Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42

FASEB Journal

Volumn 20, Issue 6, 2006, Pages 683-691

  Blanke, Stephen ^a   Jäckle, Herbert ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

DH domain; DRal activity; Gastrulation

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN CDC42; RAL PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; CDC42 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; GEFMESO PROTEIN, DROSOPHILA; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENE MUTATION; GENE OVEREXPRESSION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; ANIMAL; CHEMISTRY; CHROMOSOME MAP; FORELIMB; GENE EXPRESSION REGULATION; METABOLISM; PRENATAL DEVELOPMENT;

DROSOPHILA MELANOGASTER;

ANIMALS; CHROMOSOME MAPPING; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; PROTEIN BINDING; RAL GTP-BINDING PROTEINS; WING;

EID: 33646237351     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5376com     Document Type: Article

References (42)

1. White, M. A., Vale, T., Camonis, J. H., Schaefer, E., and Wigler, M. H. (1996) A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J. Biol. Chem. 271, 16439-16442
2. Urano, T., Emkey, R., and Feig, L. A. (1996) Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J. 15, 810-816
3. Nakashima, S., Morinaka, K., Koyama, S., Ikeda, M., Kishida, M., Okawa, K., Iwamatsu, A., Kishida, S., and Kikuchi, A. (1999) Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 18, 3629-3642
4. Brymora, A., Valova, V. A., Larsen, M. R., Roufogalis, B. D., and Robinson, P. J. (2001) The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J. Biol. Chem. 276, 29792-29797
5. Moskalenko, S., Henry, D. O., Rosse, C., Mirey, G., Camonis, J. H., and White, M. A. (2002) The exocyst is a Ral effector complex. Nat. Cell Biol. 4, 66-72
6. Sugihara, K., Asano, S., Tanaka, K., Iwamatsu, A., Okawa, K., and Ohta, Y. (2002) The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat. Cell Biol. 4, 73-78
7. Polzin, A., Shipitsin, M., Goi, T., Feig, L. A., and Turner, T. J. (2002) Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Mol. Cell. Biol. 22, 1714-1722
8. Ohta, Y., Suzuki, N., Nakamura, S., Hartwig, J. H., and Stossel, T. P. (1999) The small GTPase RalA targets filamin to induce filopodia. Proc. Natl. Acad. Sci. USA 96, 2122-2128
9. Gildea, J. J., Harding, M. A., Seraj, M. J., Gulding, K. M., and Theodorescu, D. (2002) The role of Ral A in epidermal growth factor receptor-regulated cell motility. Cancer Res. 62, 982-985
10. Suzuki, J., Yamazaki, Y., Li, G., Kaziro, Y., and Koide, H. (2000) Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol. Cell. Biol. 20, 4658-4665
11. Emkey, R., Freedman, S., and Feig, L. A. (1991) Characterization of a GTPase-activating protein for the Ras-related Ral protein. J. Biol. Chem. 266, 9703-9706
12. Bhullar, R. P., and Seneviratne, H. D. (1996) Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein. Biochim. Biophys. Acta 1311, 181-188
13. Wolthuis, R. M., and Bos, J. L. (1999) Ras caught in another affair: the exchange factors for Ral. Curr. Opin. Genet. Dev. 9, 112-117
14. Gotoh, T., Cai, D., Tian, X., Feig, L. A., and Lerner, A. (2000) p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275, 30118-30123
15. Rebhun, J. F., Chen, H., and Quilliam, L. A. (2000) Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. J. Biol. Chem. 275, 13406-13410
16. Luo, J. Q., Liu, X., Hammond, S. M., Colley, W. C., Feig, L. A., Frohman, M. A., Morris, A. J., and Foster, D. A. (1997) RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem. Biophys. Res. Commun. 235, 854-859
17. Luo, J. Q., Liu, X., Frankel, P., Rotunda, T., Ramos, M., Flom, J., Jiang, H., Feig, L. A., Morris, A. J., Kahn, R. A., et al. (1998) Functional association between Arf and RalA in active phospholipase D complex. Proc. Natl. Acad. Sci. USA 95, 3632-3637
18. Jullien-Flores, V., Dorseuil, O., Romero, F., Letourneur, F., Saragosti, S., Berger, R., Tavitian, A., Gacon, G., and Camonis, J. H. (1995) Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J. Biol. Chem. 270, 22473-22477
19. Cantor, S. B., Urano, T., and Feig, L. A. (1995) Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol. Cell. Biol. 15, 4578-4584
20. Park, S. H., and Weinberg, R. A. (1995) A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene 11, 2349-2355
21. Frankel, P., Aronheim, A., Kavanagh, E., Balda, M. S., Matter, K., Bunney, T. D., and Marshall, C. J. (2005) RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity. EMBO J. 24, 54-62
22. Baron, M., O'Leary, V., Evans, D. A., Hicks, M., and Hudson, K. (2000) Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster. Mol. Gen. Genet. 264, 98-104
23. Genova, J. L., Jong, S., Camp, J. T., and Fehon, R. G. (2000) Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. Dev. Biol. 221, 181-194
24. Fields, S., and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature (London) 340, 245-246
25. Sawamoto, K., Winge, P., Koyama, S., Hirota, Y., Yamada, C., Miyao, S., Yoshikawa, S., Jin, M. H., Kikuchi, A., and Okano, H. (1999) The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. J. Cell Biol. 146, 361-372
26. Zhang, F. L., and Casey, P. J. (1996) Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65, 241-269
27. Brand, A. H., and Perrimon, N. (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415
28. FlyBase (1999) The FlyBase database of the Drosophila genome projects and community literature. http://flybase.bio.indiana.edu/. Nucleic Acids Res. 27, 85-88
29. Ridley, A. J. (2001) Rho GTPases and cell migration. J. Cell Sci. 114, 2713-2722
30. Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) The genome sequence of Drosophila melanogaster. Science 287, 2185-2195
31. Yaffe, M. B., Leparc, G. G., Lai, J., Obata, T., Volinia, S., and Cantley, L. C. (2001) A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19, 348-353
32. Zheng, Y. (2001) Dbl family guanine nucleotide exchange factors. Trends Biochem. Sci. 26, 724-732
33. Cerione, R. A., and Zheng, Y. (1996) The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8, 216-222
34. Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., and Sondek, J. (2002) A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315-1326
35. Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., and Sondek, J. (2002) Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat. Struct. Biol. 9, 468-475
36. Goldberg, J. (1998) Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell 95, 237-248
37. Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J. (1998) The structural basis of the activation of Ras by Sos. Nature (London) 394, 337-343
38. Zhu, K., Debreceni, B., Li, R., and Zheng, Y. (2000) Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation. J. Biol. Chem. 275, 25993-26001
39. Luo, L., Liao, Y. J., Jan, L. Y., and Jan, Y. N. (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787-1802
40. Kennerdell, J. R., and Carthew, R. W. (2000) Heritable gene silencing in Drosophila using double-stranded RNA. Nat. Biotechnol. 18, 896-898
41. Van Aelst, L., and D'Souza-Schorey, C. (1997) Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322
42. Mirey, G., Balakireva, M., L'Hoste, S., Rosse, C., Voegeling, S., and Camonis, J. (2003) A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol. Cell. Biol. 23, 1112-1124