Genetic determinants of the metabolic syndrome

Current Hypertension Reports

Volumn 8, Issue 1, 2006, Pages 16-22

  Sale, Michèle M ^b   Woods, Jonathan ^b   Freedman, Barry I ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; COHORT ANALYSIS; EVIDENCE BASED MEDICINE; FAMILIAL DISEASE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; METABOLIC SYNDROME X; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; REVIEW;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); METABOLIC SYNDROME X;

EID: 33646051536     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-006-0036-5     Document Type: Review

References (50)

1. Bjorntorp P: Metabolic implications of body fat distribution. Diabetes Care 1991, 14:1132-1143.
2. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998, 15:539-553.
3. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
4. Alexander CM, Landsman PB, Teutsch SM, Haffner SM: NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003, 52:1210-1214.
5. Lindsay RS, Howard BV: Cardiovascular risk associated with the metabolic syndrome. Curr Diab Rep 2004, 4:63-68.
6. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356-359.
7. Hong Y, Pedersen NL, Brismar K, de Faire U: Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Genet 1997, 60:143-152.
8. Edwards KL, Newman B, Mayer E, et al.: Heritability of factors of the insulin resistance syndrome in women twins. Genet Epidemiol 1997, 14:241-253.
9. Carmelli D, Cardon LR, Fabsitz R: Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet 1994, 55:566-573.
10. Mayer EJ, Newman B, Austin MA, et al.: Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins. Am J Epidemiol 1996, 143:323-332.
11. Liese AD, Mayer-Davis EJ, Tyroler HA, et al.: Familial components of the multiple metabolic syndrome: the ARIC study. Diabetologia 1997, 40:963-970.
12. Chen W, Srinivasan SR, Elkasabany A, Berenson GS: The association of cardiovascular risk factor clustering related to insulin resistance syndrome (Syndrome X) between young parents and their offspring: the Bogalusa Heart Study. Atherosclerosis 1999, 145:197-205.
13. Hong Y, Rice T, Gagnon J, et al.: Familial clustering of insulin and abdominal visceral fat: the HERITAGE Family Study. J Clin Endocrinol Metab 1998, 83:4239-4245.
14. Li JK, Ng MC, So WY, et al.: Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus. Diabetes Metab Res Rev 2005, Epub ahead of print.
15. Meigs JB, D'Agostino RB Sr, Wilson PW, et al.: Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes 1997, 46:1594-1600.
16. Katzmarzyk PT, Perusse L, Malina RM, et al.: Stability of indicators of the metabolic syndrome from childhood and adolescence to young adulthood: the Quebec Family Study. J Clin Epidemiol 2001, 54:190-195.
17. Bao W, Srinivasan SR, Wattigney WA, Berenson GS: Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study. Arch Intern Med 1994, 154:1842-1847.
18. Mitchell BD, Kammerer CM, Mahaney MC, et al.: Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vasc Biol 1996, 16:281-288.
19. Rainwater DL, Mitchell BD, Mahaney MC, Haffner SM: Genetic relationship between measures of HDL phenotypes and insulin concentrations. Arterioscler Thromb Vasc Biol 1997, 17:3414-3419.
20. Kissebah AH, Sonnenberg GE, Myklebust J, et al.: Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 2000, 97: 14478-14483.
21. Hunt SC, Hasstedt SJ, Kuida H, et al.: Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol 1989, 129:625-638.
22. Freedman BI, Rich SS, Sale MM, et al.: Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families. Diabetologia 2005, 48:661-668.
23. Goldin LR, Camp NJ, Keen KJ, et al.: Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13. Genet Epidemiol 2003, 25(Suppl1):S78-S89.
24. Kraft P, de Andrade M: Group 6: pleiotropy and multivariate analysis. Genet Epidemiol 2003, 25(Suppl1): S50-S56.
25. McQueen MB, Bertram L, Rimm EB, et al.: A QTL genome scan of the metabolic syndrome and its component traits. BMC Genet 2003, 4(Suppl1):S96.
26. Stein CM, Song Y, Elston RC, et al.: Structural equation model-based genome scan for the metabolic syndrome. BMC Genet 2003, 4(Suppl1):S99.
27. Arya R, Blangero J, Williams K, et al.: Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans. Diabetes 2002, 51:841-847.
28. Langefeld CD, Wagenknecht LE, Rotter JI, et al.: Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study. Diabetes 2004, 53:1170-1174.
29. Hamet P, Merlo E, Seda O, et al.: Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet 2005, 76:815-832.
30. Loos RJ, Katzmarzyk PT, Rao DC, et al.: Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study. J Clin Endocrinol Metab 2003, 88:5935-5943.
31. McCarthy MI: Growing evidence for diabetes susceptibility genes from genome scan data. Curr Diab Rep 2003, 3:159-167.
32. Olswold C, de Andrade M: Localization of genes involved in the metabolic syndrome using multivariate linkage analysis. BMC Genet 2003, 4(Suppl1):S57.
33. Ng MC, So WY, Lam VK, et al.: Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes 2004, 53:2676-2683.
34. Cai G, Cole SA, Freeland-Graves JH, et al.: Principal component for metabolic syndrome risk maps to chromosome 4p in Mexican Americans: the San Antonio Family Heart Study. Hum Biol 2004, 76:651-665.
35. Tang W, Miller MB, Rich SS, et al.: Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. Diabetes 2003, 52:2840-2847.
36. Imperatore G, Knowler WC, Pettitt DJ, et al.: A locus influencing total serum cholesterol on chromosome 19p: results from an autosomal genomic scan of serum lipid concentrations in Pima Indians. Arterioscler Thromb Vasc Biol 2000, 20:2651-2656.
37. Krushkal J, Ferrell R, Mockrin SC, et al.: Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 1999, 99:1407-1410.
38. Cheng LS, Davis RC, Raffel LJ, et al.: Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families. Circulation 2001, 104:1255-1260.
39. Shearman AM, Ordovas JM, Cupples LA, et al.: Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study. Hum Mol Genet 2000, 9:1315-1320.
40. An P, Freedman BI, Hanis CL, et al.: Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 2005, 54:909-914.
41. Frederiksen L, Brodbaek K, Fenger M, et al.: Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 2002, 87:3989-3992.
42. Dallongeville J, Helbecque N, Cottel D, et al.: The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab 2003, 88:4862-4866.
43. Fernandez ML, Ruiz R, Gonzalez MA, et al.: Association of NOS3 gene with metabolic syndrome in hypertensive patients. Thromb Haemost 2004, 92:413-418.
44. Lee YJ, Tsai JC: ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care 2002, 25:1002-1008.
45. Jowett JB, Elliott KS, Curran JE, et al.: Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes. Diabetes 2004, 53:2467-2472.
46. Steinle NI, Kazlauskaite R, Imumorin IG, et al.: Variation in the lamin A/C gene: associations with metabolic syndrome. Arterioscler Thromb Vasc Biol 2004,24:1708-1713.
47. Hamid YH, Rose CS, Urhammer SA, et al.: Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 2005, 48:251-260.
48. Olivier M, Hsiung CA, Chuang LM, et al.: Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity. Hum Mol Genet 2004, 13:1885-1892.
49. Freedman BI, Langefeld CD, Lohman KK, et al.: Relationship between albuminuria and cardiovascular disease in type 2 diabetes. J Am Soc Nephrol 2005, 16:2156-2161.
50. Sale MM, Freedman BI, Langefeld CD, et al.: A genomewide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q. Diabetes 2004, 53:830-837.