TGF-β1 stimulates IL-8 release, COX-2 expression, and PGE2 release in human airway smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 1 23-1, 2000, Pages

  Fong, Choong Yi ^a   Pang, Linhua ^a   Holland, Elaine ^a   Knox, Alan J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Airway inflammation; Asthma; Cytokines; Interleukin 8; Prostaglandin E2; Transforming growth factor 1

Indexed keywords

CYCLOOXYGENASE 2; DACTINOMYCIN; DEXAMETHASONE; INDOMETACIN; INTERLEUKIN 8; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA1; CYCLOOXYGENASE 2 INHIBITOR; GLUCOCORTICOID; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN SYNTHESIS INHIBITOR; PTGS2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

AGED; ARTICLE; ASTHMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; SMOOTH MUSCLE; TIME; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY; TRACHEA;

AGED; AGED, 80 AND OVER; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DACTINOMYCIN; DEXAMETHASONE; DINOPROSTONE; ENZYME INDUCTION; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-8; ISOENZYMES; MALE; MEMBRANE PROTEINS; MUSCLE, SMOOTH; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN SYNTHESIS INHIBITORS; TRACHEA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0001760198     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.1.l201     Document Type: Article

References (38)

1. Appelby SB, Ristimaki A, Neilson K, Narko K, and Hla T. Structure of the human cyclo-oxygenase-2 gene. Biochem J 302: 723-727, 1994.
2. Arici A, McDonald PC, and Casey ML. Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1. J Clin Endocrinol Metab 81: 3004-3009, 1996.
3. Belvisi MG, Saunders MA, Haddad EB, Hirst SJ, Yacoub MH, and Mitchell JA. Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br J Pharmacol 120: 910-916, 1997.
4. Black PN, Young PG, and Stephen JMS. Response of airway smooth muscle cells to TGF-β1: effect on growth and synthesis of glycosaminoglycans. Am J Physiol Lung Cell Mol Physiol 271: L910-L917, 1996.
5. Border WA and Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994.
6. Folkard SG, Westwick J, and Millar AB. Production of interleukin-8, RANTES, and MCP-1 in intrinsic and extrinsic asthmatics. Eur Respir J 10: 2097-2104, 1997.
7. Gerritsma JS, van Kooten C, Gerritsen AF, van Es LA, and Daha MR. Transforming growth factor-beta 1 regulates chemokine and complement production by human proximal tubular epithelial cells. Kidney Int 53: 609-616, 1998.
8. Hoshino M, Nakamura Y, and Sim JJ. Expression of growth factors and remodeling of the airway wall in bronchial asthma. Thorax 53: 21-27, 1998.
9. 2 in lung fibroblasts and endothelial cells in culture. Biochem Biophys Res Commun 197: 1465-1474, 1993.
10. John M, Hirst SJ, Jose PJ, Robichaud A, Berkman N, Witt C, Twort CHC, Barnes PJ, and Chung KF. Human airway smooth muscle cells express and release RANTES in response to TH1 cytokines: regulation by TH2 cytokines and corticosteroids. J Immunol 158: 1841-1847, 1997.
11. Johnson SR and Knox AJ. Synthetic functions of airway smooth muscle in asthma. Trends Pharmacol Sci 18: 288-292, 1997.
12. Knox AJ and Tattersfield AE. Airway smooth muscle relaxation. Thorax 50: 894-901, 1995.
13. Lee TH. Cytokine networks in the pathogenesis of bronchial asthma: implications for therapy. J R Coll Physicians Lond 32: 56-64, 1998.
14. Levine JS. Bronchial epithelial cell-cytokine interactions in airway inflammation. J Investig Med 43: 241-249, 1995.
15. Luo J, Lang JA, and Miller MW. Transforming growth factor β1 regulates the expression of cyclooxygenase in cultured cortical astrocytes and neurons. J Neurochem 71: 526-534, 1998.
16. Magnan A, Frochol I, Rain B, Peuchmaur M, Monti G, Lenot B, Fattal M, Simonneau G, Galanaud P, and Emilie D. Transforming growth factor β in normal human lung: preferential location in bronchial epithelial cells. Thorax 49: 789-792, 1994.
17. Marini M, Vittori E, Hollemborg J, and Mattoli S. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8 in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol 89: 1001-1009, 1992.
18. Mitchell JA, Larkin S, and Williams TJ. Cyclooxygenase-2 regulation and relevance in inflammation. Biochem Pharmacol 50: 1535-1542, 1995.
19. Ohno I, Nitta Y, Yamauchi K, Hoshi H, Honma M, Wooley K, O'Bryne P, Tamura G, Jordana M, and Shirato K. Transforming growth factor β1 (TGFβ1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 15: 404-409, 1996.
20. Pang L, Holland E, and Knox AJ. Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products. Am J Physiol Lung Cell Mol Physiol 275: L322-L329, 1998.
21. Pang L, Holland E, and Knox AJ. Role of cyclo-oxygenase-2 induction in interleukin-1β induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline. Br J Pharmacol 125: 1320-1328, 1998.
22. Pang L and Knox AJ. Effect of interleukin-1β, tumour necrosis factor-α and interferon-γ on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. Br J Pharmacol 121: 579-587, 1997.
23. 2 release by bradykinin in human airway smooth muscle cells: involvement of cyclooxygenase-2 induction. Am J Physiol Lung Cell Mol Physiol 273: L1132-L1140, 1997.
24. Pang L and Knox AJ. Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products. J Immunol 161: 2509-2515, 1998.
25. Pang L and Knox AJ. Effect of β-adrenoceptor agonists and dexamethasone on IL-8 production in human airway smooth muscle cells (Abstract). Thorax 53: A21, 1998.
26. Pang L, Pitt A, Petkova D, and Knox AJ. The COX-1/COX-2 balance in asthma. Clin Exp Allergy 28: 1050-1058, 1998.
27. 2. Lancet 345: 436-438, 1995.
28. Pelton RW, Johnson MD, Perkett EA, Gold LI, and Moses HL. Expression of TGFβ1, β2, and β3 mRNA and protein in the murine lung. Am J Respir Cell Mol Biol 5: 522-530, 1991.
29. Perkett EA. Role of growth factors in lung repair and diseases. Curr Opin Pediatr 7: 242-249, 1995.
30. Poston RN, Chanez P, Litchfield T, Lee TH, and Bousquet J. Immunohistochemical characterization of the cellular infiltration in asthmatic bronchi. Am Rev Respir Dis 145: 918-921, 1992.
31. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, and Howarth PH. Transforming growth factor-β1 in asthma: measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 156: 642-647, 1997.
32. Saunders MA, Mitchell JA, Seldon PM, Yacoub MH, Barnes PJ, Giembycz MA, and Belvisi MG. Release of granulocyte-macrophage-colony-stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone. Br J Pharmacol 120: 545-546, 1997.
33. Shute JK, Vrugt B, Lindley IJD, Holgate ST, Bron A, Aalbers R, and Djukanovic R. Free and complexed interleukin-8 in blood and bronchial mucosa in asthma. Am J Respir Crit Care Med 155: 1877-1863, 1997.
34. SPSS Inc. SPSS Base for Windows User's Guide. Chicago, IL: SPSS, 1996.
35. Vignola AM, Chanez P, Chiappara G, Merendino AM, La Rocca AM, Bellia V, Bousquet J, and Bonsignore G. TGF-β and EGF in asthma and chronic bronchitis (Abstract). Am J Respir Crit Care Med 151: A703, 1995.
36. Wahl SM. Transforming growth factor-beta (TGF-β) in inflammation: a cause and a cure. J Clin Immunol 12: 61-74, 1992.
37. Walker C, Bauer W, Braun RK, Menz G, Braun P, Schwarz F, Hansel TT, and Villiger B. Activated T-cells and cytokines in bronchoalveolar lavage from patients with various lung disorders associated with eosinophilia. Am J Respir Crit Care Med 150: 1038-1048, 1994.
38. Yang XF, Hou FX, Taylor L, and Polgar P. Characterization of human cyclooxygenase 2 gene promoter localization of the TGF-β response element. Biochim Biophys Acta 1350: 287-292, 1997.