The pursuit of cryptococcal pathogenesis: Heterologous hosts and the study of cryptococcal host-pathogen interactions

FEMS Yeast Research

Volumn 6, Issue 4, 2006, Pages 567-573

  London, Roanna ^a   Orozco, Benjamin Samuel ^a   Mylonakis, Eleftherios ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Caenorhabditis elegans; Cryptococcus neoformans; Drosophila melanogaster; Fungal infection; Galleria mellonella; Toll pathway

Indexed keywords

ACANTHAMOEBA CASTELLANII; CAENORHABDITIS ELEGANS; CRYPTOCOCCOSIS; CRYPTOCOCCUS; CRYPTOCOCCUS NEOFORMANS; DICTYOSTELIUM DISCOIDEUM; DROSOPHILA MELANOGASTER; FUNGAL GENE; FUNGAL VIRULENCE; GALLERIA MELLONELLA; HOST PATHOGEN INTERACTION; HOST RESISTANCE; INVERTEBRATE; MAMMAL; MUTANT; NONHUMAN; SHORT SURVEY;

ANIMALS; CAENORHABDITIS ELEGANS; CRYPTOCOCCUS NEOFORMANS; DROSOPHILA MELANOGASTER; HUMANS; MOTHS; VIRULENCE;

ACANTHAMOEBA CASTELLANII; CAENORHABDITIS ELEGANS; DICTYOSTELIUM DISCOIDEUM; DROSOPHILA MELANOGASTER; FILOBASIDIELLA NEOFORMANS; GALLERIA MELLONELLA; INVERTEBRATA; MAMMALIA;

EID: 33646545663     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00056.x     Document Type: Short Survey

References (36)

1. Alarco AM Marcil A Chen J Suter B Thomas D Whiteway M 2004 Immune-deficient Drosophila melanogaster a model for the innate immune response to human fungal pathogens J Immunol 172 5622 5628
2. Apidianakis Y Rahme LG Heitman J Ausubel FM Calderwood SB Mylonakis E 2004 Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response Eukaryot Cell 3 413 419
3. Apidianakis Y Mindrinos MN Xiao W Lau GW Baldini RL Davis RW Rahme LG 2005 Profiling early infection responses Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression Proc Natl Acad Sci USA 102 2573 2578
4. Bergin D Brennan M Kavanagh K 2003 Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella Microbes Infect 5 1389 1395
5. Bergin D Reeves EP Renwick J Wientjes FB Kavanagh K 2005 Superoxide production in Galleria mellonella hemocytes identification of proteins homologous to the NADPH oxidase complex of human neutrophils Infect Immun 73 4161 4170
6. Bhabhra R Miley MD Mylonakis E et al 2004 Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence Infect Immun 72 4731 4740
7. Brennan M Thomas DY Whiteway M Kavanagh K 2002 Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae FEMS Immunol Med Microbiol 34 153 157
8. Casadevall A 2005 Host as the variable model hosts approach the immunological asymptote Infect Immun 73 3829 3832
9. Couillault C Pujol N Reboul J Sabatier L Guichou JF Kohara Y Ewbank JJ 2004 TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM Nat Immunol 5 488 494
10. Dunphy GB Oberholzer U Whiteway M Zakarian RJ Boomer I 2003 Virulence of Candida albicans mutants toward larval Galleria mellonella (Insecta, Lepidoptera, Galleridae) Can J Microbiol 49 514 524
11. Irving P Ubeda JM Doucet D et al 2005 New insights into Drosophila larval haemocyte functions through genome-wide analysis Cell Microbiol 7 335 350
12. Kavanagh K Reeves EP 2004 Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens FEMS Microbiol Rev 28 101 112
13. Kim DH Feinbaum R Alloing G et al 2002 A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity Science 297 623 626
14. Lemaitre B Nicolas E Michaut L Reichhart JM Hoffmann JA 1996 The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 973 983
15. Levitz SM 2001 Does amoeboid reasoning explain the evolution and maintenance of virulence factors in Cryptococcus neoformans? Proc Natl Acad Sci USA 98 14760 14762
16. Liberati NT Fitzgerald KA Kim DH Feinbaum R Golenbock DT Ausubel FM 2004 Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response Proc Natl Acad Sci USA 101 6593 6598
17. Mahajan-Miklos S Rahme LG Ausubel FM 2000 Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts Mol Microbiol 37 981 988
18. Mylonakis E Aballay A 2005 Worms and flies as genetically tractable animal models to study host-pathogen interactions Infect Immun 73 3833 3841
19. Mylonakis E Ausubel FM Perfect JR Heitman J Calderwood SB 2002 Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis Proc Natl Acad Sci USA 99 15675 15680
20. Mylonakis E Idnurm A Moreno R et al 2004 Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals Mol Microbiol 54 407 419
21. Mylonakis E Moreno R El Khoury JB et al 2005 Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis Infect Immun 73 3842 3850
22. Nielsen K Cox GM Wang P Toffaletti DL Perfect JR Heitman J 2003 Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates Infect Immun 71 4831 4841
23. del Poeta M Toffaletti DL Rude TH Sparks SD Heitman J Perfect JR 1999 Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein Can J Microbiol 49 514 524
24. Rahme LG Ausubel FM Cao H et al 2000 Plants and animals share functionally common bacterial virulence factors Proc Natl Acad Sci USA 97 8815 8821
25. Reeves EP Messina CG Doyle S Kavanagh K 2004 Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella Mycopathologia 158 73 79
26. Schuhmann B Seitz V Vilcinskas A Podsiadlowski L 2003 Cloning and expression of gallerimycin, an antifungal peptide expressed in immune response of greater wax moth larvae, Galleria mellonella Arch Insect Biochem Physiol 53 125 133
27. Slepneva IA Komarov DA Glupov VV Serebrov VV Khramtsov VV 2003 Influence of fungal infection on the DOPA-semiquinone and DOPA-quinone production in haemolymph of Galleria mellonella larvae Biochem Biophys Res Commun 300 188 191
28. St Leger RJ Screen SE Shams-Pirzadeh B 2000 Lack of host specialization in Aspergillus flavus Appl Environ Microbiol 66 320 324
29. Steenbergen JN Casadevall A 2003 The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans Microbes Infect 5 667 675
30. Steenbergen JN Nosanchuk JD Malliaris SD Casadevall A 2003 Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum Infect Immun 71 4862 4872
31. Steenbergen JN Shuman HA Casadevall A 2001 Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages Proc Natl Acad Sci USA 98 15245 15250
32. Tan MW Mahajan-Miklos S Ausubel FM 1999a Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis Proc Natl Acad Sci USA 96 715 720
33. Tan MW Rahme LG Sternberg JA Tompkins RG Ausubel FM 1999b Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors Proc Natl Acad Sci USA 96 2408 2413
34. Tang RJ Breger J Idnurm A et al 2005 Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a C. elegans progeny-based screen Infect Immun 73 8219 8225
35. Thomas CJ Lee JY Conn LA et al 1998 Surveillance of cryptococcosis in Alabama, 1992-1994 Ann Epidemiol 8 212 216
36. Zettervall CJ Anderl I Williams MJ Palmer R Kurucz E Ando I Hultmark D 2004 A directed screen for genes involved in Drosophila blood cell activation Proc Natl Acad Sci USA 101 14192 14197