Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3953-3966

  Zhang, Shijun ^a   Zhen, Juan ^b   Reith, Maarten E A ^b   Dutta, Aloke K ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cocaine; Dopamine transporter; Norepinephrine transporter; Serotonin transporter

Indexed keywords

(6 BENZHYDRYLTETRAHYDROPYRAN 3 YL)BENZYLAMINE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BENZYLAMINE DERIVATIVE; DOPAMINE TRANSPORTER; GLYCOSIDE; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; TETRAHYDROPYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOPAMINE UPTAKE; DRUG DESIGN; DRUG SYNTHESIS; NONHUMAN; NORADRENALIN UPTAKE; RAT; SEROTONIN UPTAKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZYLAMINES; BINDING, COMPETITIVE; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PYRANS; RATS; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33646047698     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.051     Document Type: Article

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