Corrigendum to "Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors" [Bioorg. Med. Chem. Lett. 14 (2004) 3109-3112] (DOI:10.1016/j.bmcl.2004.03.079);Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2715-2717

  Jeong, Tae Sook ^a   Kim, Kyung Soon ^a   An, So Jin ^a   Cho, Kyung Hyun ^a   Lee, Sangku ^a   Lee, Woo Song ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

ACAT inhibitor

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; PYRAZOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 2342647591     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.113     Document Type: Erratum

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12. 3) δ 30.2, 30.3, 34.37, 34.4, 42.2, 64.9, 123.1, 123.3, 124.4, 133.1, 136.0, 136.1, 152.6, 153.3, 154.7
13. 14C]oleoyl-CoA solution (0.05 μCi, final concn 10 μM). After 25 min of incubation at 37°C, the reaction was stopped by the addition of 1.0 mL of isopropanol-heptane (4:1; v/v) solution. A mixture of 0.6 mL of heptane and 0.4 mL of 0.1 M potassium-phosphate buffer (pH 7.4, 2 mM dithiothreitol) was then added to the terminated reaction mixture. The above solution was mixed and allowed to phase separation under gravity for 2 min. Cholesterol oleate was recovered in the upper heptane phase (total volume 0.9-1.0 mL). The radioactivity in 100 μL of the upper phase was measured in scintillation vial with 3 mL of scintillation cocktail (Lipoluma, Lumac Co.) using a liquid scintillation counter (1450 Microbeta Trilux Wallac Oy, Turku, Finland). Background values were obtained by preparing heat inactivated microsomes. The ACAT activity was expressed as a defined unit, cholesteryl oleate pmol/min/mg protein
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