Effect of transmitters and co-transmitters of the sympathetic nervous system on interleukin-6 synthesis in thymic epithelial cells

NeuroImmunoModulation

Volumn 6, Issue 1-2, 1999, Pages 45-50

  Von Patay, Birte ^a   Kurz, Bodo ^a   Mentlein, Rolf ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Adenosine triphosphate; Adrenoceptors; Catecholamines; Interleukin 6; Noradrenaline; Purines; Thymic epithelial cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATECHOLAMINE; INTERLEUKIN 6; NORADRENALIN;

ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; CATECHOLAMINE RELEASE; CELL DIFFERENTIATION; CELL PROLIFERATION; EPITHELIUM CELL; FIBROBLAST; LIGAND BINDING; MAST CELL; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; TARGET CELL; THYMUS;

ADENOSINE TRIPHOSPHATE; ADRENERGIC BETA-AGONISTS; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; INTERLEUKIN-6; NOREPINEPHRINE; RATS; SYMPATHOMIMETICS; THYMUS GLAND;

EID: 0032967985     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026363     Document Type: Article

References (26)

1. Boyd RL, Tucek CL, Godfrey DI, Izon DJ, Wilson TJ, Davidson DJ, Bean AGD, Ladyman HM, Ritter MA, Hugo P: The thymic microenvironment. Immunol Today 1993;14: 445-459.
2. Kendall MD: Functional anatomy of the thymus microenviroment. J Anat 1991;177:1-29.
3. Le PT, Singer KH: Human thymic epithelial cells: Adhesion molecules and cytokine production. Int J Clin Lab Res 1987;23:56-60.
4. WolfSS, Cohen A: Expression of cytokines and their receptors by human thymocytes and thymic stromal cells. Immunology 1992;77: 362-368.
5. Kurz B, von Gaudecker B, Kranz A, Krisch B, Mentlein R: Calcitonin gene-related peptide and its receptor in the thymus. Peptides 1995; 16:1497-1503.
6. Kendall MD: The thymus: New views of an old gland. Endeavour 1992;16:158-163.
7. Kurz B, Feindt J, von Gaudecker B, Kranz A, Loppnow H, Mentlein R: β-Adrenoceptor-mediated effects in rat cultured thymic epithelial cells. Br J Pharmacol 1997;120:1401-1408.
8. Kendall MD, Al-Shawaf H, Zaidi SA: The cholinergic and adrenergic innervation of the rat thymus. Adv Exp Med Biol 1998;237:255-261.
9. Kendall MD, Atkinson BA, Muńoz FJ, de la Riva C, Clarke A, von Gaudecker B: The noradrenergic innervation of the rat thymus during pregnancy and in the post partum period. J Anat 1994;185:617-625.
10. Linden J: Purinergic systems; in Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds): Basic Neurochemistry. New York, Raven Press, 1993, pp 401-416.
11. Malec D: Purinergic receptors. Pol J Pharmacol 1996;48:457-465.
12. Kurz B, von Gaudecker B, Krisch B, Mentlein R: Rat thymic epithelial cells in vitro and in situ: Characterisation by immunocytochemistry and morphology. Cell Tissue Res 1996;283: 221-229.
13. Karsten U, Wollenberger A: Improvements of the ethidium bromide method for direct fluorometric estimation of DNA and RNA in cell and tissue homogenates. Anal Biochem 1977;77: 464-470.
14. von Patay B, Loppnow H, Feindt J, Kurz B, Mentlein R: Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells. J Neuroimmunol 1998;86:182-189.
15. 2 production in thymic epithelial cells. Biochem J 1995;308:399-404.
16. Tanabe OS, Akira T, Kamiya GG, Wong T, Hirano T, Kishimoto T: Genomic structure of the murine IL-6 gene: High degree of conservation of potential regulatory sequences between mouse and human. J Immunol 1988;141: 3875-3881.
17. Kishimoto T: The biology of interleukin-6. Blood 1989;74:1-10.
18. Carding SR, Hayday AC, Bottomly K: Cytokines in T-cell development. Immunol Today 1991;12:239-245.
19. Takai Y, Wong GG, Clark SC, Burakoff SJ, Herman SH: B-cell stimulatory factor-2 is involved in the differentiation of cytotoxic T-lymphocytes. J Immunol 1987;40:508-513.
20. Chen W-F, Fischer M, Frank G, Zlotnik A: Distinct patterns of lymphokine requirement for the proliferation of various subpopulations of activated thymocytes in single cell assay. J Immunol 1989;143:1598-1605.
21. Suda T, Murray R, Guidos C, Zlotnik A: Growth-promoting activity of IL-1α, IL-6, and tumor necrosis factor-α in combination with IL-2, IL-4, or IL-7 on murine thymocytes. J Immunol 1990;144:3039-3045.
22. Le J, Frederick G, Reis LFL, Diamantstein T, Hirano T, Kishimoto T, Vileck J: Interleukin-2-dependent and interleukin-2-independent pathways of regulation of thymocyte function by interleukin 6. Proc Natl Acad Sci USA 1988; 85:8643-8647.
23. 2-interferon) functions as a second signal for interleukin-2 production by mature murine T cells. Proc Natl Acad Sci USA 1987;84:7629-7633.
24. Colic M, Pejnovic N, Kataranovski M, Popovic L, Gasic S, Dujic A: Interferon gamma alters the phenotype of rat thymic epithelial cells in culture and increases interleukin-6 production. Dev Immunol 1992;2:151-160.
25. Meilin A, Shoham J, Schreiber L, Sharabi Y: The role of thymocytes in regulating thymic epithelial cell growth and function. Scand J Immunol 1995;42:185-190.
26. Cohen-Kaminsky S, Devergne O, Delattre R-M, Klingel-Schmitt I, Emilie D, Galanaud P, Berrih-Akinin S: Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. Eur Cytokine Network 1993;4:121-132.