Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract

Archives of Toxicology

Volumn 80, Issue 6, 2006, Pages 319-327

  Young, Shun Chieh ^a   Wang, Chau Jong ^a   Hsu, Jeng Dong ^b   Hsu, Jui Ling ^a   Chou, Fen Pi ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cisplatin; Glutathione S transferase; Multidrug resistance protein 2; Piper betel leaf

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BETEL EXTRACT; CISPLATIN; COMPLEMENTARY DNA; EUGENOL; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; OXALIPLATIN; PLANT EXTRACT;

ARTICLE; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRADITIONAL MEDICINE;

ANTINEOPLASTIC AGENTS; CELL FRACTIONATION; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; EUGENOL; G2 PHASE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; HUMANS; ISOENZYMES; LIVER NEOPLASMS; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANOPLATINUM COMPOUNDS; PIPER BETLE; PLANT EXTRACTS; PLANT LEAVES;

PIPER BETEL;

EID: 33646537819     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0051-3     Document Type: Article

References (38)

1. Allan JM, Wild CP, Rollinson S, Willett EV, Moorman AV, Dovey GJ, Roddam PL, Roman E, Cartwright RA, Morgan GJ (2001) Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc Nat Acad Sci 98:11592-11597
2. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48:589-601
3. Amonkar AJ, Padma PR, Bhide SV (1989) Protection effect of hydroxychavicol, a phenolic component of betel leaf, against the tobacco-specific carcinogens. Mut Res 210:249-253
4. Arruda VR, Lima CS, Grignoli CR, Melo MB, Lorand-Metze I, Alberto FL, Saad ST, Costa FF (2001) Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects. Eur J Haematol 66:383-388
5. Azuine MA, Amonkar AJ, Bhide SV (1991) Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin. Ind J Exp Biol 29:346-351
6. Azuine MA, Bhide SV (1992) Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis. Int J Cancer 51:412-415
7. Batist G, Tulpule A, Sinha BK, Katki AG, Myers CE, Cowan KH (1986) Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J Biol Chem 261:15544-15549
8. Calvert P, Yao KS, Hamilton TC, O'Dwyer PJ (1998) Clinical studies of reversal of drug resistance based on glutathione. Chem Biol Interact 111-112:213-224
9. Cheng X, Kigawa J, Minagawa Y, Kanamori Y, Itamochi H, Okada M, Terakawa N (1997) Glutathione S-transferase-pi expression and glutathione concentration in ovarian carcinoma before and after chemotherapy. Cancer 79:521-527
10. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
11. Choudhary D, Kale RK (2002) Antioxidant and non-toxic properties of piper belle leaf extract: in vitro and in vivo studies. Phytother Res 16:461-466
12. Habig WH, Pabst MT, Jakoby WB (1974) Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
13. Harada S, Tachikawa H, Kawanishi Y (2001) Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia. Biochem Biophys Res Commun 281:267-271
14. Hengstler JG, Böttger T, Tanner B, Dietrich B, Henrich M, Knapstein PG, Junginger T, Oesch F (1998) Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases α and π, glutathione and aldehyde dehydrogenase. Cancer Lett 128:105-112
15. Inoue T, Ishida T, Sugio K, Maehara Y, Sugimachi K (1995) Glutathione S-transferase pi is a powerful indicator in chemotherapy of human lung squamous cell carcinoma. Respiration 62:223-227
16. Kauffmann HM, Keepler D, Kartenbeck J, Schrenk D (1997) Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in hepatocytes. Hepatology 26:980-985
17. Keppler D, Cui Y, Konig J, Leier I, Nies A (1999) Export pumps for anionic conjugates encoded by MRP genes. Adv Enzyme Regul 39:237-246
18. Kitahara A, Satoh K, Nishimura K, Ishikawa T, Ruike K, Sato K, Tsuda H, Ito N (1984) Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res 44:2698-2703
19. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC (1995) Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 24:450-453
20. Kool M, Haas M, Schefler GL, Scheffer RJ, Eijk MJT, Juijn JA, Bass F, Borst P (1997) Analysis of expression CMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547
21. Lear JT, Heagerty AHM, Smith A, Bowers B, Payne C, Smith CA, Jones PW, Gilford J, Yengi L, Alldersea J, Fryer AA, Strange RC (1996) Multiple cutaneous basal cell carcinomas: glutathione-S transferase (GSTM1, GSTT1) and cytochrome P-450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis 17:1891-1896
22. Mannervik B (1985) The isozymes of glutathione transferase. Adv Enzymol Relat Areas Mol Biol 57:357-417
23. Meyer DJ, Beale D, Tan KH, Coles B, Ketterer B (1985) Glutathione transferase in primary rat hepatomas: the isolation of a form with GSH peroxidase activity. FEBS Lett 184:139-143
24. Mistry P, Kelland LR, Abel G, Sidhar S, Harrap KR (1991) The relationships between glutathione, glutathione S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer 64:215-220
25. Morrow CS, Smitherman PK, Diah SK, Schneider E, Townsend AJ (1998) Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in anti-neoplastic drug detoxification. J Biol Chem 273:20114-20120
26. Padma PR, Lalitha VS, Amonkar AJ, Bhide SV (1989) Anticarcinogenic effect of betel leaf extract against tobacco carcinogens. Cancer Lett 45:195-202
27. Rebbeck TR (1997) Molecular epidemiology of the human glutathione-S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev 6:733-743
28. Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003) Flavonoids: promising anticancer agents. Med Res Rev 23:519-534
29. Rompelberg CJ, Ploemen JH, Jespersen S, Greef J, Verhagen H, Bladeren PJ (1996) Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products. Chem Biol Interact 99:85-97
30. Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM (2001) Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett 120:51-57
31. Smitherman PK, Townsend AJ, Kute TE, Morrow CS (2004) Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther 308(1):260-267
32. Stoehlmacher J, Park DJ, Zhang W, Groshen S, Tsao-Wei DD, Yu MC, Lenz HJ (2002) Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. J Natl Cancer Inst 94(12):936-942
33. Strange RC, Spiteri MA, Ramachandran S, Fryer AA (2001) Glutathione-S-transferase family of enzymes. Mutat Res 482:21-26
34. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M (1996) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistance human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129
35. Trivedi AH, Patel RK, Rawal UM, Adhvaryu SG, Balar DB (1994) Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala. Neoplasma 41:177-181
36. Vernhet L, Allain N, Le Vee M, Morel F, Guillouzo A, Fardel O (2003) Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. J Pharmacol Exp Ther 304(1):145-155
37. Yang Y, Cheng JZ, Singhal SS, Saini M, Pandya U, Awasthi S, Awasthi YC (2001) Role of Glutathione S-Transferases in Protection against Lipid Peroxidation. J Biol Chem 276:19220-19230
38. Zhang Y, Zuo GQ, Tang WX (2004) Study on apoptosis of human hepatoma cell line HepG2 induced by oxaliplatin. Zhonghua Gan Zang Bing Za Zhi 12(6):374-375