Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra)

Journal of Periodontology

Volumn 77, Issue 2, 2006, Pages 271-279

  Harokopakis, Evlambia ^a   Albzreh, Mohamad H ^a   Haase, Elaine M ^b   Scannapieco, Frank A ^b   Hajishengallis, George ^c,d  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actinobacillus actinomycetemcomitans; Cytokines; Inflammation; Nuclear factor kappa B; Porphyromonas gingivalis; Sambucus nigra

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; SAMBUCUS NIGRA EXTRACT; UNCLASSIFIED DRUG; AUTACOID; CD11B ANTIGEN; CD18 ANTIGEN; INTERLEUKIN DERIVATIVE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; VIRULENCE FACTOR;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG SYNTHESIS; FIMBRIA; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NEUTROPHIL; NONHUMAN; OXIDATION; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SAMBUCUS NIGRA; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; FLOWER; IMMUNOLOGY; MOUSE; RESPIRATORY BURST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD11B; ANTIGENS, CD18; FIMBRIAE, BACTERIAL; FLOWERS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MONOCYTES; NEUTROPHILS; NF-KAPPA B; PLANT EXTRACTS; PORPHYROMONAS GINGIVALIS; RESPIRATORY BURST; SAMBUCUS NIGRA; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE FACTORS;

EID: 33646169442     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2006.050232     Document Type: Article

References (38)

1. Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med 2000;343:338-344.
2. Zuany-Amorim C, Hastewell J, Walker C. Toll-like receptors as potential therapeutic targets for multiple diseases. Nature Rev Drug Discov 2002;1:797-807.
3. Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004;4:512-520.
4. Van Dyke TE, Serhan CN. Resolution of inflammation: A new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003;82:82-90.
5. Hajishengallis G, Sharma A, Russell MW, Genco RJ. Interactions of oral pathogens with Toll-like receptors: Possible role in atherosclerosis. Ann Periodontol 2002;7:72-78.
6. Hajishengallis G, Sojar H, Genco RJ, DeNardin E. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors. Immunol Invest 2004; 33:157-172.
7. Gibson FC 3rd, Hong C, Chou HH, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004;109:2801-2806.
8. Muthukuru M, Jotwani R, Cutler CW. Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infect Immun 2005;73:687-694.
9. Bainbridge BW, Darveau RP. Porphyromonas gingivalis lipopolysaccharide: An unusual pattern recognition receptor ligand for the innate host defense system. Acta Odontol Scand 2001;59:131-138.
10. Calixto JB, Otuki MF, Santos AR. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor κB (NF-κB). Planta Med 2003;69:973-983.
11. Ramirez-Tortosa MC, Mesa MD, Aguilera MC, et al. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis 1999;147:371-378.
12. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001;21:8370-8377.
13. Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol 2002;168:6506-6513.
14. Anderson MK. Blue elderberry - Sambucus nigra L. ssp. canadensis (L.) R. Bolli. United States Department of Agriculture Natural Resources Conversation Service National Plant Data Center; 2000. Available at: http://plants.usda.gov.
15. Borchers AT, Keen CL, Stern JS, Gershwin ME. Inflammation and Native American medicine: The role of botanicals. Am J Clin Nutr 2000;72:339-347.
16. Zambon JJ, Grossi S, Dunford R, Harazsthy VI, Preus H, Genco RJ. Epidemiology of subgingival bacterial pathogens in periodontal diseases. In: Genco RJ, Hamada S, Lehner T, McGhee JR, Mergenhangen S, eds. Molecular Pathogenesis of Periodontal Disease. Washington, D.C.: American Society of Microbiology; 1994:3-12.
17. Hajishengallis G, Martin M, Schifferle RE, Genco RJ. Counteracting interactions between lipopolysaccharide molecules with differential activation of Toll-like receptors. Infect Immun 2002;70:6658-6664.
18. Yoshimura A, Kaneko T, Kato Y, Golenbock DT, Hara Y. Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun 2002;70:218-225.
19. Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: Epidemiology and possible mechanisms. J Am Dent Assoc 2002; 133(Suppl.): 14S-22S.
20. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000;71:1554-1560.
21. Baker PJ. The role of immune responses in bone loss during periodontal disease. Microbes Infect 2000;2: 1181-1192.
22. Preshaw PM, Schifferle RE, Walters JD. Porphyromonas gingivalis lipopolysaccharide delays human polymorphonuclear leukocyte apoptosis in vitro. J Periodontal Res 1999;34:197-202.
23. Lee J-Y, Sojar HT, Amano A, Genco RJ. Purification of major fimbrial proteins of Porphyromonas gingivalis. Protein Expr Purif 1995;6:496-500.
24. Harokopakis E, Hajishengallis G. Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol 2005;35:1201-1210.
25. Hajishengallis G, Tapping RI, Martin MH, et al. Toll-like receptor 2 mediates cellular activation by the B sub-units of type II heat-labile enterotoxins. Infect Immun 2005;73:1343-1349.
26. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation. J Immunol 1983;130:1910-1917.
27. Hertz CJ, Kiertscher SM, Godowski PJ, et al. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol 2001;166:2444-2450.
28. 2 integrins. Curr Top Med Chem 2004; 4:1485-1495.
29. Arbibe L, Mira JP, Teusch N, et al. Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway. Nat Immunol 2000;1:533-540.
30. Laudanna C, Kim JY, Constantin G, Butcher EC. Rapid leukocyte integrin activation by chemokines. Immunol Rev 2002;186:37-46.
31. Ehlers MR. CR3: A general purpose adhesion-recognition receptor essential for innate immunity. Microbes Infect 2000;2:289-294.
32. Lamont RJ, Jenkinson HF. Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998;62:1244-1263.
33. Urbanek M, Pospisilova M, Polasek M. On-line coupling of capillary isotachophoresis and zone electrophoresis for the assay of phenolic compounds in plant extracts. Electrophoresis 2002;23:1045-1052.
34. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994;269:5241-5248.
35. Wu X, Gu L, Prior RL, McKay S. Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 2004;52: 7846-7856.
36. Rotelli AE, Guardia T, Juarez AO, de la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res 2003; 48:601-606.
37. Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 2003;74:391-401.
38. Wattel A, Kamel S, Prouillet C, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF-κB and AP-1. J Cell Biochem 2004;92:285-295.