메뉴 건너뛰기




Volumn 126, Issue 1-2 SPEC. ISS., 2005, Pages 11-19

Ghrelin: A gastric peptide that regulates food intake and energy homeostasis

Author keywords

GH; Ghrelin; GHS; GHS R

Indexed keywords

AMINO ACID; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR;

EID: 11144262776     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2004.08.007     Document Type: Review
Times cited : (124)

References (68)
  • 1
    • 0345151982 scopus 로고    scopus 로고
    • The anterior pituitary
    • P.R. Larsen H.M. Kronenberg S. Melmed K.S. Polonsky Saunders Philadelphia
    • S. Melmed, and D.L. Kleimberg The anterior pituitary P.R. Larsen H.M. Kronenberg S. Melmed K.S. Polonsky Williams Textbook of Endocrinology 2003 Saunders Philadelphia 219 230
    • (2003) Williams Textbook of Endocrinology , pp. 219-230
    • Melmed, S.1    Kleimberg, D.L.2
  • 2
    • 0018899801 scopus 로고
    • Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro
    • C.Y. Bowers, F. Momany, G.A. Reynolds, D. Chang, A. Hong, and K. Chang Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro Endocrinology 106 1980 663 667
    • (1980) Endocrinology , vol.106 , pp. 663-667
    • Bowers, C.Y.1    Momany, F.2    Reynolds, G.A.3    Chang, D.4    Hong, A.5    Chang, K.6
  • 3
    • 0019352943 scopus 로고
    • Design, synthesis, and biological activity of peptides which release growth hormone in vitro
    • F.A. Momany, C.Y. Bowers, G.A. Reynolds, D. Chang, A. Hong, and K. Newlander Design, synthesis, and biological activity of peptides which release growth hormone in vitro Endocrinology 108 1981 31 39
    • (1981) Endocrinology , vol.108 , pp. 31-39
    • Momany, F.A.1    Bowers, C.Y.2    Reynolds, G.A.3    Chang, D.4    Hong, A.5    Newlander, K.6
  • 7
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 8
    • 0031573862 scopus 로고    scopus 로고
    • Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors
    • K.K. McKee, C.P. Tan, O.C. Palyha, J. Liu, S.D. Feighner, and D.L. Hreniuk Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors Genomics 46 1997 426 434
    • (1997) Genomics , vol.46 , pp. 426-434
    • McKee, K.K.1    Tan, C.P.2    Palyha, O.C.3    Liu, J.4    Feighner, S.D.5    Hreniuk, D.L.6
  • 11
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc. Natl. Acad. Sci. U. S. A. 101 2004 4679 4684
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 13
    • 0035320623 scopus 로고    scopus 로고
    • Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    • M. Kojima, H. Hosoda, H. Matsuo, and K. Kangawa Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor Trends Endocrinol. Metab. 12 2001 118 122
    • (2001) Trends Endocrinol. Metab. , vol.12 , pp. 118-122
    • Kojima, M.1    Hosoda, H.2    Matsuo, H.3    Kangawa, K.4
  • 14
    • 0034698072 scopus 로고    scopus 로고
    • Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
    • H. Hosoda, M. Kojima, H. Matsuo, and K. Kangawa Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor J. Biol. Chem. 275 2000 21995 22000
    • (2000) J. Biol. Chem. , vol.275 , pp. 21995-22000
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 17
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M.S. Mondal, and T. Suganuma Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans Endocrinology 141 2000 4255 4261
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6
  • 18
    • 0030893597 scopus 로고    scopus 로고
    • Physiology of isolated gastric endocrine cells
    • G. Sachs, N. Zeng, and C. Prinz Physiology of isolated gastric endocrine cells Annu. Rev. Physiol. 59 1997 243 256
    • (1997) Annu. Rev. Physiol. , vol.59 , pp. 243-256
    • Sachs, G.1    Zeng, N.2    Prinz, C.3
  • 21
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Y. Date, N. Murakami, K. Toshinai, S. Matsukura, A. Niijima, and H. Matsuo The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats Gastroenterology 123 2002 1120 1128
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3    Matsukura, S.4    Niijima, A.5    Matsuo, H.6
  • 23
    • 17944364819 scopus 로고    scopus 로고
    • A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans
    • Y. Hataya, T. Akamizu, K. Takaya, N. Kanamoto, H. Ariyasu, and M. Saijo A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans J. Clin. Endocrinol. Metab. 86 2001 4552 4555
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4552-4555
    • Hataya, Y.1    Akamizu, T.2    Takaya, K.3    Kanamoto, N.4    Ariyasu, H.5    Saijo, M.6
  • 24
    • 0034878898 scopus 로고    scopus 로고
    • Regulation of the ghrelin gene: Growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary
    • J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and S. Oikawa Regulation of the ghrelin gene: growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary Endocrinology 142 2001 4154 4157
    • (2001) Endocrinology , vol.142 , pp. 4154-4157
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Oikawa, S.6
  • 27
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 28
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • A.M. Wren, C.J. Small, H.L. Ward, K.G. Murphy, C.L. Dakin, and S. Taheri The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion Endocrinology 141 2000 4325 4328
    • (2000) Endocrinology , vol.141 , pp. 4325-4328
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3    Murphy, K.G.4    Dakin, C.L.5    Taheri, S.6
  • 29
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 30
    • 0036263016 scopus 로고    scopus 로고
    • Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity
    • Y. Shuto, T. Shibasaki, A. Otagiri, H. Kuriyama, H. Ohata, and H. Tamura Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity J. Clin. Invest. 109 2002 1429 1436
    • (2002) J. Clin. Invest. , vol.109 , pp. 1429-1436
    • Shuto, Y.1    Shibasaki, T.2    Otagiri, A.3    Kuriyama, H.4    Ohata, H.5    Tamura, H.6
  • 31
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, and K. Takaya Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 50 2001 227 232
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6
  • 33
    • 0034522843 scopus 로고    scopus 로고
    • Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    • J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and I. Wakabayashi Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression Endocrinology 141 2000 4797 4800
    • (2000) Endocrinology , vol.141 , pp. 4797-4800
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 37
    • 0036150931 scopus 로고    scopus 로고
    • GH-releasing peptide-2 increases fat mass in mice lacking NPY: Indication for a crucial mediating role of hypothalamic agouti-related protein
    • M. Tschop, M.A. Statnick, T.M. Suter, and M.L. Heiman GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein Endocrinology 143 2002 558 568
    • (2002) Endocrinology , vol.143 , pp. 558-568
    • Tschop, M.1    Statnick, M.A.2    Suter, T.M.3    Heiman, M.L.4
  • 38
    • 0037320674 scopus 로고    scopus 로고
    • Agouti-related peptide, Y. neuropeptide, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    • L.M. Seoane, M. Lopez, S. Tovar, F.F. Casanueva, R. Senaris, and C. Dieguez Agouti-related peptide, Y. neuropeptide, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus Endocrinology 144 2003 544 551
    • (2003) Endocrinology , vol.144 , pp. 544-551
    • Seoane, L.M.1    Lopez, M.2    Tovar, S.3    Casanueva, F.F.4    Senaris, R.5    Dieguez, C.6
  • 41
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
    • A. Asakawa, A. Inui, T. Kaga, H. Yuzuriha, T. Nagata, and N. Ueno Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin Gastroenterology 120 2001 337 345
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Yuzuriha, H.4    Nagata, T.5    Ueno, N.6
  • 43
    • 18044383296 scopus 로고    scopus 로고
    • Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    • N. Nagaya, K. Miyatake, M. Uematsu, H. Oya, W. Shimizu, and H. Hosoda Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure J. Clin. Endocrinol. Metab. 86 2001 5854 5859
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5854-5859
    • Nagaya, N.1    Miyatake, K.2    Uematsu, M.3    Oya, H.4    Shimizu, W.5    Hosoda, H.6
  • 44
    • 0035940390 scopus 로고    scopus 로고
    • Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: Relationships between ghrelin and anabolic/catabolic factors
    • N. Nagaya, M. Uematsu, M. Kojima, Y. Date, M. Nakazato, and H. Okumura Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors Circulation 104 2001 2034 2038
    • (2001) Circulation , vol.104 , pp. 2034-2038
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Date, Y.4    Nakazato, M.5    Okumura, H.6
  • 45
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • N. Nagaya, M. Uematsu, M. Kojima, Y. Ikeda, F. Yoshihara, and W. Shimizu Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Ikeda, Y.4    Yoshihara, F.5    Shimizu, W.6
  • 48
    • 0036184544 scopus 로고    scopus 로고
    • Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats
    • V. Sibilia, F. Pagani, F. Guidobono, V. Locatelli, A. Torsello, and R. Deghenghi Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats Neuroendocrinology 75 2002 92 97
    • (2002) Neuroendocrinology , vol.75 , pp. 92-97
    • Sibilia, V.1    Pagani, F.2    Guidobono, F.3    Locatelli, V.4    Torsello, A.5    Deghenghi, R.6
  • 50
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • F. Broglio, E. Arvat, A. Benso, C. Gottero, G. Muccioli, and M. Papotti Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans J. Clin. Endocrinol. Metab. 86 2001 5083 5086
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3    Gottero, C.4    Muccioli, G.5    Papotti, M.6
  • 51
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Y. Date, M. Nakazato, S. Hashiguchi, K. Dezaki, M.S. Mondal, and H. Hosoda Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion Diabetes 51 2002 124 129
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3    Dezaki, K.4    Mondal, M.S.5    Hosoda, H.6
  • 54
  • 56
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 57
    • 0033805978 scopus 로고    scopus 로고
    • Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans
    • E. Arvat, L. Di Vito, F. Broglio, M. Papotti, G. Muccioli, and C. Dieguez Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans J. Endocrinol. Invest. 23 2000 493 495
    • (2000) J. Endocrinol. Invest. , vol.23 , pp. 493-495
    • Arvat, E.1    Di Vito, L.2    Broglio, F.3    Papotti, M.4    Muccioli, G.5    Dieguez, C.6
  • 58
    • 0036360192 scopus 로고    scopus 로고
    • Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans
    • F. Broglio, A. Benso, C. Gottero, F. Prodam, S. Grottoli, and F. Tassone Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans Clin. Endocrinol. 57 2002 265 271
    • (2002) Clin. Endocrinol. , vol.57 , pp. 265-271
    • Broglio, F.1    Benso, A.2    Gottero, C.3    Prodam, F.4    Grottoli, S.5    Tassone, F.6
  • 61
    • 13444265857 scopus 로고    scopus 로고
    • Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    • B. Otto, U. Cuntz, E. Fruehauf, R. Wawarta, C. Folwaczny, and R.L. Riepl Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa Eur. J. Endocrinol. 145 2001 669 673
    • (2001) Eur. J. Endocrinol. , vol.145 , pp. 669-673
    • Otto, B.1    Cuntz, U.2    Fruehauf, E.3    Wawarta, R.4    Folwaczny, C.5    Riepl, R.L.6
  • 62
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • B.E. Wisse, R.S. Frayo, M.W. Schwartz, and D.E. Cummings Reversal of cancer anorexia by blockade of central melanocortin receptors in rats Endocrinology 142 2001 3292 3301
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 65
    • 0034809159 scopus 로고    scopus 로고
    • Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    • K. Toshinai, M.S. Mondal, M. Nakazato, Y. Date, N. Murakami, and M. Kojima Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration Biochem. Biophys. Res. Commun. 281 2001 1220 1225
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 1220-1225
    • Toshinai, K.1    Mondal, M.S.2    Nakazato, M.3    Date, Y.4    Murakami, N.5    Kojima, M.6
  • 68
    • 0036371860 scopus 로고    scopus 로고
    • Neuropeptides and appetite control
    • J.P. Wilding Neuropeptides and appetite control Diabet. Med. 19 2002 619 627
    • (2002) Diabet. Med. , vol.19 , pp. 619-627
    • Wilding, J.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.