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Volumn 39, Issue 16, 2003, Pages 1013-1023

Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes

Author keywords

Akt PKB; Con A; Thymocytes

Indexed keywords

CD3 ANTIGEN; CONCANAVALIN A; PHOSPHATIDYLINOSITOL KINASE; PROTEIN BAD; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR;

EID: 0038394563     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(03)00044-0     Document Type: Article
Times cited : (30)

References (43)
  • 1
    • 0028025078 scopus 로고
    • Characteristics of an in vitro system of thymocyte positive selection
    • Anderson G., Owen J.J.T., Moore N.C., Jenkinson E.J. Characteristics of an in vitro system of thymocyte positive selection. J. Immunol. 153:1994;1915-1920.
    • (1994) J. Immunol. , vol.153 , pp. 1915-1920
    • Anderson, G.1    Owen, J.J.T.2    Moore, N.C.3    Jenkinson, E.J.4
  • 2
    • 0029967353 scopus 로고    scopus 로고
    • Intracellular signalling pathways involved in the induction of apoptosis in immature thymic T lymphocytes
    • Anderson K.L., Anderson G., Michell R.H., Jenkinson E.J., Owen J.J.T. Intracellular signalling pathways involved in the induction of apoptosis in immature thymic T lymphocytes. J. Immunol. 156:1996;4083-4091.
    • (1996) J. Immunol. , vol.156 , pp. 4083-4091
    • Anderson, K.L.1    Anderson, G.2    Michell, R.H.3    Jenkinson, E.J.4    Owen, J.J.T.5
  • 6
    • 0030977267 scopus 로고    scopus 로고
    • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
    • Cheng E.C., Chan K.M., Cado D., Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16:1997;1865-1875.
    • (1997) EMBO J. , vol.16 , pp. 1865-1875
    • Cheng, E.C.1    Chan, K.M.2    Cado, D.3    Winoto, A.4
  • 7
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell intrinsic death machinery
    • Datta S.R., Dudek H., Tao Z., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell intrinsic death machinery. Cell. 91:1997;231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, Z.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 8
    • 0343457526 scopus 로고    scopus 로고
    • Reversible phosphorylation of Bcl2 following interleukin 3 or Bryostatin 1 is mediated by direct interaction with protein phosphatase 2A
    • Deng X., Ito T., Carr B., Mumby M., May W.S. Jr. Reversible phosphorylation of Bcl2 following interleukin 3 or Bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J. Biol. Chem. 273:1998;34157-34163.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34157-34163
    • Deng, X.1    Ito, T.2    Carr, B.3    Mumby, M.4    May W.S., Jr.5
  • 9
    • 0031566693 scopus 로고    scopus 로고
    • A bad kinase makes good
    • Franke T.F., Cantley L.C. A bad kinase makes good. Nature. 390:1997;116-117.
    • (1997) Nature , vol.390 , pp. 116-117
    • Franke, T.F.1    Cantley, L.C.2
  • 10
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke T.F., Kaplan D.R., Cantley L.C. PI3K: downstream AKTion blocks apoptosis. Cell. 88:1997;435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 11
    • 0030584079 scopus 로고    scopus 로고
    • Apoptosis meets signal transduction: Elimination of a BAD influence
    • Gajewski T.F., Thompson C.B. Apoptosis meets signal transduction: elimination of a BAD influence. Cell. 87:1996;589-592.
    • (1996) Cell , vol.87 , pp. 589-592
    • Gajewski, T.F.1    Thompson, C.B.2
  • 14
    • 0030959304 scopus 로고    scopus 로고
    • Bcl2 phosphorylation required for anti-apoptosis function
    • Ito T., Deng X., Carr B., May W.S. Bcl2 phosphorylation required for anti-apoptosis function. J. Biol. Chem. 272:1997;11671-11673.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 16
    • 0031715510 scopus 로고    scopus 로고
    • Expression of Tcf-1 mRNA and surface TCR-CD3 complexes are reduced during apoptosis of T cells
    • Jeon H.S., Jeong S., Lee C., Kim J.K., Kim Y.S., Park S.D., Seong R.H. Expression of Tcf-1 mRNA and surface TCR-CD3 complexes are reduced during apoptosis of T cells. Int. Immunol. 10:1998;1519-1527.
    • (1998) Int. Immunol. , vol.10 , pp. 1519-1527
    • Jeon, H.S.1    Jeong, S.2    Lee, C.3    Kim, J.K.4    Kim, Y.S.5    Park, S.D.6    Seong, R.H.7
  • 17
    • 0034658320 scopus 로고    scopus 로고
    • Protein kinase B regulates T lymphocyte survival, nuclear factor kB activation, and Bcl-XL levels in vivo
    • Jones R.G., Parsons M., Bonnard M., Chan V.S.F., Yeh W.C., Woodgett J.R., Ohashi P.S. Protein kinase B regulates T lymphocyte survival, nuclear factor kB activation, and Bcl-XL levels in vivo. J. Exp. Med. 191:2000;1721-1733.
    • (2000) J. Exp. Med. , vol.191 , pp. 1721-1733
    • Jones, R.G.1    Parsons, M.2    Bonnard, M.3    Chan, V.S.F.4    Yeh, W.C.5    Woodgett, J.R.6    Ohashi, P.S.7
  • 18
    • 0029831662 scopus 로고    scopus 로고
    • Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes
    • Kishimoto H., Cai Z., Brunmark A., Jackson M.R., Peterson P.A., Sprent J. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184:1996;531-537.
    • (1996) J. Exp. Med. , vol.184 , pp. 531-537
    • Kishimoto, H.1    Cai, Z.2    Brunmark, A.3    Jackson, M.R.4    Peterson, P.A.5    Sprent, J.6
  • 19
    • 0029000942 scopus 로고
    • Ceramide: A signal for apoptosis or mitogenesis?
    • Kolesnik R., Fuks Z. Ceramide: a signal for apoptosis or mitogenesis? J. Exp. Med. 181:1995;1949-1952.
    • (1995) J. Exp. Med. , vol.181 , pp. 1949-1952
    • Kolesnik, R.1    Fuks, Z.2
  • 21
    • 0033981892 scopus 로고    scopus 로고
    • Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors
    • Lovatt M., Yang T.-H., Stauss H.J., Fisher A.G., Merkenschlager M. Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors. Eur. J. Immunol. 30:2000;371-381.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 371-381
    • Lovatt, M.1    Yang, T.-H.2    Stauss, H.J.3    Fisher, A.G.4    Merkenschlager, M.5
  • 23
    • 0028399359 scopus 로고
    • Role of LFA-1/ICAM-1 in the activation of murine thymocytes stimulated by Con A
    • Lu L.S., Chen W.F. Role of LFA-1/ICAM-1 in the activation of murine thymocytes stimulated by Con A. Shi Yan Sheng Wo Xue Bao. 27:1994;71-77.
    • (1994) Shi Yan Sheng Wo Xue Bao , vol.27 , pp. 71-77
    • Lu, L.S.1    Chen, W.F.2
  • 25
    • 0030797727 scopus 로고    scopus 로고
    • Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
    • Miller T.M., Moulder K.L., Knudson C.M., Creedon D.J., Deshmukh M., Korsmeyer S.J., Johnson E.J. Jr. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J. Cell Biol. 139:1997;205-217.
    • (1997) J. Cell Biol. , vol.139 , pp. 205-217
    • Miller, T.M.1    Moulder, K.L.2    Knudson, C.M.3    Creedon, D.J.4    Deshmukh, M.5    Korsmeyer, S.J.6    Johnson E.J., Jr.7
  • 26
    • 0027538142 scopus 로고
    • Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction
    • Moore N.C., Anderson G., Smith C.A., Owen J.J.T., Jenkinson E.J. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur. J. Immunol. 23:1993;922-927.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 922-927
    • Moore, N.C.1    Anderson, G.2    Smith, C.A.3    Owen, J.J.T.4    Jenkinson, E.J.5
  • 27
    • 0028875818 scopus 로고
    • Stimulation of thymocytes before and after positive selection results in the induction of different NK-kB/Rel protein complexes
    • Moore N.C., Girdlestone J., Anderson G., Owen J.J.T., Jenkinson E.J. Stimulation of thymocytes before and after positive selection results in the induction of different NK-kB/Rel protein complexes. J. Immunol. 155:1995;4653-4660.
    • (1995) J. Immunol. , vol.155 , pp. 4653-4660
    • Moore, N.C.1    Girdlestone, J.2    Anderson, G.3    Owen, J.J.T.4    Jenkinson, E.J.5
  • 28
    • 0028151819 scopus 로고
    • Negative selection of lymphocytes
    • Nossal G.J.V. Negative selection of lymphocytes. Cell. 76:1994;229-239.
    • (1994) Cell , vol.76 , pp. 229-239
    • Nossal, G.J.V.1
  • 29
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 32
    • 0032566717 scopus 로고    scopus 로고
    • A functional role for mitochondrial protein kinase C alpha in Bcl2 phosphorylation and suppression of apoptosis
    • Ruvolo P.P., Deng X., Carr B.K., May W.S. A functional role for mitochondrial protein kinase C alpha in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 273:1998;25436-25442.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25436-25442
    • Ruvolo, P.P.1    Deng, X.2    Carr, B.K.3    May, W.S.4
  • 33
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • Ruvolo P.P., Deng X., Ito T., Carr B.D., May W.S. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274:1999;20296-20300.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20296-20300
    • Ruvolo, P.P.1    Deng, X.2    Ito, T.3    Carr, B.D.4    May, W.S.5
  • 37
    • 0024492086 scopus 로고
    • Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cell in thymic cultures
    • Smith C.A., Williams G.T., Kingstion R., Jenkinson E.J., Owen J.J. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cell in thymic cultures. Nature. 337:1989;181-184.
    • (1989) Nature , vol.337 , pp. 181-184
    • Smith, C.A.1    Williams, G.T.2    Kingstion, R.3    Jenkinson, E.J.4    Owen, J.J.5
  • 38
    • 0033584231 scopus 로고    scopus 로고
    • Bcl2-mediated drug resistance: Inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas Ligand transcription
    • Srivastava R.K., Sasaki C.Y., Hardwick J.M., Longo D.L. Bcl2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas Ligand transcription. J. Exp. Med. 190:1999;253-265.
    • (1999) J. Exp. Med. , vol.190 , pp. 253-265
    • Srivastava, R.K.1    Sasaki, C.Y.2    Hardwick, J.M.3    Longo, D.L.4
  • 39
    • 0028117306 scopus 로고
    • Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
    • Strasser A., Harris A.W., von Boehmer H., Cory S. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl. Acad. Sci. U.S.A. 91:1994;1376-1380.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 1376-1380
    • Strasser, A.1    Harris, A.W.2    Von Boehmer, H.3    Cory, S.4
  • 40
    • 0025908328 scopus 로고
    • T-cell differentiation is influenced by thymic microenvironments
    • van Ewijk W. T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol. 9:1991;591-615.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 591-615
    • Van Ewijk, W.1
  • 42
    • 0029843074 scopus 로고    scopus 로고
    • Concanavalin A induces perforin-mediated but not Fas mediated hepatic injury
    • Watanabe Y., Morita M., Akaike T. Concanavalin A induces perforin-mediated but not Fas mediated hepatic injury. Hepatology. 24:1996;702-710.
    • (1996) Hepatology , vol.24 , pp. 702-710
    • Watanabe, Y.1    Morita, M.2    Akaike, T.3
  • 43
    • 0031079710 scopus 로고    scopus 로고
    • Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas
    • Winoto A. Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas. Semin. Immunol. 9:1997;51-58.
    • (1997) Semin. Immunol. , vol.9 , pp. 51-58
    • Winoto, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.