Changes in expression of N-methyl-D-aspartate receptor subunits occur early in the R6/2 mouse model of Huntington's disease

Developmental Neuroscience

Volumn 28, Issue 3, 2006, Pages 230-238

  Ali, Noore J ^a   Levine, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Huntington's disease; N methyl D aspartate receptors; R6 2 mouse model; Receptor subunit; RNA; Single cell RT PCR

Indexed keywords

ENKEPHALIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RECEPTOR SUBUNIT; SUBSTANCE P;

ADOLESCENT; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; EXCITOTOXICITY; HUNTINGTON CHOREA; MOUSE; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; NEURONS; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33646518995     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091921     Document Type: Article

References (41)

1. Albin RL, Young AB, Penney JB (1989): The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375.
2. Ariano MA, Wagle N, Grissell AE (2005): Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes. J Neurosci Res 80:634-645.
3. Beal MF, Hyman BT, Koroshetz W (1993): Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 16:125-131.
4. Behe P, Stern P, Wyllie DJ, Nassar M, Schoepfer R, Colquhoun D (1995): Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proc R Soc Lond B Biol Sci 262:205-213.
5. Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Horiuchi A, Nairn AC, Messer A, Greengard P (2000): Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. Proc Natl Acad Sci USA 97:6809-6814.
6. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA (1995): Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
7. Bordelon YM, Chesselet MF (1999): Early effects of intrastriatal injections of quinolinic acid on microtubule-associated protein-2 and neuropeptides in rat basal ganglia. Neuroscience 93:843-853.
8. Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999): Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci 19:3248-3257.
9. Cepeda C, Ariano MA, Calvert CR, Flores-Hernandez J, Chandler SH, Leavitt BR, Hayden MR, Levine MS (2001a): NMDA receptor function in mouse models of Huntington disease. J Neurosci Res 66:525-539.
10. Cepeda C, Hurst RS, Calvert CR, Hernandez-Echeagaray E, Nguyen OK, Jocoy E, Christian LJ, Ariano MA, Levine MS (2003): Transient and progressive electrophysiologjcal alterations in the corticostriatal pathway in a mouse model of Huntington's disease. J Neurosci 23:961-969.
11. Cepeda C, Itri JN, Flores-Hernandez J, Hurst RS, Calvert CR, Levine MS (2001b): Differential sensitivity of medium- and large-sized striatal neurons to NMDA but not kainate receptor activation in the rat. Eur J Neurosci 14:1577-1589.
12. Cha JH, Frey AS, Alsdorf SA, Kerner JA., Kosinski CM, Mangiarini L, Penney JB Jr, Davies SW, Bates GP, Young AB (1999): Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease. Philos Trans R Soc Lond B Biol Sci 354:981-989.
13. Cha JH, Kosinski CM, Kerner JA, Alsdorf SA, Mangiarini L, Davies SW, Penney JB, Bates GP, Young AB (1998): Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc Natl Acad Sci USA 95:6480-6485.
14. Chapman DE, Keefe KA, Wilcox KS (2003): Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. J Neurophysiol 89:69-80.
15. Coyle JT (1979): An animal model for Huntington's disease. Biol Psychiatry 14:251-276.
16. Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, Scherzinger E, Wanker EE, Mangiarini L, Bates GP (1997): Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90:537-548.
17. Davies SW, Turmaine, M, Cozens BA, Raza AS, Mahal A, Mangiarini L, Bates GP (1999): From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease. Philos Trans R Soc Lond B Biol Sci 354:981-989.
18. DiFiglia M (1990): Excitotoxic injury of the neostriatum: a model for Huntington's disease. Trends Neurosci 13:286-289.
19. Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D (2002): Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science 296:2238-2243.
20. Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF (2000): Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 20:4389-4397.
21. Hollmann M, Boulter J, Maron C, Heinemann S (1994): Molecular biology of glutamate receptors. Potentiation of N-methyl-D-aspartate receptor splice variants by zinc. Ren Physiol Biochem 17:182-183.
22. Klapstein GJ, Fisher RS, Zanjani H, Cepeda C, Jokel ES, Chesselet MF, Levine MS (2001): Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. J Neurophysiol 86:2667-2677.
23. Kumar SS, Huguenard JR (2003): Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci 31:10074-10083.
24. Laforet GA, Sapp E, Chase K, McIntyre C, Boyce FM, Campbell M, Cadigan BA, Warzecki L, Tagle DA, Reddy PH, Cepeda C, Calvert CR, Jokel ES, Klapstein GJ, Ariano MA, Levine MS, DiFiglia M, Aronin N (2001): Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J Neurosci 21:9112-9123.
25. Levine MS, Klapstein GJ, Koppel A, Gruen E, Cepeda C, Vargas ME, Jokel ES, Carpenter EM, Zanjani H, Hurst RS, Efstratiadis A, Zeitlin S, Chesselet MF (1999): Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease. J Neurosci Res 58:515-532.
26. Li H, Li SH, Johnston H, Shelbourne PF, Li XJ (2000): Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat Genet 25:385-389.
27. Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA (2003): Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiol Aging 24:1113-1121.
28. Lione LA, Carter RJ, Hunt MJ, Bates GP, Morton AJ, Dunnett SB (1999): Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation. J Neurosci 19:10428-10437.
29. Luthi-Carter R, Apostol BL, Dunah AW, DeJohn MM, Farrell LA, Bates GP, Young AB, Standaert DG, Thompson LM, Cha JH (2003): Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Neurobiol Dis 14:624-636.
30. Luthi-Carter R, Strand A, Peters NL, Solano SM, Hollingsworth ZR, Menon AS, Frey AS, Spektor BS., Penney EB, Schilling G, Ross CA, Borchelt DR, Tapscott SJ, Young AB, Cha JH, Olson JM (2000): Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9:1259-1271.
31. Martin JB, Gusella JF (1986): Huntington's disease. Pathogenesis and management. N Engl J Med 315:267-1276.
32. Menalled L, Zanjani H, MacKenzie L, Koppel A, Carpenter E, Zeitlin S, Chesselet MF (2000): Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease. Exp Neurol 162:328-342.
33. Murphy KP, Carter RJ, Lione LA, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (2000): Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation. J Neurosci 20:5115-5123.
34. 2+. J Physiol 562:319-331.
35. Sathasivam K, Hobbs C, Mangiarini L, Mahal A, Turmaine M, Doherty P, Davies SW, Bates GP (1999): Transgenic models of Huntington's disease. Philos Trans R Soc Lond B Biol Sci 354:963-969.
36. Schwarcz R, Foster AC, French ED, Whetsell WO Jr, Kohler C (1984): Excitotoxic models for neurodegenerative disorders. Life Sci 35:19-32.
37. Starling AJ, Cepeda C, de Lima M, Chandler SH, Levine MS (2005): Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease. J Neurosci Res 82:377-386.
38. Vonsattel JP, DiFiglia M (1998): Huntington disease. J Neuropathol Exp Neurol 57:369-384.
39. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr (1985): Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol 44:559-577.
40. Zeron MM, Chen N, Moshaver A, Lee AT, Wellington CL, Hayden MR, Raymond LA (2001): Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci 17:41-53.
41. Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA (2002): Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 33:849-860.