RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA

RNA

Volumn 12, Issue 5, 2006, Pages 807-818

  Parker, Greg S ^a   Eckert, Debra M ^a   Bass, Brenda L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

C. elegans; Dicer; dsRNA; RNA interference

Indexed keywords

DOUBLE STRANDED RNA; HOMODIMER; PROTEIN; RDE 4 PROTEIN; RNA BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PURIFICATION; RNA CLEAVAGE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DEAD-BOX RNA HELICASES; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMBRYO, NONMAMMALIAN; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROTEIN STRUCTURE, TERTIARY; RNA HELICASES; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

ARABIDOPSIS; CAENORHABDITIS ELEGANS;

EID: 33646186518     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2338706     Document Type: Article

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