Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells

British Journal of Cancer

Volumn 85, Issue 9, 2001, Pages 1403-1411

  Liu, X M ^a   Wang, L G ^a   Kreis, W ^a   Budman, D R ^a   Adams, L M ^b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Apoptosis; bcl 2 phosphorylation; ERK2; MAP kinase; Poly (ADP) ribose polymerase; Vinorelbine

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA ACTIN; CASPASE; CASPASE 7; CELL DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NAVELBINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; RAF PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; PACLITAXEL; POLY(ADP-RIBOSE) POLYMERASES; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0035798476     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2107     Document Type: Article

References (45)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and vivo
2. 2-Methoxyestradiol-induced phosphorylation of bcl-2: Uncoupling from JNK/SAPK activation
3. Raf meets Ras: Completing the framework of a signal transduction pathway
4. Microtubule-damaging drugs triggered bcl-2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl-2 protein
5. Taxol induction of p21WAF1 and p53 requires c-raf-1
6. Taxol-induced apoptosis and phosphorylation of bcl-2 protein involves c-raf-1 and represents a novel c-raf-1 signal transduction pathway
7. Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
8. Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells
9. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
10. Bik, a novel death-inducing protein shares a distinct sequence motif with bcl-2 family proteins and interacts with viral and cellular survival promoting proteins
11. Vinorelbine (Navelbine): A third-generation vinca alkaloid
12. Synergism of cytotoxic effects of vinorelbine and paclitaxel in vitro
13. Activation of p34cdc2 coincident with taxol-induced apoptosis
14. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7
15. Inactivation of bcl-2 by phosphorylation
16. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
17. Bcl-2 is the guardian of microtubule integrity
18. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
19. Celegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
20. Microtubule organization and dynamics dependent on microtubule-associated proteins
21. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
22. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
23. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
24. Role of mitogen-activated protein kinase in taxol-induced apoptosis in human leukemic U937 cells
25. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
26. Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel
27. Checkpoints of dueling dimers foil death wishes
28. Signaling network of paclitaxel-induced apoptosis in the LNCaP prostate cancer cell line
29. Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines
30. Microtubule-associated protein auto-phosphorylation alters in vitro microtubule dynamic instability
31. Bcl-2 and the regulation of programmed cell death
32. The toxic responses induced by okadaic acid involve processing of multiple caspase isoforms
33. Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5″triphosphate pools in DNA damaged cells: Mechanism of stimulation of unscheduled DNA synthesis
34. Activation of casein kinase II in response to insulin and to epidermal growth factor
35. Involvement of microtubules in the regulation of bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
36. Yama/CPP32b, a mammalian homolog of CED-3, is a crm-A-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
37. Differential binding of nuclear c-ets-1 protein to an intron I fragment of the c-myb gene in growth versus differentiation
38. Activation of casein kinase II in ML-1 human myeloblastic leukemia cells requires IGF-1 and transferrin
39. Involvement of prostate-specific antigen in the stimulation of LNCaP cell growth
40. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
41. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signaling pathways on cell survival
42. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
43. Synergistic effect of Estramustine and PSC 833 on the inhibition of androgen receptor phosphorylation
44. Life, death and the pursuit of apoptosis
45. Bcl-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2/M