The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145

Prostate

Volumn 45, Issue 1, 2000, Pages 8-18

  Cattaneo Pangrazzi, R M C ^a   Schott, H ^b   Schwendener, R A ^a,c  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

5 fluorodeoxyuridine; Apoptosis; Cytotoxicity; Dimeric prodrug; Thymidylate synthase

Indexed keywords

2' DEOXY 5 FLUOROURIDYLYL (5'-5') N OCTADECYL 1 BETA DEXTRO ARABINOFURANOSYLCYTOSINE; ANTINEOPLASTIC AGENT; CYTARABINE DERIVATIVE; CYTOTOXIC AGENT; DIMER; DINUCLEOSIDE PHOSPHATE; FLOXURIDINE; N OCTADECYL 1 BETA DEXTRO ARABINOFURANOSYLCYTOSINE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN; CHEMICAL BOND; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER;

ANDROGENS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BIOTRANSFORMATION; CELL CYCLE; CELL DIVISION; CYTARABINE; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOXURIDINE; FLUORODEOXYURIDYLATE; HUMANS; HYDROLYSIS; MALE; NEOPLASMS, HORMONE-DEPENDENT; PHOSPHODIESTERASE I; PHOSPHORIC DIESTER HYDROLASES; PRODRUGS; PROSTATIC NEOPLASMS; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033844236     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0045(20000915)45:1<8::AID-PROS2>3.0.CO;2-L     Document Type: Article

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