Reversal of the malignant phenotype of cervical cancer CaSki cells through adeno-associated virus - Mediated delivery of HPV16 E7 antisense RNA

Clinical Cancer Research

Volumn 12, Issue 7 I, 2006, Pages 2032-2037

  Wu, Sufang ^a,b   Meng, Li ^a   Wang, Shixuan ^a   Wang, Wei ^a   Xi, Ling ^a   Tian, Xun ^a   Chen, Gang ^a   Wu, Ying ^a   Zhou, Jianfeng ^a   Xu, Gang ^a   Lu, Yunping ^a   Ma, Ding ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY RNA; PROTEIN E7;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; FEMALE; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; UTERINE CERVIX CANCER; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; APOPTOSIS; CARCINOGENICITY TESTS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS, VIRAL; PHENOTYPE; RECOMBINANT PROTEINS; RNA, ANTISENSE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 33646240852     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-2567     Document Type: Article

References (48)

1. Anderson WF. Human gene therapy. Nature 1998; 392:25-30.
2. Fox JL. NIHRAC: disguised retirement or vigorous future? Nat Biotechnol 1997;15:11-2.
3. Vile RG, Tuszynski A, Castleden S. Retroviral vectors. From laboratory tools to molecular medicine. Mol Biotechnol 1996;5:139-58.
4. Kremer EJ, Perricaudet M. Adenovirus and adeno-associated virus mediated gene transfer. Br Med Bull 1995;51:31-44.
5. Liu DW, Tsao YP, Kung JT, et al. Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. J Virol 2000;74:2888-94.
6. Lee RJ, Huang L. Lipidic vector systems for gene transfer. Crit Rev Ther Drug Carrier Syst 1997;14:173-206.
7. Yonemitsu Y, Alton EW, Komori K, Yoshizumi T, Sugimachi K, Kaneda Y. HVJ (Sendai virus) liposome-mediated gene transfer: current status and future perspectives. Int J Oncol 1998;12:1277-85.
8. Yang NS, Sun WH. Gene gun and other non-viral approaches for cancer gene therapy. Nat Med 1995;1:481-3.
9. Schwartz B, Benoist C, Abdallah B, et al. Gene transfer by naked DNA into adult mouse brain. Gene Ther 1996;3:405-11.
10. Zoulim F, Trepo C. New antiviral agents for the therapy of chronic hepatitis B virus infection. Intervirology 1999;42:125-44.
11. Avgeropoulos NG, Batchelor TT. New treatment strategies for malignant gliomas. Oncologist 1999;4:209-24.
12. Pattillo RA, Hussa RO, Story MT, Ruckert AC, Shalaby MR, Mattingly RF. Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line. Science 1977;196:1456-8.
13. Schoell WM, Janicek MF, Mirhashemi R. Epidemiology and biology of cervical cancer. Semin Surg Oncol 1999;16:203-11.
14. Kiernan GN, Frame PS. Cancer occurrence and screening in family practice. A 20-year experience. J Fam Pract 1996;43:49-55.
15. Syrjanen KJ. Epidemiology of human papillomavirus (HPV) infections and their associations with genital squamous cell cancer. Review article. APMIS 1989;97:957-70.
16. Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst 1995;87:796-802.
17. Lungu O, Sun XW, Wright TC, Jr., Ferenczy A, Richart RM, Silverstein S. A polymerase chain reaction-enzyme-linked immunosorbent assay method for detecting human papillomavirus in cervical carcinomas and high-grade cervical cancer precursors. Obstet Gynecol 1995;85:337-42.
18. Qu W, Jiang G, Cruz Y, et al. PCR detection of human papillomavirus: comparison between MY09/ MY11 and GP51/GP61 primer systems. J Clin Microbiol 1997;35:1304-10.
19. Park JS, Hwang ES, Park SN, et al. Physical status and expression of HPV genes in cervical cancers. Gynecol Oncol 1997;65:121-9.
20. Choo CK, Ling MT, Chan KW, et al. Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames. Prostate 1999;40:150-8.
21. Kaur P, McDougall JK. HPV-18 immortalization of human keratinocytes. Virology 1989;173:302-10.
22. Pecoraro G, Morgan D, Defendi V. Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells. Proc Natl Acad Sci U S A 1989;86:563-7.
23. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
24. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993;75:495-505.
25. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 1989;8:4099-105.
26. Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 1996;56:4620-4.
27. Erbacher P, Bousser MT Raimond J, Monsigny M, Midoux P, Roche AC. Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages. Hum Gene Ther 1996;7:721-9.
28. Heck DV, Yee CL, Howley PM, Munger K. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc Natl Acad Sci U S A 1992;89:4442-6.
29. Schmitt A, Harry JB, Rapp B, Wettstein FO, Iftner T. Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1. J Virol 1994;68:7051-9.
30. Madrigal M, Janicek MF, Sevin BU, et al. In vitro antigene therapy targeting HPV-16 E6 and E7 in cervical carcinoma. Gynecol Oncol 1997;64:18-25.
31. Hamada K, Sakaue M, Alemany RZ. Adenovirus-mediated transfer of HPV16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol Oncol 1996;63:219-27.
32. Baker C, Calef C. Human papillomaviruses: a compilation and analysis of nucleic acid and amino acid sequences, p. III-3-III-19. [Online.] Los Alamos National Laboratory, Los Alamos, N.Mex. http://hpv-web.lanl.gov/stdgen/virus/hpv/compendium/htdocs/OMPENDIUM_PDF/95PDF/ 3/maps.pdf; 1995.
33. Hall AH, Alexander KA. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J Virol 2003;77:6066-9.
34. Xiao X, Li J, Samulski RJ. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol 1998;72:2224-32.
35. Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996;70:8098-108.
36. Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12.
37. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory; 1989.
38. Hauck CR, Sieg DJ, Hsia DA, et al. Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res 2001;61:7079-90.
39. Alvarez RD, Curiel DT. A Phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients. Hum Gene Ther 1997;8:597-613.
40. During MJ, Xu R, Young D, et al. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nat Med 1998;4:1131-5.
41. Tamada Y, Aoki D, Nozawa S, Irimura T. Model for paraaortic lymph node metastasis produced by orthotopic implantation of ovarian carcinoma cells in athymic nude mice. Eur J Cancer 2004;40:158-63.
42. Schwarz E, Freese UK, Gissmann L, et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985;24:314, 111-4.
43. Deshane J, Siegal GP, Wang M, et al. Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapy. Gynecol Oncol 1997;64:378-85.
44. Zur Hausen H. Papillomaviruses in human cancers. Proc Assoc Am Physicians 1999;111:581-7.
45. Howley PM, Scheffner M, Munger K. Oncoproteins encoded by the cancer-associated human papillomavirus target the products of the retinoblastoma and p53 tumor suppressor genes. Cold Spring Harbor Symp Quant Biol 1991;56:149-55.
46. Duensing S, Duensing A, Crum CP, Munger K. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res 2001;61:2356-60.
47. Kozuka T, Aoki Y, Nakagawa K, et al. Enhancer-promoter activity of human papillomavirus type 16 long control regions isolated from cell lines SiHa and CaSki and cervical cancer biopsies. Jpn J Cancer Res 2000;91:271-9.
48. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR, Schiller JT. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 1989;8:3905-10.