In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17β-estradiol-induced gene expression in several bioassay systems

Toxicological Sciences

Volumn 69, Issue 2, 2002, Pages 362-372

  Letcher, Robert J ^a,f   Lemmen, Josephine G ^b,c,d   Van Der Burg, Bart ^b,c,d   Brouwer, Abraham ^b,c,d   Bergman, Åke ^b,c,d   Giesy, John P ^e   Van Den Berg, Martin ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b HUBRECHT INSTITUTE   (Netherlands)

^c INSTITUTE FOR ENVIRONMENTAL STUDIES   (Netherlands)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e MICHIGAN STATE UNIVERSITY   (United States)

^f UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Antiestrogenicity; Estrogen responsive cells; Gene expression; In vitro bioassays; Methylsulfone metabolites; Polychlorinated biphenyls

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; ANTIESTROGEN; AROMATIC HYDROCARBON RECEPTOR; BENZENE DERIVATIVE; BIPHENYL DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; LUCIFERASE; MESYLIC ACID DERIVATIVE; ORGANOCHLORINE INSECTICIDE; POLYCHLORINATED BIPHENYL DERIVATIVE; TAMOXIFEN; VITELLOGENIN;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; BIOASSAY; BREAST ADENOCARCINOMA; CARP; CELL ASSAY; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; EMBRYO CELL; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KIDNEY CELL; LIVER CELL; MALE; METABOLITE; NONHUMAN; PROTEIN INTERACTION; RAT; WILDLIFE;

ADENOCARCINOMA; ANIMALS; BIPHENYL COMPOUNDS; BREAST NEOPLASMS; CARPS; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; DICHLORODIPHENYL DICHLOROETHYLENE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LUCIFERASES; MALE; POLYCHLORINATED BIPHENYLS; RATS; TAMOXIFEN; VITELLOGENINS;

ANIMALIA; CYPRINUS CARPIO;

EID: 0036772429     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.2.362     Document Type: Article

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