Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4962-4971

  Zhang, Shijun ^a   Zhen, Juan ^b,c   Reith, Maarten E A ^b,c   Dutta, Aloke K ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b ILLINOIS STATE UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZHYDRYL 5 (2,4 DIMETHOXYBENZYLAMINO)TETRAHYDROPYRAN 4 OL; 2 BENZHYDRYL 5 (4 METHOXYBENZYLAMINO)TETRAHYDROPYRAN 4 OL; 2 BENZHYDRYL 5 BENZYLAMINOTETRAHYDROPYRAN 4 OL; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 6 BENZHYDRYL 4 BENZYLAMINOTETRAHYDROPYRAN 3 OL; COCAINE; DOPAMINE; MONOAMINE DERIVATIVE; NORADRENALIN; NORADRENALIN TRANSPORTER; SEROTONIN; SEROTONIN TRANSPORTER; TETRAHYDROPYRAN DERIVATIVE; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASYMMETRIC CATALYSIS; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR INTERACTION; NONHUMAN; NORADRENALIN RELEASE; RAT; SEROTONINERGIC SYSTEM; STEREOSPECIFICITY; SUBSTITUTION REACTION;

ANIMALS; BENZHYDRYL COMPOUNDS; BRAIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PYRANS; RADIOLIGAND ASSAY; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 22844451687     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049021k     Document Type: Article

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