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Volumn 11, Issue 3, 2006, Pages 427-440

Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 7; CYCLIN D1; CYTARABINE; DINUCLEOSIDE PHOSPHATE; DOXORUBICIN; FLOXURIDINE; PHOSPHATE; PRODRUG; PROTEIN P21; PROTEIN P27; PROTEIN P53;

EID: 33646427699     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-4066-x     Document Type: Article
Times cited : (15)

References (35)
  • 1
    • 0016164836 scopus 로고
    • A model for the chemotherapy of acute leukemia with 1-beta-D- arabinofuranosylcytosine
    • Momparler RL. A model for the chemotherapy of acute leukemia with 1-beta-D- arabinofuranosylcytosine. Cancer Res 1974; 34(8): 1775-1787.
    • (1974) Cancer Res , vol.34 , Issue.8 , pp. 1775-1787
    • Momparler, R.L.1
  • 2
    • 0020082901 scopus 로고
    • A pilot study of high-dose 1-beta-D-arabinofuranosylcytosine for acute leukemia and refractory lymphoma: Clinical response and pharmacology
    • Early AP, Preisler HD, Slocum H, Rustum YM. A pilot study of high-dose 1-beta-D-arabinofuranosylcytosine for acute leukemia and refractory lymphoma: clinical response and pharmacology. Cancer Res 1982; 42(4): 1587-94.
    • (1982) Cancer Res , vol.42 , Issue.4 , pp. 1587-1594
    • Early, A.P.1    Preisler, H.D.2    Slocum, H.3    Rustum, Y.M.4
  • 3
    • 20344381786 scopus 로고    scopus 로고
    • Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells
    • Saiko P, Horvath Z, Illmer C, Madlener S, et al. Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells. Leuk Res 2005; 29(7): 785-791.
    • (2005) Leuk Res , vol.29 , Issue.7 , pp. 785-791
    • Saiko, P.1    Horvath, Z.2    Illmer, C.3    Madlener, S.4
  • 4
    • 0033050165 scopus 로고    scopus 로고
    • Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer
    • Blum JL, Jones SE, Buzdar AU, et al. Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer. J Clin Oncol 1999; 17(2): 485-493.
    • (1999) J Clin Oncol , vol.17 , Issue.2 , pp. 485-493
    • Blum, J.L.1    Jones, S.E.2    Buzdar, A.U.3
  • 5
    • 18444417397 scopus 로고    scopus 로고
    • Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines
    • Talbot DC, Moiseyenko V, Van Belle S, et al. Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines. Br J Cancer 2002; 86(9): 1367-1372.
    • (2002) Br J Cancer , vol.86 , Issue.9 , pp. 1367-1372
    • Talbot, D.C.1    Moiseyenko, V.2    Van Belle, S.3
  • 6
    • 0034778024 scopus 로고    scopus 로고
    • Randomized, open-label, phase II trial of oral capecitabine (Xeloda) vs. a reference arm of intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) as first-line therapy for advanced/metastatic breast cancer
    • Oshaughnessy JA, Blum J, Moiseyenko V, et al. Randomized, open-label, phase II trial of oral capecitabine (Xeloda) vs. a reference arm of intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) as first-line therapy for advanced/metastatic breast cancer. Ann Oncol 2001; 12(9): 1247-1254.
    • (2001) Ann Oncol , vol.12 , Issue.9 , pp. 1247-1254
    • Oshaughnessy, J.A.1    Blum, J.2    Moiseyenko, V.3
  • 7
    • 16244398779 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5 -fluorodeoxyuridine and arabinofuranosylcytosine
    • Saiko P, Horvath Z, Bauer W, et al. In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5 -fluorodeoxyuridine and arabinofuranosylcytosine. Int J Oncol 2004; 25(2): 357-364.
    • (2004) Int J Oncol , vol.25 , Issue.2 , pp. 357-364
    • Saiko, P.1    Horvath, Z.2    Bauer, W.3
  • 8
    • 0035184489 scopus 로고    scopus 로고
    • Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance
    • Agarwal RP, Han T, Fernandez M. Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance. Biochem Pharmacol 2001; 61(1): 39-47.
    • (2001) Biochem Pharmacol , vol.61 , Issue.1 , pp. 39-47
    • Agarwal, R.P.1    Han, T.2    Fernandez, M.3
  • 9
    • 0021719254 scopus 로고
    • Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine
    • Bhalla K, Nayak R, Grant S. Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine. Cancer Res 1984; 44(11): 5029-5037.
    • (1984) Cancer Res , vol.44 , Issue.11 , pp. 5029-5037
    • Bhalla, K.1    Nayak, R.2    Grant, S.3
  • 10
    • 0017369396 scopus 로고
    • Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells
    • Wilkinson DS, Crumley J. Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells. J Biol Chem 1977; 252(3): 1051-1056.
    • (1977) J Biol Chem , vol.252 , Issue.3 , pp. 1051-1056
    • Wilkinson, D.S.1    Crumley, J.2
  • 11
    • 0033844236 scopus 로고    scopus 로고
    • The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145
    • Cattaneo-Pangrazzi RM, Schott H, Schwendener RA. The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145. Prostate 2000; 45(1): 8-18.
    • (2000) Prostate , vol.45 , Issue.1 , pp. 8-18
    • Cattaneo-Pangrazzi, R.M.1    Schott, H.2    Schwendener, R.A.3
  • 12
    • 0021870861 scopus 로고
    • Overproduction of p53 antigen makes established cells highly tumorigenic
    • Eliyahu D, Michalovitz D, Oren M. Overproduction of p53 antigen makes established cells highly tumorigenic. Nature 1985; 316(6024): 158-160.
    • (1985) Nature , vol.316 , Issue.6024 , pp. 158-160
    • Eliyahu, D.1    Michalovitz, D.2    Oren, M.3
  • 13
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz D, Halevy O, Oren M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 1990; 62(4): 671-680.
    • (1990) Cell , vol.62 , Issue.4 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 14
    • 0021272340 scopus 로고
    • Current NCI preclinical antitumor screening in vivo: Results of tumor panel screening, 1976-1982, and future directions
    • Venditti JM, Wesley RA, Plowman J. Current NCI preclinical antitumor screening in vivo: results of tumor panel screening, 1976-1982, and future directions. Adv Pharmacol Chemother 1984; 20: 1-20.
    • (1984) Adv Pharmacol Chemother , vol.20 , pp. 1-20
    • Venditti, J.M.1    Wesley, R.A.2    Plowman, J.3
  • 15
    • 0031035181 scopus 로고    scopus 로고
    • An information-intensive approach to the molecular pharmacology of cancer
    • Weinstein JN, Myers TG, O'Connor PM, et al. An information-intensive approach to the molecular pharmacology of cancer. Science 1997; 275(5298): 343-349.
    • (1997) Science , vol.275 , Issue.5298 , pp. 343-349
    • Weinstein, J.N.1    Myers, T.G.2    O'Connor, P.M.3
  • 16
    • 0029119742 scopus 로고
    • Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells
    • Gudas J, Nguyen H, Li T, Hill D, Cowan KH. Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells. Oncogene 1995; 11(2): 253-261.
    • (1995) Oncogene , vol.11 , Issue.2 , pp. 253-261
    • Gudas, J.1    Nguyen, H.2    Li, T.3    Hill, D.4    Cowan, K.H.5
  • 17
    • 0031890636 scopus 로고    scopus 로고
    • Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma
    • Suzuki A, Toi M, Yamamoto Y, Saji S, Muta M, Tominaga T. Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma. Jpn J Cancer Res 1998; 89(2): 221-227.
    • (1998) Jpn J Cancer Res , vol.89 , Issue.2 , pp. 221-227
    • Suzuki, A.1    Toi, M.2    Yamamoto, Y.3    Saji, S.4    Muta, M.5    Tominaga, T.6
  • 18
    • 0032580310 scopus 로고    scopus 로고
    • Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents
    • Andres JL, Fan S, Turkel GJ, et al. Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents. Oncogene 1998; 16(17): 2229-2241.
    • (1998) Oncogene , vol.16 , Issue.17 , pp. 2229-2241
    • Andres, J.L.1    Fan, S.2    Turkel, G.J.3
  • 19
    • 0033368192 scopus 로고    scopus 로고
    • De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line
    • Asada N, Tsuchiya H, Tomita K. De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. Anticancer Res 1999; 19(6B): 5131-5137.
    • (1999) Anticancer Res , vol.19 , Issue.6 B , pp. 5131-5137
    • Asada, N.1    Tsuchiya, H.2    Tomita, K.3
  • 20
    • 0037181478 scopus 로고    scopus 로고
    • Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepme, PBOX-6
    • Mc Gee MM, Hyland E, Campiani G, Ramunno A, Nacci V, Zisterer DM. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepme, PBOX-6. FEBS Lett 2002; 515(1-3): 66-70.
    • (2002) FEBS Lett , vol.515 , Issue.1-3 , pp. 66-70
    • Mc Gee, M.M.1    Hyland, E.2    Campiani, G.3    Ramunno, A.4    Nacci, V.5    Zisterer, D.M.6
  • 21
    • 0035839144 scopus 로고    scopus 로고
    • Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells
    • Hu CC, Tang CH, Wang JJ. Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells. FEBS Lett 2001; 503(1): 65-68.
    • (2001) FEBS Lett , vol.503 , Issue.1 , pp. 65-68
    • Hu, C.C.1    Tang, C.H.2    Wang, J.J.3
  • 22
    • 0034692451 scopus 로고    scopus 로고
    • Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53
    • Pirnia F, Breuleux M, Schneider E, et al. Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53. J Natl Cancer Inst 2000; 92(18): 1535-1536.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.18 , pp. 1535-1536
    • Pirnia, F.1    Breuleux, M.2    Schneider, E.3
  • 23
    • 0035798476 scopus 로고    scopus 로고
    • Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells
    • Liu XM, Wang LG, Kreis W, Budman DR, Adams LM. Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells. Br J Cancer 2001; 85(9): 1403-1411.
    • (2001) Br J Cancer , vol.85 , Issue.9 , pp. 1403-1411
    • Liu, X.M.1    Wang, L.G.2    Kreis, W.3    Budman, D.R.4    Adams, L.M.5
  • 24
    • 0033214624 scopus 로고    scopus 로고
    • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7
    • Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem 1999; 274(40): 28379-28384.
    • (1999) J Biol Chem , vol.274 , Issue.40 , pp. 28379-28384
    • Germain, M.1    Affar, E.B.2    D'Amours, D.3    Dixit, V.M.4    Salvesen, G.S.5    Poirier, G.G.6
  • 25
    • 0032546795 scopus 로고    scopus 로고
    • Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
    • Janicke RU, Ng P, Sprengart ML, Porter AG. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 1998; 273(25): 15540-15545.
    • (1998) J Biol Chem , vol.273 , Issue.25 , pp. 15540-15545
    • Janicke, R.U.1    Ng, P.2    Sprengart, M.L.3    Porter, A.G.4
  • 26
    • 0034117177 scopus 로고    scopus 로고
    • Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis
    • Daugas E, Susin SA, Zamzami N, et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. Faseb J 2000; 14(5): 729-739.
    • (2000) Faseb J , vol.14 , Issue.5 , pp. 729-739
    • Daugas, E.1    Susin, S.A.2    Zamzami, N.3
  • 27
    • 0027487005 scopus 로고
    • Synergistic action of tiazofurin with hypoxanthine and allopurinol in human neuroectodermal tumor cell lines
    • Szekeres T, Schuchter K, Chiba P, et al. Synergistic action of tiazofurin with hypoxanthine and allopurinol in human neuroectodermal tumor cell lines. Biochem Pharmacol 1993; 46(11): 1903-1907.
    • (1993) Biochem Pharmacol , vol.46 , Issue.11 , pp. 1903-1907
    • Szekeres, T.1    Schuchter, K.2    Chiba, P.3
  • 28
    • 0017620772 scopus 로고
    • The mechanism of action of inhibitors of DNA synthesis
    • Cozzarelli NR. The mechanism of action of inhibitors of DNA synthesis. Annu Rev Biochem 1977; 46: 641-668.
    • (1977) Annu Rev Biochem , vol.46 , pp. 641-668
    • Cozzarelli, N.R.1
  • 29
    • 1242286151 scopus 로고    scopus 로고
    • Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines
    • Bergman AM, Kuiper CM, Voorn DA, et al. Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines. Biochem Pharmacol 2004; 67(3): 503-511.
    • (2004) Biochem Pharmacol , vol.67 , Issue.3 , pp. 503-511
    • Bergman, A.M.1    Kuiper, C.M.2    Voorn, D.A.3
  • 30
    • 0020694938 scopus 로고
    • Effects of 5-fluoro-2′-deoxyuridine on DNA metabolism in HeLa cells
    • Cheng YC, Nakayama K. Effects of 5-fluoro-2′-deoxyuridine on DNA metabolism in HeLa cells. Mol Pharmacol 1983; 23(1): 171-174.
    • (1983) Mol Pharmacol , vol.23 , Issue.1 , pp. 171-174
    • Cheng, Y.C.1    Nakayama, K.2
  • 31
    • 0014341101 scopus 로고
    • Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5′-triphosphate of 9-beta-d-arabinofuranoxyladenine
    • Furth JJ, Cohen SS. Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5′-triphosphate of 9-beta-d-arabinofuranoxyladenine. Cancer Res 1968; 28(10): 2061-2067.
    • (1968) Cancer Res , vol.28 , Issue.10 , pp. 2061-2067
    • Furth, J.J.1    Cohen, S.S.2
  • 32
    • 0019131198 scopus 로고
    • Correlation of cytotoxicity with incorporation of ara-C into DNA
    • Kufe DW, Major PP, Egan EM, Beardsley GP. Correlation of cytotoxicity with incorporation of ara-C into DNA. J Biol Chem 1980; 255(19): 8997-9000.
    • (1980) J Biol Chem , vol.255 , Issue.19 , pp. 8997-9000
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3    Beardsley, G.P.4
  • 33
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-fluorouracil
    • Parker WB, Cheng YC. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther 1990; 48(3): 381-395.
    • (1990) Pharmacol Ther , vol.48 , Issue.3 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 34
    • 0032006318 scopus 로고    scopus 로고
    • Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer
    • van Laar JA, Rustum YM, Ackland SP, van Groeningen CJ, Peters GJ. Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer. Eur J Cancer 1998; 34(3): 296-306.
    • (1998) Eur J Cancer , vol.34 , Issue.3 , pp. 296-306
    • Van Laar, J.A.1    Rustum, Y.M.2    Ackland, S.P.3    Van Groeningen, C.J.4    Peters, G.J.5
  • 35
    • 0038392581 scopus 로고    scopus 로고
    • Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic lidamycin toward human tumor cells
    • Wang Z, He Q, Liang Y, Wang D, Li Y, Li D. Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic lidamycin toward human tumor cells. Biochem Pharmacol 2003; 65: 1767-1775.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1767-1775
    • Wang, Z.1    He, Q.2    Liang, Y.3    Wang, D.4    Li, Y.5    Li, D.6


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