Association of NOS3 gene with metabolic syndrome in hypertensive patients

Thrombosis and Haemostasis

Volumn 92, Issue 2, 2004, Pages 413-418

  Fernandez, Maria Luisa ^a   Ruiz, Rocio ^b   Gonzalez, Maria Angeles ^a   Ramirez Lorca, Reposo ^b   Couto, Carmen ^a   Ramos, Antonio ^a   Gutierrez Tous, Reyes ^a   Rivera, Jose Maria ^a   Ruiz, Agustin ^b   Real, Luis Miguel ^b   Grilo, Antonio ^a  

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b Edificio Acropolis Modulos 110 111   (Spain)

Author keywords

Genetics; Hypertension; Metabolic syndrome; NOS3; Polymorphism

Indexed keywords

CYTOSINE; DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANINE; THYMINE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM LESION; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 4444383628     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th04-02-0103     Document Type: Article

References (40)

1. Modan M, Halkin H, Almog S, et al.. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J Clin Invest 1985; 75: 809-17.
2. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
3. Mykkanen L, Zaccaro DJ, Wagenknecht LE, et al. Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study. Diabetes 1998; 47: 793-800.
4. Bjorntorp P. Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? Curr Opin Lipidol 1994; 5: 166-74.
5. Yudkin JS. Abnormalities of coagulation and fibrinolysis in insulin resistance. Evidence for a common antecedent? Diabetes Care 1999; 22 Suppl 3: C25-30.
6. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
7. Freeman MS, Mansfield MW, Barrett JH, et al. Insulin resistance: an atherothrombotic syndrome. The Leeds family study. Thromb Haemost 2003; 89: 161-8.
8. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey JAMA. 2002; 287: 356-9.
9. Meigs JB. Epidemiology of the metabolic syndrome. Am J Manag Care 2002; 8: S283-92.
10. Kovacs P, van den Brandt J, Kloting I. Genetic dissection of the syndrome X in the rat. Biochem Biophys Res Commun 2000; 269: 660-5.
11. Lee YJ, Tsai JC. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care 25: 1002-8.
12. Tang W, Miller MB, Rich SS, et al. Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. Diabetes 2003; 52: 2840-7.
13. Dallongeville J, Helbecque N, Cottel D, et al. The Gly16->Arg16 and Gln27->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab 2003; 88: 4862-6.
14. Duplain H, Burcelin R, Sartori C, et al. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 2001; 104: 342-5.
15. Lloyd-Jones DM, Bloch KD. The vascular biology of nitric oxide and its role in atherogenesis. Annu Rev Med 1996; 47: 365-75.
16. Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost 1993; 70: 36-41.
17. Huang PL, Huang Z, Mashimo, H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377: 239-42.
18. Forte P, Copland M, Smith LM, et al. Basal nitric oxide synthesis in essential hypertension. Lancet 1997; 349: 837-42.
19. Miyamoto Y, Saito Y, Kajiyama N, et al. 1998 Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 1998; 32: 3-8.
20. Hyndman ME, Parsons HG, Verma S, et al. The T-786->C mutation in endothelial nitric oxide synthase is associated with hypertension. Hypertension 2002; 39: 919-22.
21. Kato N, Sugiyama T, Morita H, et al. Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension. Hypertension 1999; 33: 933-6.
22. Tsujita Y, Baba S, Yamauchi R, et al. Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study. J Hypertens 2001; 19: 1941-8.
23. Ohtoshi K, Yamasaki Y, Gorogawa S, et al. Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance. Diabetologia 2002; 45: 1594-601.
24. Yoshimura T, Hisatomi A, Kajihara S, et al. The relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease. J Atheroscler Thromb 2003; 10: 43-7.
25. Monti LD, Barlassina C, Citterio L, et al. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes 2003; 52:1270-5.
26. Benjafield AV, Morris BJ. Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. Am J Hypertens 2000; 13: 994-8.
27. Ukkola O, Erkkila PH, Savolainen MJ, et al. 2001 Lack of association between polymorphisms of catalase, copper-zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patient with type 2 diabetes mellitus. J Intern Med 2001; 249: 451-9.
28. Meigs JB. Epidemiology of cardiovascular complications in type 2 diabetes mellitus. Acta Diabetol. 2003; 40 Suppl 2: S358-61.
29. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 Suppl 1: S5-20.
30. Allain CC, Poon LS, Chan CS, et al. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20: 470-5.
31. Friedelwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
32. Real LM, Gayoso AJ, Olivera M, et al. Detection of nucleotide c985 A->G mutation of medium-chain acyl-CoA dehydrogenase gene by real-time PCR. Clin Chem 2001; 47: 958-9.
33. Sasieni PD. From Genotypes to Genes: Doubling the Sample Size. Biometrics 1997; 53: 1253-61.
34. Banegas JR, Rodriguez-Artalejo F, de la Cruz Troca JJ, et al. Blood pressure in Spain: distribution, awareness, control, and benefits of a reduction in average pressure. Hypertension 1998; 32: 998-1002.
35. Tamayo-Marco B, Faure-Nogueras E, Roche-Asensio MJ, et al. Prevalence of diabetes and impaired glucose tolerance in Aragon, Spain. Diabetes Care 1997; 20: 534-6.
36. Nakayama M, Yasue H, Yoshimura M, et al. T-786->C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99: 2864-70.
37. Tesauro M, Thompson WC, Rogliani P, et al. Qi L, Chaudhary PP, Moss J Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci U S A 2000; 97: 2832-5.
38. Song J, Yoon Y, Park KU, et al. Genotype-specific influence on nitric oxide synthase gene expression, protein concentrations, and enzyme activity in cultured human endothelial cells. Clin Chem 2003; 49: 847-52.
39. Rossi GP, Taddei S, Virdis A, et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol 2003; 41: 938-45.
40. Cook S, Scherrer U. Insulin resistance, a new target for nitric oxide-delivery drugs. Fundam Clin Pharmacol 2002; 16: 441-53.