메뉴 건너뛰기




Volumn 2, Issue 1, 2005, Pages 28-38

Trick or treat: The effect of placebo on the power of pharmacogenetic association studies

Author keywords

Haplotype; Power; Simulation; Single nucleotide polymorphism; Trial design

Indexed keywords

DRUG; PLACEBO;

EID: 33646176438     PISSN: 14797364     EISSN: 14797364     Source Type: Journal    
DOI: 10.1186/1479-7364-2-1-28     Document Type: Article
Times cited : (10)

References (33)
  • 1
    • 0034660560 scopus 로고    scopus 로고
    • Pharmacogenetics and the practice of medicine'
    • Roses, A.D. (2000), Pharmacogenetics and the practice of medicine', Nature Vol. 405, pp. 857-865.
    • (2000) Nature , vol.405 , pp. 857-865
    • Roses, A.D.1
  • 2
    • 0035369825 scopus 로고    scopus 로고
    • 'Genetic susceptibility to adverse drug reactions'
    • Pirmohamed, M. and Park, B.K. (2001), 'Genetic susceptibility to adverse drug reactions', Trends Pharmacol. Sci. Vol. 22, pp. 298-305.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 298-305
    • Pirmohamed, M.1    Park, B.K.2
  • 3
    • 0032151243 scopus 로고    scopus 로고
    • 'The effects ofthe genetic absence and inhibition of CYP2D6 on the metabolism of codeine and its derivatives hydrocodone and oxycodone'
    • Lurcott, G. (1998), 'The effects ofthe genetic absence and inhibition of CYP2D6 on the metabolism of codeine and its derivatives, hydrocodone and oxycodone', Anesth. Prog. Vol. 45, pp. 154-156.
    • (1998) Anesth. Prog. , vol.45 , pp. 154-156
    • Lurcott, G.1
  • 4
    • 0034612110 scopus 로고    scopus 로고
    • 'Pharmacogenetic prediction of clozapine response'
    • Arranz, M.J., Munro, J., Birkett, J. et al. (2000), 'Pharmacogenetic prediction of clozapine response', Lancet Vol. 355, pp. 1615-1616.
    • (2000) Lancet , vol.355 , pp. 1615-1616
    • Arranz, M.J.1    Munro, J.2    Birkett, J.3
  • 5
    • 0038579530 scopus 로고    scopus 로고
    • 'Effect of regression to the mean on decision making in health care'
    • Morton, V and Torgerson, D.J. (2003), 'Effect of regression to the mean on decision making in health care', BMJ. Vol. 326, pp. 1083-1084.
    • (2003) BMJ , vol.326 , pp. 1083-1084
    • Morton, V.1    Torgerson, D.J.2
  • 6
    • 0035950690 scopus 로고    scopus 로고
    • 'Is the placebo powerless?'
    • author reply pp. 1278-1279
    • Spiegel, D., Kraemer, H. and Carlson, R.W. (2001), 'Is the placebo powerless?', N. Engl. J. Med. Vol. 345, pp. 1276; author reply pp. 1278-1279.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1276
    • Spiegel, D.1    Kraemer, H.2    Carlson, R.W.3
  • 7
    • 0342902205 scopus 로고    scopus 로고
    • 'Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment'
    • Hrobjartsson, A. and Gotzsche, P.C. (2001), 'Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment', N. Engl. J. Med. Vol. 344, pp. 1594-1602.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1594-1602
    • Hrobjartsson, A.1    Gotzsche, P.C.2
  • 8
    • 0742288585 scopus 로고    scopus 로고
    • 'The complex interplay among factors that influence allelic association'
    • Zondervan, K.T. and Cardon, L.R. (2004), 'The complex interplay among factors that influence allelic association', Nat. Rev. Genet. Vol. 5, pp. 89-100.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2
  • 9
    • 0036094264 scopus 로고    scopus 로고
    • 'Power and efficiency of the TDT and case-control design for association scans'
    • McGinnis, R., Shifman, S. and Darvasi, A. (2002), 'Power and efficiency of the TDT and case-control design for association scans', Behav. Genet. Vol. 32, pp. 135-144.
    • (2002) Behav. Genet. , vol.32 , pp. 135-144
    • McGinnis, R.1    Shifman, S.2    Darvasi, A.3
  • 10
    • 0032827782 scopus 로고    scopus 로고
    • 'The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits'
    • Long, A.D. and Langley, C.H. (1999), 'The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits', Genome Res. Vol. 9, pp. 720-731.
    • (1999) Genome Res. , vol.9 , pp. 720-731
    • Long, A.D.1    Langley, C.H.2
  • 11
    • 0020744702 scopus 로고
    • 'Properties of a neutral allele model with intergenic recombination'
    • Hudson, R.R. (1983), 'Properties of a neutral allele model with intergenic recombination', Theor. Popul. Biol. Vol. 23, pp. 183-201.
    • (1983) Theor. Popul. Biol. , vol.23 , pp. 183-201
    • Hudson, R.R.1
  • 12
    • 0033816985 scopus 로고    scopus 로고
    • 'Testing drug response in the presence of genetic information: Sampling issues for clinical trials'
    • Cardon, L.R., Idury, R.M., Harris, T.J. (2000), 'Testing drug response in the presence of genetic information: Sampling issues for clinical trials', Pharmacogenetics Vol. 10, pp. 503-510.
    • (2000) Pharmacogenetics , vol.10 , pp. 503-510
    • Cardon, L.R.1    Idury, R.M.2    Harris, T.J.3
  • 13
    • 0142057099 scopus 로고    scopus 로고
    • 'The nested case-control study in cardiology'
    • Essebag, V., Genest, Jr., J., Suissa, S. et al. (2003), 'The nested case-control study in cardiology', Am. Heart J. Vol. 146, pp 581-590.
    • (2003) Am. Heart J. , vol.146 , pp. 581-590
    • Essebag, V.1    Genest Jr., J.2    Suissa, S.3
  • 14
    • 0035068773 scopus 로고    scopus 로고
    • 'Statistical multilocus methods for disequilibrium analysis in complex traits'
    • Ott, J. and Hoh, J. (2001), 'Statistical multilocus methods for disequilibrium analysis in complex traits', Hum. Mutat. Vol. 17, pp. 285-288.
    • (2001) Hum. Mutat. , vol.17 , pp. 285-288
    • Ott, J.1    Hoh, J.2
  • 15
    • 18544386196 scopus 로고    scopus 로고
    • 'Muld-locus interactions predict risk for post-PTCA restenosis: An approach to the genetic analysis of common complex disease'
    • Zee, R.Y., Hoh, J., Cheng, S. et al. (2002), 'Muld-locus interactions predict risk for post-PTCA restenosis: An approach to the genetic analysis of common complex disease', Pharmacogenomics J. Vol. 2, pp. 197-201.
    • (2002) Pharmacogenomics J. , vol.2 , pp. 197-201
    • Zee, R.Y.1    Hoh, J.2    Cheng, S.3
  • 16
    • 0037080655 scopus 로고    scopus 로고
    • 'Sample size requirements for matched case-control studies of gene-environment interaction'
    • Gauderman, W.J. (2002), 'Sample size requirements for matched case-control studies of gene-environment interaction', Stat. Med. Vol. 21, pp. 35-50.
    • (2002) Stat. Med. , vol.21 , pp. 35-50
    • Gauderman, W.J.1
  • 17
    • 0037229082 scopus 로고    scopus 로고
    • 'On selecting markets for association studies: Patterns of linkage disequilibrium between two and three diallelic loci'
    • Garner, C. and Slatkin, M. (2003), 'On selecting markets for association studies: patterns of linkage disequilibrium between two and three diallelic loci', Genet. Epidemiol. Vol. 24, pp. 57-67.
    • (2003) Genet. Epidemiol. , vol.24 , pp. 57-67
    • Garner, C.1    Slatkin, M.2
  • 18
    • 0002448168 scopus 로고    scopus 로고
    • 'Population association'
    • Balding D.J. Bishop M. Cannings C. (eds), John Wiley and Sons NewYork NY
    • Clayton, D. (2001), 'Population association', in Balding, D.J., Bishop, M., Cannings, C. (eds), Handbook of Statistical Genetics, John Wiley and Sons, NewYork, NY, pp. 519-540.
    • (2001) Handbook of Statistical Genetics , pp. 519-540
    • Clayton, D.1
  • 19
    • 0036184745 scopus 로고    scopus 로고
    • 'Generating samples under a Wright-Fisher neutral model of genetic variation'
    • Hudson, R.R. (2002), 'Generating samples under a Wright-Fisher neutral model of genetic variation', Bioinformatics Vol. 18, pp. 337-338.
    • (2002) Bioinformatics , vol.18 , pp. 337-338
    • Hudson, R.R.1
  • 20
    • 33646174532 scopus 로고    scopus 로고
    • 'The logistic procedure' chapter 39
    • Anon. Version 8, SAS Publishing, SAS Institute Inc Cary, NC
    • Anon. (1999), 'The logistic procedure' chapter 39 in SAS/STAT User's Guide, Version 8, SAS Publishing, SAS Institute Inc Cary, NC, pp. 1903-2044.
    • (1999) SAS/STAT User's Guide , pp. 1903-2044
  • 21
    • 0028151261 scopus 로고
    • 'Empirical threshold values for quantitative trait mapping'
    • Churchill, G.A. and Doerge, R.W. (1994), 'Empirical threshold values for quantitative trait mapping', Genetics Vol. 138, pp. 963-971.
    • (1994) Genetics , vol.138 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 22
    • 0033947901 scopus 로고    scopus 로고
    • 'Circumventing multiple testing: A multilocus Monte Carlo approach to testing for association'
    • McIntyre, L.M., Martin, E.R., Simonsen, K.L. et al. (2000), 'Circumventing multiple testing: A multilocus Monte Carlo approach to testing for association', Genet. Epidemiol. Vol. 19, pp. 18-29.
    • (2000) Genet. Epidemiol. , vol.19 , pp. 18-29
    • McIntyre, L.M.1    Martin, E.R.2    Simonsen, K.L.3
  • 23
    • 0035071957 scopus 로고    scopus 로고
    • 'A new statistical method for haplotype reconstruction from population data'
    • Stephens, M., Smith, N.J. and Donnelly, P. (2001), 'A new statistical method for haplotype reconstruction from population data', Am. J. Hum. Genet. Vol. 68, pp. 978-989.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 24
    • 12244264435 scopus 로고    scopus 로고
    • 'Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits'
    • Purcell, S., Cherny, S.S. and Sharn, P.C. (2003), 'Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits', Bioinformatics Vol. 19, pp. 149-150.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sharn, P.C.3
  • 25
    • 0029805706 scopus 로고    scopus 로고
    • 'The new genomics: Global views of biology'
    • Lander, E.S. (1996), 'The new genomics: Global views of biology', Science Vol, 274, pp. 536-539.
    • (1996) Science , vol.274 , pp. 536-539
    • Lander, E.S.1
  • 26
    • 0036799545 scopus 로고    scopus 로고
    • 'The allelic architecture of human disease genes: Common disease-common variant... or not?'
    • Pritchard, J.K. and Cox, N.J. (2002), 'The allelic architecture of human disease genes: Common disease-common variant... or not?', Hum. Mol. Genet. Vol. 11, pp, 2417-2423.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2417-2423
    • Pritchard, J.K.1    Cox, N.J.2
  • 27
    • 79959503826 scopus 로고    scopus 로고
    • 'The International HapMap Project'
    • The International HapMap Consortium
    • The International HapMap Consortium (2003), 'The International HapMap Project', Nature Vol. 426, pp. 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 28
    • 0033766857 scopus 로고    scopus 로고
    • 'Cladistic structure within the human lipoprotein lipase gene and its implications for phenotypic association studies'
    • Templeton, A.R., Weiss, K.M., Nickerson, D.A. et al. (2000), 'Cladistic structure within the human lipoprotein lipase gene and its implications for phenotypic association studies', Genetics Vol. 156, pp. 1259-1275.
    • (2000) Genetics , vol.156 , pp. 1259-1275
    • Templeton, A.R.1    Weiss, K.M.2    Nickerson, D.A.3
  • 29
    • 13444269543 scopus 로고    scopus 로고
    • 'Haploview: Analysis and visualization of LD and haplotype maps'
    • Barrett, J.C., Fry, B., Maller, J. et al. (2005), 'Haploview: Analysis and visualization of LD and haplotype maps', Bioinformatics Vol. 21, pp. 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3
  • 30
    • 0035029051 scopus 로고    scopus 로고
    • 'Issues concerning association studies for fine mapping a susceptibility gene for a complex disease'
    • Kaplan, N. and Morris, R. (2001), 'Issues concerning association studies for fine mapping a susceptibility gene for a complex disease', Genet. Epidemol. Vol. 20, pp. 432-457.
    • (2001) Genet. Epidemol. , vol.20 , pp. 432-457
    • Kaplan, N.1    Morris, R.2
  • 31
    • 0023425198 scopus 로고
    • 'A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila'
    • Templeton, A.R., Boerwinkle, E. and Sung, C.F. (1987), 'A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila', Genetics Vol. 117, pp. 343-351.
    • (1987) Genetics , vol.117 , pp. 343-351
    • Templeton, A.R.1    Boerwinkle, E.2    Sung, C.F.3
  • 32
    • 0038449167 scopus 로고    scopus 로고
    • 'Evolutionary-based association analysis using haplotype data'
    • Seltman, H., Roeder, K. and Devlin, B. (2003), 'Evolutionary-based association analysis using haplotype data', Genet. Epidemiol. Vol. 25, pp. 48-58.
    • (2003) Genet. Epidemiol. , vol.25 , pp. 48-58
    • Seltman, H.1    Roeder, K.2    Devlin, B.3
  • 33
    • 0035058585 scopus 로고    scopus 로고
    • 'Haplotypes vs single marker linkage disequilibrium tests: What do we gain?'
    • Akey, J., Jin, L. and Xiong, M. (2001), 'Haplotypes vs single marker linkage disequilibrium tests: What do we gain?', Eur. J. Hum. Genet. Vol. 9, pp. 291-300.
    • (2001) Eur. J. Hum. Genet , vol.9 , pp. 291-300
    • Akey, J.1    Jin, L.2    Xiong, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.