Immunotoxicity of the pyrethroid insecticides deltametrin and α-cypermetrin

Toxicology

Volumn 107, Issue 3, 1996, Pages 219-227

  Madsen, Charlotte ^a   Claesson, Mogens H ^b   Röpke, Carsten ^b  

^a National Food Agency of Denmark   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

CAS no. 52918 63 5; CAS no. 67375 30 8; Deltametrin; Immunotoxicity; Rat; Stereology; Cypermetrin

Indexed keywords

CIPERMETHRIN; DELTAMETHRIN; MITOGENIC AGENT; PYRETHROID;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOPSY; BONE MARROW CELL; CONTROLLED STUDY; IMMUNOTOXICITY; MALE; MESENTERY LYMPH NODE; NATURAL KILLER CELL; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; SPLEEN CELL; STEREOLOGY; THYMUS;

ANIMALIA; PHASEOLUS (ANGIOSPERM);

EID: 0030021107     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(95)03244-A     Document Type: Article

References (19)

1. Claesson, M.H., Malte, L., Sorribes, M. and Nissen, M.H. (1995) Immunomodulation by vitamin C and minerals in humans. A controlled, double blind study with young, healthy adults. Life Sci. Adv., Allergy Immunol., in press.
2. Crofton, K.M. and Reiter, L.W. (1984) Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. Toxicol. Appl. Pharmacol. 75, 318-328.
3. Cunningham, A.J. and Szenberg, A. (1968) Further improvements in the plaque technique for detecting single antibody-forming cells Immunology 14, 599.
4. Dési, I., Dobronyia, I. and Varga, L. (1986) Immuno-, neuro-, and general toxicologic animal studies on a synthetic pyrethroid: cypermetrin. Ecotoxicol. Environ. Saf. 12, 220-232.
5. De Waal, E.J., Schuurmann, H.-J., Rademakers, L.H.P.M., Van Loveren, H. and Vos, J.G. (1993) The cortical epithelium of the rat thymus after in vivo exposure to bis(tri-n-butyltin)oxide (TBTO). Arch. Toxicol. 67, 186-192.
6. Felten, S.Y., Felten, D.L., Bellinger, D.L. and Olschowka, J.A. (1992) Noradrenergic and peptidergic innervation of lymphoid organs. In: Blalock, J.E. (Ed), Neuroimmunoendocrinology, 2nd edn., Karger, Basel, pp. 25-48.
7. Fuchs, B.A. and Sanders, V.M. (1994) The role of brain-immune interactions in immunotoxicology. Crit. Rev. Toxicol. 24, 151-176.
8. Gundersen, H.J.G., Bendtsen, T.F., Korbo, L., Marcussen, N., Moller A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B., Sorensen, F.B., Vesterby, A. and West, M.J. (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379-394.
9. ICISIS (1995) International Collaborative Immunotoxicity Study: Phase II, Report of the Interlaboratory Comparison of the effects of Cyclosporin on Pathology, Enhanced Pathology and Functional Tests of Immunotoxicity In the Rat, in press.
10. Imai, K. (1990) Athrophy of thymus induced by cytostatic chemicals, rat. In: Jones, T.C., Ward, J.M., Mohr, U. and Hunt, R.D. (Eds.), Monographs on Pathology of Laboratory Animals, Hemopoietic System, Springer Verlag, Berlin, pp. 293-295.
11. International Program on Chemical Safety (1990). Environmental Health Criteria 97, Alpha-cypermetrin, WHO, Geneva, p. 15.
12. International Program on Chemical Safety (1992). Environmental Health Criteria 142, Alpha-cypermetrin, WHO, Geneva, p. 13.
13. Kowalczyk-Bronisz, S.H., Gieldanowski, J. and Bubak, B. (1990) Immunological profile of animals exposed to pesticide - deltametrin. Arch. Immunol. Therap. Exp. 38, 229-238.
14. Lukowicz-Ratajcak, J. and Krechniak J. (1992). Effects of deltametrin on the immune system in mice. Environ. Res. 59, 467-475.
15. Maurer, J.K., Gibbons, B.A. and Bruce, R.D. (1990) Morphometric assessment of thymic size variation in laboratory rabbits. Toxicol. Pathol. 18, 407-411.
16. Röpke, C., Tscherning, T. and Claesson, M.H. (1993) Regulatory effects in vitro by thymic medullary epithelial cells on TCR transgenic T cells specific for male H-Y antigens. Immunol. Lett. 37, 167-174.
17. Schuurmann, H.-J. et al. (1992) Comparative evaluation of the immune status of congenitally athymic and euthymic rat strains bred and maintained at different institutes. 1. Euthymic rats. J. Exp. Anim. Sci. 35, 16-32.
18. Siroki, O., Institoris, L., Tatar, E. and Desi, I. (1994) Immunotoxicological investigation of SCMF, a new pyrethroid pesticide in mice. Hum. Exp. Toxicol. 13, 337-343.
19. Stelzer, K.J. and Gordon, M.A. (1984) Effects of pyrethroids on lymphocyte mitogenic responsiveness. Res. Commun. Chem. Pathol. Pharmacol. 46, 137-150.