • Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subject
    • Fontana P, Dupont A, Gandrille S et al.: Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subject. Circulation 108, 989-995 (2003).
    • (2003) Circulation , vol.108 , pp. 989-995
    • Fontana, P.1    Dupont, A.2    Gandrille, S.3
  • 95
    • 0346365089 scopus 로고    scopus 로고
    • P2Y12 H2 haplotype is associated with peripheral artery disease: A case-control study
    • Fontana P, Gaussems P, Aiach M, Fiessinger JN, Emmerich J, Reny JL: P2Y12 H2 haplotype is associated with peripheral artery disease: a case-control study. Circulation 108, 2971-2973 (2003).
    • (2003) Circulation , vol.108 , pp. 2971-2973
    • Fontana, P.1    Gaussems, P.2    Aiach, M.3    Fiessinger, J.N.4    Emmerich, J.5    Reny, J.L.6
  • 96
    • 24944465039 scopus 로고    scopus 로고
    • Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease
    • Angiolillo D, Fernandez-Ortiz A, Bernardo E et al.: Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb. Res. (2005).
    • (2005) Thromb. Res.
    • Angiolillo, D.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 97
    • 33646576938 scopus 로고    scopus 로고
    • P2Y12 receptor polymorphism and clopidogrel response: Is there a link?
    • 3-7 September Stockholm, Sweden (Abstract P3514)
    • Angiolillo DJ, Bernardo E, Ramirez C et al.: P2Y12 receptor polymorphism and clopidogrel response: is there a link? Eur. Soc. Cardiol. Congr 3-7 September 2005, Stockholm, Sweden (Abstract P3514).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Angiolillo, D.J.1    Bernardo, E.2    Ramirez, C.3
  • 98
    • 17444429227 scopus 로고    scopus 로고
    • P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose
    • von Beckerath N, von Beckerath O, Koch W, Eichinger M, Schomig A, Kastrati A: P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul. Fibrinolysis 16(3), 199-204 (2005).
    • (2005) Blood Coagul. Fibrinolysis , vol.16 , Issue.3 , pp. 199-204
    • von Beckerath, N.1    von Beckerath, O.2    Koch, W.3    Eichinger, M.4    Schomig, A.5    Kastrati, A.6
  • 99
    • 1542358994 scopus 로고    scopus 로고
    • Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: Implications for thrombotic events and restenosis
    • Gurbel PA, Samara WM, Bliden KP: Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis. Platelets 15, 95-99 (2004).
    • (2004) Platelets , vol.15 , pp. 95-99
    • Gurbel, P.A.1    Samara, W.M.2    Bliden, K.P.3
  • 100
    • 0030053912 scopus 로고    scopus 로고
    • Platelet function in acute myocardial infarction treated with direct angioplasty
    • Gawaz M, Neumann FJ, Ott I, Schiessler A, Schömig A: Platelet function in acute myocardial infarction treated with direct angioplasty. Circulation 93(2), 229-237 (1996).
    • (1996) Circulation , vol.93 , Issue.2 , pp. 229-237
    • Gawaz, M.1    Neumann, F.J.2    Ott, I.3    Schiessler, A.4    Schömig, A.5
  • 101
    • 1542358994 scopus 로고    scopus 로고
    • Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: Implications for thrombotic events and restenosis
    • Gurbel PA, Samara WM, Bliden KP: Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis. Platelets 15, 95-99 (2004).
    • (2004) Platelets , vol.15 , pp. 95-99
    • Gurbel, P.A.1    Samara, W.M.2    Bliden, K.P.3
  • 103
    • 0141885290 scopus 로고    scopus 로고
    • Pathological mechanisms of fatal late coronary stent thrombosis in humans
    • Farb A, Burke AP, Kolodgie FD, Virmani R: Pathological mechanisms of fatal late coronary stent thrombosis in humans. Circulation 108(14), 1701-1706 (2003).
    • (2003) Circulation , vol.108 , Issue.14 , pp. 1701-1706
    • Farb, A.1    Burke, A.P.2    Kolodgie, F.D.3    Virmani, R.4
  • 104
    • 10744221922 scopus 로고    scopus 로고
    • Incidence, mechanism, predictors, and long-term prognosis of late stent malapposition after bare-metal stent implantation
    • Hong MK, Mintz GS, Lee CW et al.: Incidence, mechanism, predictors, and long-term prognosis of late stent malapposition after bare-metal stent implantation. Circulation 109(7), 881-886 (2004).
    • (2004) Circulation , vol.109 , Issue.7 , pp. 881-886
    • Hong, M.K.1    Mintz, G.S.2    Lee, C.W.3
  • 105
    • 23644433510 scopus 로고    scopus 로고
    • Platelet function profiles in patients with Type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al.: Platelet function profiles in patients with Type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 54(8), 2430-2435 (2005).
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2430-2435
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 106
    • 21044457137 scopus 로고    scopus 로고
    • Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus
    • Watala C: Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus. Curr. Pharm. Des. 11(18), 2331-2365 (2005).
    • (2005) Curr. Pharm. Des. , vol.11 , Issue.18 , pp. 2331-2365
    • Watala, C.1
  • 107
    • 6344235272 scopus 로고    scopus 로고
    • Platelet function, coagulopathy, and impaired fibrinolysis in diabetes
    • Sobel BE, Schneider DJ: Platelet function, coagulopathy, and impaired fibrinolysis in diabetes. Cardiol. Clin. 22(4), 511-526 (2004).
    • (2004) Cardiol. Clin. , vol.22 , Issue.4 , pp. 511-526
    • Sobel, B.E.1    Schneider, D.J.2
  • 108
    • 2042504400 scopus 로고    scopus 로고
    • Reduced sensitivity of platelets from Type 2 diabetic patients to acetylsalicylic acid (aspirin) - Its relation to metabolic control
    • Watala C, Golanski J, Pluta J et al.: Reduced sensitivity of platelets from Type 2 diabetic patients to acetylsalicylic acid (aspirin) - its relation to metabolic control. Thromb. Res. 113(2), 101-113 (2004).
    • (2004) Thromb. Res. , vol.113 , Issue.2 , pp. 101-113
    • Watala, C.1    Golanski, J.2    Pluta, J.3
  • 109
    • 19644370724 scopus 로고    scopus 로고
    • Superior responder rate for inhibition of platelet aggregation with a 60 mg loading dose of prasugrel (CS-747, LY640315) compared with a 300 mg loading dose of clopidogrel
    • Brandt JT, Payne CD, Weerakkody G et al.: Superior responder rate for inhibition of platelet aggregation with a 60 mg loading dose of prasugrel (CS-747, LY640315) compared with a 300 mg loading dose of clopidogrel. J. Am. Coll. Cardiol. 45(Suppl. 1), 87A (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.45 , Issue.SUPPL. 1
    • Brandt, J.T.1    Payne, C.D.2    Weerakkody, G.3
  • 110
    • 21044459487 scopus 로고    scopus 로고
    • A comparison of prasugrel (CS-747, LY640315) with clopidogrel on platelet function in healthy male volunteers
    • Asai F, Jakubowski JA, Winters KJ et al.: A comparison of prasugrel (CS-747, LY640315) with clopidogrel on platelet function in healthy male volunteers. J. Am. Coll. Cardiol. 45(Suppl. 1), 87A (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.45 , Issue.SUPPL. 1
    • Asai, F.1    Jakubowski, J.A.2    Winters, K.J.3
  • 111
    • 24144437717 scopus 로고    scopus 로고
    • 12 receptor antagonist, compared with clopidogrel in aspirin-treated patients with atherosclerotic vascular disease
    • 12 receptor antagonist, compared with clopidogrel in aspirin-treated patients with atherosclerotic vascular disease. J. Am. Coll. Cardiol. 45(Suppl. 1), 416A (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.45 , Issue.SUPPL. 1
    • Wallentin, L.1    Jernberg, T.2    Leese, P.T.3
  • 112
    • 33645962863 scopus 로고    scopus 로고
    • Greater and less variable inhibition of platelet aggregation (IPA) with AZD6140, the first oral reversible ADP receptor antagonist, compared with clopidogrel in patients with atherosclerosis
    • Stockholm, Sweden, 3-7 September (Abstract 3764)
    • Husted S, Emanuelsson H, Heptinstall S, Clark S, Peters G: Greater and less variable inhibition of platelet aggregation (IPA) with AZD6140, the first oral reversible ADP receptor antagonist, compared with clopidogrel in patients with atherosclerosis. Eur. Soc. Cardiol. Congr. Stockholm, Sweden, 3-7 September 2005, (Abstract 3764).
    • (2005) Eur. Soc. Cardiol. Congr.
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Clark, S.4    Peters, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.