Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences

Journal of Lipid Research

Volumn 42, Issue 8, 2001, Pages 1282-1291

  Guo, Zhongmin ^a,c   Cromley, Debra ^b   Billheimer, Jeffrey T ^b   Sturley, Stephen L ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b DUPONT COMPANY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

ACAT cholesterol; Steryl ester

Indexed keywords

CARBON 14; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; RECOMBINANT DNA;

ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; GENE EXPRESSION; HUMAN; MISSENSE MUTATION; MUTAGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; YEAST;

ACYLTRANSFERASES; ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; ESTERIFICATION; GENE DELETION; GENE EXPRESSION; HUMANS; LEUCINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROMOTER REGIONS (GENETICS); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRYPTOPHAN; TYROSINE;

EID: 0034879955     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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