Calcium and calmodulin are essential for Ras-GRF1-mediated activation of the Ras pathway by lysophosphatidic acid

Experimental Cell Research

Volumn 258, Issue 2, 2000, Pages 403-408

  Zippel, Renata ^a   Balestrini, Monica ^a   Lomazzi, Marina ^a   Sturani, Emmapaola ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Calcium; Calmodulin; CDC25Mm; LPA; MAPK; Ras; Ras GRF

Indexed keywords

CALCIUM; CALMODULIN; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034256010     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4937     Document Type: Article

References (31)

1. Martegani E., Vanoni M., Zippel R., Coccetti P., Brambilla R., Ferrari C., Sturani E., Alberghina L. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J. 11:1997;2151-2157.
2. Shou C., Farnsworth C. L., Neel B. G., Feig L. A. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature. 358:1992;351-354.
3. Zippel R., Gnesutta N., Matus-Leibovich N., Mancinelli E., Saya D., Vogel Z., Sturani E. Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system. Mol. Brain Res. 48:1997;140-144.
4. Brambilla R., Gnesutta N., Minichiello L., White G., Roylance A. J., Herron C. E., Ramsey M., Wolfer D. P., Cestari V., Rossi-Arnaud C., Grant S. G. N., Chapman P. F., Lipp H.-P., Sturani E., Klein R. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature. 390:1997;281-286.
5. Farnsworth C. L., Freshney N. W., Rosen L. B., Ghosh A., Greenberg M. E., Feig L. A. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature. 376:1995;524-526.
6. Mattingly R. R., Macara I. G. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature. 382:1996;268-272.
7. Zippel R., Orecchia S., Sturani E., Martegani E. The brain specific Ras exchange factor CDC25 Mm: Modulation of its activity through Gi-protein-mediated signals. Oncogene. 12:1996;2697-2703.
8. Mattingly R. R., Saini V., Macara I. G. Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid. Cell. Signalling. 11:1999;603-610.
9. Buchsbaum R., Telliez J. B., Goonesekera S., Feig L. A. The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium. Mol. Cell. Biol. 16:1996;4888-4896.
10. Anborgh P. H., Qian X. L., Papageorge A. G., Vass W. C., DeClue J. E., Lowy D. R. Ras-specific exchange factor GRF: Oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol. Cell. Biol. 19:1999;4611-4622.
11. Freshney N. W., Goonesekera S. D., Feig L. A. Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain. FEBS Lett. 407:1997;111-115.
12. Mm/Ras-GRF1 regulates both Ras and Rac signalling pathways. FEBS Lett. 460:1999;357-362.
13. Taylor S. J., Shalloway D. Cell cycle-dependent activation of Ras. Curr. Biol. 6:1996;1621-1627.
14. Tonini R., Mancinelli E., Balestrini M., Mazzanti M., Martegani E., Ferroni A., Sturani E., Zippel R. Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel. Eur. J. Neurosci. 11:1999;959-966.
15. Crespo P., Xu N., Simonds W. F., Gutkind J. S. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature. 369:1994;418-420.
16. Meloche S., Pages G., Pouyssegur J. Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. Mol. Biol. Cell. 3:1992;63-71.
17. 2+/CaM kinase. Cell Growth Differ. 6:1995;1063-1070.
18. Sturani E., Abbondio A., Branduardi P., Ferrari C., Zippel R., Martegani E., Vanoni M., Donini S. D. The Ras guanine nucleotide exchange factor CDC25Mm is present at the synaptic junction. Exp. Cell Res. 235:1997;117-123.
19. Fitzgerald E. M., Dolphin A. C. Regulation of rat neuronal voltage-dependent calcium channels by endogenous p21-ras. Eur. J. Neurosci. 9:1997;1251-1261.
20. Hille B. Ionic Channels of Excitable Membranes. 1992;Sinauer, Sunderland.
21. An S., Goetzl E. J., Lee H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell. Biochem. 30:1998;147-157.
22. An S., Bleu T., Zheng Y., Goetzl E. J. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol. Pharmacol. 54:1998;881-888.
23. Della Rocca G. J., van Biesen T., Daaka Y., Luttrell D. K., Luttrell L. M., Lefkowitz R. J. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J. Biol. Chem. 272:1997;19125-19132.
24. Hordijk P. L., Verlaan I., van Corven E. J., Moolenaar W. H. Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21 ras pathway. J. Biol. Chem. 269:1994;645-651.
25. Clapham D. E. Calcium signaling. Cell. 80:1995;259-268.
26. Kiyono M., Satoh T., Kaziro Y. G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). Proc. Natl. Acad. Sci. USA. 96:1999;4826-4831.
27. Touhara K., Inglese J., Pitcher J. A., Shaw G., Lefkowitz R. J. Binding of G protein beta gamma-subunits to pleckstrin homology domains. J. Biol. Chem. 269:1994;10217-10220.
28. Baouz S., Jacquet E., Bernardi A., Parmeggiani A. The N-terminal moiety of CDC25(Mm), a GDP/GTP exchange factor of Ras proteins, controls the activity of the catalytic domain. Modulation by calmodulin and calpain. J. Biol. Chem. 272:1997;6671-6676.
29. English J. D., Sweatt J. D. Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J. Biol. Chem. 271:1996;24329-24332.
30. Ambrosini A., Tininini S., Barassi A., Racagni G., Sturani E., Zippel R. cAMP cascade leads to Ras activation in cortical neurons. Mol. Brain Res. 75:2000;54-60.
31. Deisseroth K., Bito H., Tsien R. W. Signaling from synapse to nucleus: Postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 16:1996;89-101.