Enantiopure purpurosamine C type glycosyl donors an improved access from rac-Acrolein dimer - Biocatalytic resolution

Tetrahedron Letters

Volumn 38, Issue 15, 1997, Pages 2653-2656

  Erbeck, Silke ^a   Prinzbach, Horst ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; PURPURIN DERIVATIVE;

ARTICLE; CHIRALITY; DRUG PURIFICATION; DRUG SYNTHESIS; GLYCOSYLATION; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY; THIN LAYER CHROMATOGRAPHY;

EID: 0030907277     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00448-6     Document Type: Article

References (31)

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24. 13C NMR, MS, IR, elemental analysis). For compounds 2-5 the pyran, for compounds 7-11, 13 the glycoside numbering is used.
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28. 3/ MeOH 10/1) provided 160 mg (37%) (5S)-9 and 300 mg (60%) 7. The acetate (5R)-7 was obtained by making use of more enzyme and longer reaction time (500 mg rac-7 (1.67 mmol), 15 mL acetone, 150 mL 0.1 M phosphate buffer, 75 mg PPL, after 3 d addition of another 50 mg PPL, reaction time 14 d, 138 mg (28%) (5R)-7 and 284 mg (66%) 9).
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