메뉴 건너뛰기




Volumn 8, Issue 1, 2006, Pages 35-44

The future of endothelin-receptor antagonism as treatment for systemic hypertension

Author keywords

[No Author keywords available]

Indexed keywords

AMBRISENTAN; ANTIHYPERTENSIVE AGENT; ATRASENTAN; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYCLOSPORIN A; DAGLUTRIL; DARUSENTAN; DIURETIC AGENT; ENALAPRIL; ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN CONVERTING ENZYME INHIBITOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHOSPHORAMIDON; PLACEBO; PROSTACYCLIN DERIVATIVE; RECOMBINANT ERYTHROPOIETIN; RENIN; SILDENAFIL; SITAXSENTAN; TEZOSENTAN;

EID: 33646021907     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-006-0039-2     Document Type: Review
Times cited : (7)

References (99)
  • 1
    • 0022067275 scopus 로고
    • Characterization of a coronary vasoconstrictor produced by cultured endothelial cells
    • Hickey KA, Rubanyi G, Paul RJ, et al.: Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 1985, 248:C550-C556.
    • (1985) Am J Physiol , vol.248
    • Hickey, K.A.1    Rubanyi, G.2    Paul, R.J.3
  • 2
    • 0013543367 scopus 로고
    • The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
    • Inoue A, Yanagisawa M, Kimura S, et al.: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 1989, 86:2863-2867.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2863-2867
    • Inoue, A.1    Yanagisawa, M.2    Kimura, S.3
  • 3
    • 0027164625 scopus 로고
    • Endothelins as regulators of growth and function in endocrine tissues
    • Kennedy RL, Haynes WG, Webb DJ: Endothelins as regulators of growth and function in endocrine tissues. Clin Endocrinol (Oxf) 1993, 39:259-265.
    • (1993) Clin Endocrinol (Oxf) , vol.39 , pp. 259-265
    • Kennedy, R.L.1    Haynes, W.G.2    Webb, D.J.3
  • 4
    • 0031829004 scopus 로고    scopus 로고
    • Endothelin as a regulator of cardiovascular function in health and disease
    • Haynes WG, Webb DJ: Endothelin as a regulator of cardiovascular function in health and disease. J Hypertens 1998, 16:1081-1098.
    • (1998) J Hypertens , vol.16 , pp. 1081-1098
    • Haynes, W.G.1    Webb, D.J.2
  • 5
    • 0026654495 scopus 로고
    • Role of neutral endopeptidase in the metabolism of endothelin
    • Abassi ZA, Tate JE, Golomb E, et al.: Role of neutral endopeptidase in the metabolism of endothelin. Hypertension 1992, 20:89-95.
    • (1992) Hypertension , vol.20 , pp. 89-95
    • Abassi, Z.A.1    Tate, J.E.2    Golomb, E.3
  • 6
    • 0036884694 scopus 로고    scopus 로고
    • New therapeutics that antagonize endothelin: Promises and frustrations
    • Remuzzi G, Perico N, Benigni A: New therapeutics that antagonize endothelin: promises and frustrations. Nat Rev Drug Discov 2002, 1:986-1001.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 986-1001
    • Remuzzi, G.1    Perico, N.2    Benigni, A.3
  • 7
    • 0029886596 scopus 로고    scopus 로고
    • Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans
    • Haynes WG, Ferro CJ, O'Kane KP, et al.: Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans. Circulation 1996, 93:1860-1870.
    • (1996) Circulation , vol.93 , pp. 1860-1870
    • Haynes, W.G.1    Ferro, C.J.2    O'Kane, K.P.3
  • 8
    • 0027757096 scopus 로고
    • Chronic pathophysiological circulating endothelin levels produce hypertension in conscious dogs
    • Wilkins FC, Alberola A, Mizelle HL, et al.: Chronic pathophysiological circulating endothelin levels produce hypertension in conscious dogs. J Cardiovasc Pharmacol 1993, 22:S325-S327.
    • (1993) J Cardiovasc Pharmacol , vol.22
    • Wilkins, F.C.1    Alberola, A.2    Mizelle, H.L.3
  • 9
    • 0027989765 scopus 로고
    • Effects of endothelin-1 on renal function in humans: Implications for physiology and pathophysiology
    • Rabelink TJ, Kaasjager KA, Boer P, et al.: Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology. Kidney Int 1994, 46:376-381.
    • (1994) Kidney Int , vol.46 , pp. 376-381
    • Rabelink, T.J.1    Kaasjager, K.A.2    Boer, P.3
  • 10
    • 0027959070 scopus 로고
    • Effect of a non-selective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats: Evidence for a role of endothelin in vascular hypertrophy
    • Li JS, Lariviere R, Schiffrin EL, et al.: Effect of a non-selective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats: evidence for a role of endothelin in vascular hypertrophy. Hypertension 1994, 24:183-188.
    • (1994) Hypertension , vol.24 , pp. 183-188
    • Li, J.S.1    Lariviere, R.2    Schiffrin, E.L.3
  • 11
    • 0029914353 scopus 로고    scopus 로고
    • Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats
    • Karam H, Heudes D, Hess P, et al.: Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats. Cardiovasc Res 1996, 31:287-295.
    • (1996) Cardiovasc Res , vol.31 , pp. 287-295
    • Karam, H.1    Heudes, D.2    Hess, P.3
  • 12
    • 0033042155 scopus 로고    scopus 로고
    • Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats
    • Matsumura Y, Hashimoto N, Taira S, et al.: Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats. Hypertension 1999, 33:759-765.
    • (1999) Hypertension , vol.33 , pp. 759-765
    • Matsumura, Y.1    Hashimoto, N.2    Taira, S.3
  • 13
    • 0034442454 scopus 로고    scopus 로고
    • Combined effects of AT(1) and ET(A) receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats
    • Pollock DM, Derebail VK, Yamamoto T, et al.: Combined effects of AT(1) and ET(A) receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats. Gen Pharmacol 2000, 34:337-342.
    • (2000) Gen Pharmacol , vol.34 , pp. 337-342
    • Pollock, D.M.1    Derebail, V.K.2    Yamamoto, T.3
  • 14
    • 0035569561 scopus 로고    scopus 로고
    • ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats
    • Park JB, Schiffrin EL: ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001, 37:1444-1449.
    • (2001) Hypertension , vol.37 , pp. 1444-1449
    • Park, J.B.1    Schiffrin, E.L.2
  • 15
    • 0031613530 scopus 로고    scopus 로고
    • ETA-receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
    • Barton M, d'Uscio LV, Shaw S, et al.: ETA-receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension. Hypertension 1998, 31:499-504.
    • (1998) Hypertension , vol.31 , pp. 499-504
    • Barton, M.1    d'Uscio, L.V.2    Shaw, S.3
  • 16
    • 0030767296 scopus 로고    scopus 로고
    • Structure and function of small arteries in salt-induced hypertension: Effects of chronic ETA-receptor blockade
    • d'Uscio L, Barton M, Shaw S, et al.: Structure and function of small arteries in salt-induced hypertension: effects of chronic ETA-receptor blockade. Hypertension 1997, 30:905-911.
    • (1997) Hypertension , vol.30 , pp. 905-911
    • d'Uscio, L.1    Barton, M.2    Shaw, S.3
  • 17
    • 0031606120 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats
    • Kassab S, Miller MT, Novak J, et al.: Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats. Hypertension 1998, 31:397-402.
    • (1998) Hypertension , vol.31 , pp. 397-402
    • Kassab, S.1    Miller, M.T.2    Novak, J.3
  • 18
    • 0032948745 scopus 로고    scopus 로고
    • Early, but not late-onset, endothelin-A receptor blockade can modulate hypertension, cerebral edema and proteinuria in stroke-prone hypertensive rats
    • Blezer ELA, Nicolay K, Goldschmeding R, et al.: Early, but not late-onset, endothelin-A receptor blockade can modulate hypertension, cerebral edema and proteinuria in stroke-prone hypertensive rats. Hypertension 1999, 33:137-144.
    • (1999) Hypertension , vol.33 , pp. 137-144
    • Blezer, E.L.A.1    Nicolay, K.2    Goldschmeding, R.3
  • 19
    • 0029966735 scopus 로고    scopus 로고
    • Effects of endothelin receptor inhibition on cerebral arterioles in hypertensive rats
    • Chillon J-M, Heistad DD, Baumbach GL: Effects of endothelin receptor inhibition on cerebral arterioles in hypertensive rats. Hypertension 1996, 27:794-798.
    • (1996) Hypertension , vol.27 , pp. 794-798
    • Chillon, J.-M.1    Heistad, D.D.2    Baumbach, G.L.3
  • 20
    • 0033752086 scopus 로고    scopus 로고
    • Endothelin-A receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats
    • Touyz RM, Turgeon A, Schiffrin EL: Endothelin-A receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 2000, 36:S300-S304.
    • (2000) J Cardiovasc Pharmacol , vol.36
    • Touyz, R.M.1    Turgeon, A.2    Schiffrin, E.L.3
  • 21
    • 0031941152 scopus 로고    scopus 로고
    • Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade
    • Herizi A, Jover B, Bouriquet N, et al.: Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade. Hypertension 1998, 31:10-14.
    • (1998) Hypertension , vol.31 , pp. 10-14
    • Herizi, A.1    Jover, B.2    Bouriquet, N.3
  • 22
    • 0028944170 scopus 로고
    • Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist
    • Li J-S, Schiffrin EL: Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension 1995, 25:495-500.
    • (1995) Hypertension , vol.25 , pp. 495-500
    • Li, J.-S.1    Schiffrin, E.L.2
  • 23
    • 0029823910 scopus 로고    scopus 로고
    • Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism
    • Karam H, Heudes D, Bruvenal P, et al.: Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension 1996, 28:379-385.
    • (1996) Hypertension , vol.28 , pp. 379-385
    • Karam, H.1    Heudes, D.2    Bruvenal, P.3
  • 24
    • 0030925245 scopus 로고    scopus 로고
    • Effects of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats
    • Schiffrin EL, Turgeon A, Deng LY: Effects of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats. Br J Pharmacol 1997, 121:935-940.
    • (1997) Br J Pharmacol , vol.121 , pp. 935-940
    • Schiffrin, E.L.1    Turgeon, A.2    Deng, L.Y.3
  • 25
    • 0027984808 scopus 로고
    • Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology
    • Rubanyi GM, Polokoff MA: Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 1994, 46:325-415.
    • (1994) Pharmacol Rev , vol.46 , pp. 325-415
    • Rubanyi, G.M.1    Polokoff, M.A.2
  • 26
    • 0026546369 scopus 로고
    • Captopril prevents chronic hypertension produced by infusion of endothelin-1 in rats
    • Mortensen LH, Fink ED: Captopril prevents chronic hypertension produced by infusion of endothelin-1 in rats. Hypertension 1992, 19:676-680.
    • (1992) Hypertension , vol.19 , pp. 676-680
    • Mortensen, L.H.1    Fink, E.D.2
  • 27
    • 0028277661 scopus 로고
    • In vitro perfusion studies of human resistance artery function in essential hypertension
    • Falloon BJ, Heagerty AM: In vitro perfusion studies of human resistance artery function in essential hypertension. Hypertension 1994, 24:16-23.
    • (1994) Hypertension , vol.24 , pp. 16-23
    • Falloon, B.J.1    Heagerty, A.M.2
  • 28
    • 0034107116 scopus 로고    scopus 로고
    • Cellular hypertrophy in subcutaneous small arteries of patients with renovascular hypertension
    • Rizzoni D, Porteri E, Guefi D, et al.: Cellular hypertrophy in subcutaneous small arteries of patients with renovascular hypertension. Hypertension 2000, 35:931-935.
    • (2000) Hypertension , vol.35 , pp. 931-935
    • Rizzoni, D.1    Porteri, E.2    Guefi, D.3
  • 29
    • 0032722115 scopus 로고    scopus 로고
    • Endothelin receptor antagonists: Novel agents for the treatment of hypertension
    • Dao HH, Moreau P: Endothelin receptor antagonists: novel agents for the treatment of hypertension. Exp Opin Invest Drugs 1999, 8:1807-1821.
    • (1999) Exp Opin Invest Drugs , vol.8 , pp. 1807-1821
    • Dao, H.H.1    Moreau, P.2
  • 30
    • 0034993096 scopus 로고    scopus 로고
    • Role of endothelin-1 in hypertension and vascular disease
    • Schiffrin EL: Role of endothelin-1 in hypertension and vascular disease. Am J Hypertension 2001, 14:83S-89S.
    • (2001) Am J Hypertension , vol.14
    • Schiffrin, E.L.1
  • 31
    • 0034755768 scopus 로고    scopus 로고
    • Norepineprhine-induced aortic hyperplasia and extracellular matrix deposition is endothelin-dependent
    • Dao HH, Lemay J, de Champlain J, et al.: Norepineprhine-induced aortic hyperplasia and extracellular matrix deposition is endothelin-dependent. J Hypertension 2001, 19:1965-1973.
    • (2001) J Hypertension , vol.19 , pp. 1965-1973
    • Dao, H.H.1    Lemay, J.2    de Champlain, J.3
  • 32
    • 0029823910 scopus 로고    scopus 로고
    • Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism
    • Karam H, Heudes D, Bruvenal P, et al.: Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension 1996, 28:379-385.
    • (1996) Hypertension , vol.28 , pp. 379-385
    • Karam, H.1    Heudes, D.2    Bruvenal, P.3
  • 33
    • 0033042155 scopus 로고    scopus 로고
    • Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats
    • Matsumura Y, Hashimoto N, Taira S, et al.: Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats. Hypertension 1999, 33:759-765.
    • (1999) Hypertension , vol.33 , pp. 759-765
    • Matsumura, Y.1    Hashimoto, N.2    Taira, S.3
  • 34
    • 0035895333 scopus 로고    scopus 로고
    • Myocardial fibrosis in DOCA-salt hypertensive rats: Effect of endothelin ETA receptor antagonism
    • Ammarguellat F, Larouche II, Schiffrin EL: Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ETA receptor antagonism. Circulation 2001, 103:319-324.
    • (2001) Circulation , vol.103 , pp. 319-324
    • Ammarguellat, F.1    Larouche, I.I.2    Schiffrin, E.L.3
  • 35
    • 0035940394 scopus 로고    scopus 로고
    • Long-term effects of nonselective endothelin A and B receptor antagonism in postinfarction rat: Importance of timing
    • Nguyen QT, Cernacek P, Sirois MG, et al.: Long-term effects of nonselective endothelin A and B receptor antagonism in postinfarction rat: importance of timing. Circulation 2001, 104:2075-2081.
    • (2001) Circulation , vol.104 , pp. 2075-2081
    • Nguyen, Q.T.1    Cernacek, P.2    Sirois, M.G.3
  • 36
    • 0346492721 scopus 로고    scopus 로고
    • The endothelin system in pulmonary arterial hypertension
    • Galie N, Manes A, Branzi A: The endothelin system in pulmonary arterial hypertension. Cardiovasc Res 2004, 61:227-237.
    • (2004) Cardiovasc Res , vol.61 , pp. 227-237
    • Galie, N.1    Manes, A.2    Branzi, A.3
  • 37
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study
    • Channick RN, Simonneau G, Sitbon O, et al.: Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 2001, 358:1119-1123.
    • (2001) Lancet , vol.358 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3
  • 38
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • Rubin LJ, Badesch DB, Barst RJ, et al.: Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002, 346:896-903.
    • (2002) N Engl J Med , vol.346 , pp. 896-903
    • Rubin, L.J.1    Badesch, D.B.2    Barst, R.J.3
  • 39
    • 0344837813 scopus 로고    scopus 로고
    • Effects of the oral endothelin receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension
    • Galie N, Hinderliter AL, Torbicki A, et al.: Effects of the oral endothelin receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension. J Am Coll Cardiol 2003, 41:1380-1386.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1380-1386
    • Galie, N.1    Hinderliter, A.L.2    Torbicki, A.3
  • 40
    • 0036283401 scopus 로고    scopus 로고
    • Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist in patients with pulmonary arterial hypertension: Open-label pilot study
    • Barst RJ, Rich S, Widlizt A, et al.: Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist in patients with pulmonary arterial hypertension: open-label pilot study. Chest 2002, 121:1860-1868.
    • (2002) Chest , vol.121 , pp. 1860-1868
    • Barst, R.J.1    Rich, S.2    Widlizt, A.3
  • 41
    • 10744230817 scopus 로고    scopus 로고
    • Sitaxsentan therapy for pulmonary arterial hypertension
    • Barst RJ, Langleben D, Frost A, et al.: Sitaxsentan therapy for pulmonary arterial hypertension. Am J Respir Crit Care Med 2004, 169:441-447.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 441-447
    • Barst, R.J.1    Langleben, D.2    Frost, A.3
  • 42
    • 33646024391 scopus 로고    scopus 로고
    • Preliminary results presented at the American Thoracic Society. San Diego, CA: American Thoracic Scoiety; May
    • Barst R: Preliminary results presented at the American Thoracic Society. San Diego, CA: American Thoracic Scoiety; May 2005.
    • (2005)
    • Barst, R.1
  • 43
    • 0035036050 scopus 로고    scopus 로고
    • The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
    • Fattinger K, Funk C, Pantze M, et al.: The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 2001, 69:223-231.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 223-231
    • Fattinger, K.1    Funk, C.2    Pantze, M.3
  • 44
    • 33646072540 scopus 로고    scopus 로고
    • Preliminary results presented by at the American Thoracic Society. Orlando, FL: American Thoracic Society; May
    • Rubin L: Preliminary results presented by at the American Thoracic Society. Orlando, FL: American Thoracic Society; May 2004.
    • (2004)
    • Rubin, L.1
  • 45
    • 33646059246 scopus 로고    scopus 로고
    • Ambrisentan in Patients with Moderate to Severe Pulmonary Arterial Hypertension (PAH)
    • ARIES: Accessed on 6/20/05
    • ARIES: Ambrisentan in Patients with Moderate to Severe Pulmonary Arterial Hypertension (PAH): http://www.clinicaltrials.gov/ct/show/NCT00091598. Accessed on 6/20/05.
  • 46
    • 0034993096 scopus 로고    scopus 로고
    • Role of endothelin-1 in hypertension and vascular disease
    • Schiffrin EL: Role of endothelin-1 in hypertension and vascular disease. Am J Hypertension 2001, 14:83S-89S.
    • (2001) Am J Hypertension , vol.14
    • Schiffrin, E.L.1
  • 47
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension
    • Bosentan Hypertension Investigators
    • Krum H, Viskoper RJ, Lacourciere Y, et al.: The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med 1998, 338:784-790.
    • (1998) N Engl J Med , vol.338 , pp. 784-790
    • Krum, H.1    Viskoper, R.J.2    Lacourciere, Y.3
  • 48
    • 0036634351 scopus 로고    scopus 로고
    • Darusentan: An effective endothelinA receptor antagonist for treatment of hypertension
    • For the HEAT Investigators
    • Nakov R, Pfarr E, Eberle S: Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension. For the HEAT Investigators. Am J Hypertens 2002, 15:583-589.
    • (2002) Am J Hypertens , vol.15 , pp. 583-589
    • Nakov, R.1    Pfarr, E.2    Eberle, S.3
  • 49
    • 0033066150 scopus 로고    scopus 로고
    • Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat
    • Spence S, Anderson C, Cukierski M, et al.: Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat. Reprod Toxicol 1999, 13:15-29.
    • (1999) Reprod Toxicol , vol.13 , pp. 15-29
    • Spence, S.1    Anderson, C.2    Cukierski, M.3
  • 50
    • 33646020774 scopus 로고    scopus 로고
    • Myogen Reports Positive Results for Darusentan Phase 2b Trial in Resistant Hypertension
    • Released on August 18th, Accessed at www.myogen.com
    • Myogen Reports Positive Results for Darusentan Phase 2b Trial in Resistant Hypertension. Released on August 18th, 2005. Accessed at www.myogen.com
    • (2005)
  • 51
    • 0038460302 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al.: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003, 289:2560-2572.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 52
    • 0027306052 scopus 로고
    • Urinary endothelin and sodium excretion in essential hypertension
    • Saito I, Mizuno K, Niimura S: Urinary endothelin and sodium excretion in essential hypertension. Nephron 1993, 65:152-153.
    • (1993) Nephron , vol.65 , pp. 152-153
    • Saito, I.1    Mizuno, K.2    Niimura, S.3
  • 53
    • 0033944995 scopus 로고    scopus 로고
    • Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension
    • Malatino LS, Bellanuova I, Cataliotti A, et al.: Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension. J Nephrol 2000, 13:178-184.
    • (2000) J Nephrol , vol.13 , pp. 178-184
    • Malatino, L.S.1    Bellanuova, I.2    Cataliotti, A.3
  • 54
    • 0029552380 scopus 로고
    • The atherogenic potential of endothelin
    • Hasdai D, Lerman A: The atherogenic potential of endothelin. Coron Artery Dis 1995, 6:901-904.
    • (1995) Coron Artery Dis , vol.6 , pp. 901-904
    • Hasdai, D.1    Lerman, A.2
  • 55
    • 0025940245 scopus 로고
    • Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis
    • Lerman A, Edwards BS, Hallet JW, et al.: Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 1991, 325:997-1001.
    • (1991) N Engl J Med , vol.325 , pp. 997-1001
    • Lerman, A.1    Edwards, B.S.2    Hallet, J.W.3
  • 56
    • 0033854558 scopus 로고    scopus 로고
    • Hypertension in black patients: An emerging role of the endohelin system in salt-sensitive hypertension
    • Ergul A: Hypertension in black patients: an emerging role of the endohelin system in salt-sensitive hypertension. Hypertension 2000, 36:62-67.
    • (2000) Hypertension , vol.36 , pp. 62-67
    • Ergul, A.1
  • 57
    • 0035895312 scopus 로고    scopus 로고
    • Regulation of plasma endothelin by salt in salt-sensitive hypertension
    • Elijovich F, Laffer CL, Amador B, et al.: Regulation of plasma endothelin by salt in salt-sensitive hypertension. Circulation 2001, 103:263-268.
    • (2001) Circulation , vol.103 , pp. 263-268
    • Elijovich, F.1    Laffer, C.L.2    Amador, B.3
  • 58
    • 1642282772 scopus 로고    scopus 로고
    • Endothelin-aldosterone interaction and proteinuria in low-renin hypertension
    • Elijovich F, Laffer CL, Schiffrin EL, et al.: Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. J Hypertens 2004, 22:573-582.
    • (2004) J Hypertens , vol.22 , pp. 573-582
    • Elijovich, F.1    Laffer, C.L.2    Schiffrin, E.L.3
  • 59
    • 16544375400 scopus 로고    scopus 로고
    • Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients
    • Campia U, Cardillo C, Panza JA: Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients. Circulation 2004, 109:3191-3195.
    • (2004) Circulation , vol.109 , pp. 3191-3195
    • Campia, U.1    Cardillo, C.2    Panza, J.A.3
  • 60
    • 33646052064 scopus 로고    scopus 로고
    • FDA Approves BiDil Heart Failure Drug for Black Patients
    • Accessed on June 27
    • FDA Approves BiDil Heart Failure Drug for Black Patients. http://www.fda.gov/bbs/topics/NEWS/2005/NEW01190.html. Accessed on June 27, 2005.
    • (2005)
  • 61
    • 0027396077 scopus 로고
    • Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensives but not in spontaneously hypertensive rats
    • Lariviere R, Thibault G, Schiffrin EL: Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensives but not in spontaneously hypertensive rats. Hypertension 1993, 21:294-300.
    • (1993) Hypertension , vol.21 , pp. 294-300
    • Lariviere, R.1    Thibault, G.2    Schiffrin, E.L.3
  • 62
    • 0026654495 scopus 로고
    • Role of neutral endopeptidase in the metabolism of endothelin
    • Abassi ZA, Tate JE, Golomb E: Role of neutral endopeptidase in the metabolism of endothelin. Hypertension 1992, 20:89-95.
    • (1992) Hypertension , vol.20 , pp. 89-95
    • Abassi, Z.A.1    Tate, J.E.2    Golomb, E.3
  • 63
    • 0033944995 scopus 로고    scopus 로고
    • Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension
    • Salt Sensitivity Group of the Italian Society of Hypertension
    • Malatino LS, Bellanuova I, Cataliotti A, et al.: Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension. Salt Sensitivity Group of the Italian Society of Hypertension. J Nephrol 2000, 13:178-184.
    • (2000) J Nephrol , vol.13 , pp. 178-184
    • Malatino, L.S.1    Bellanuova, I.2    Cataliotti, A.3
  • 64
    • 0031791973 scopus 로고    scopus 로고
    • Circadian rhythm of urinary endothelin-1 excretion in mild hypertensive patients
    • Hwang YS, Hsieh TJ, Lee YJ, et al.: Circadian rhythm of urinary endothelin-1 excretion in mild hypertensive patients. Am J Hypertens 1998, 11:1344-1351.
    • (1998) Am J Hypertens , vol.11 , pp. 1344-1351
    • Hwang, Y.S.1    Hsieh, T.J.2    Lee, Y.J.3
  • 65
    • 0035984995 scopus 로고    scopus 로고
    • Participation of renal and circulating endothelin in salt-sensitive hypertension
    • Elijovich F, Laffer CL: Participation of renal and circulating endothelin in salt-sensitive hypertension. J Hum Hypertens 2002, 16:459-467.
    • (2002) J Hum Hypertens , vol.16 , pp. 459-467
    • Elijovich, F.1    Laffer, C.L.2
  • 66
    • 0037409319 scopus 로고    scopus 로고
    • Obesity-associated activation of angiotensin and endothelin in the cardiovascular system
    • Barton M, Carmona R, Ortmann, et al.: Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol 2003, 35:826-837.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 826-837
    • Barton, M.1    Carmona, R.2    Ortmann3
  • 67
    • 8444238229 scopus 로고    scopus 로고
    • Endothelin-1 plasma concentration in children and adolescents with atherogenic risk factors
    • Glowinska B, Urban M, Hryniewicz A: Endothelin-1 plasma concentration in children and adolescents with atherogenic risk factors. Kardiol Pal 2004, 61:329-338.
    • (2004) Kardiol Pal , vol.61 , pp. 329-338
    • Glowinska, B.1    Urban, M.2    Hryniewicz, A.3
  • 68
    • 1542270314 scopus 로고    scopus 로고
    • Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans
    • Pontiroli AE, Pizzocri P, Koprivec D, et al.: Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans. Eur J Endocrinol 2004, 150:195-200.
    • (2004) Eur J Endocrinol , vol.150 , pp. 195-200
    • Pontiroli, A.E.1    Pizzocri, P.2    Koprivec, D.3
  • 69
    • 3242787236 scopus 로고    scopus 로고
    • Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes
    • Mather KJ, Lteif A, Steinberg HO, et al.: Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes 2004, 53:2060-2066.
    • (2004) Diabetes , vol.53 , pp. 2060-2066
    • Mather, K.J.1    Lteif, A.2    Steinberg, H.O.3
  • 70
    • 0037900056 scopus 로고    scopus 로고
    • Pathophysiological implications of insulin resistance on vascular endothelial function
    • Wheatcroft SB, Williams IL, Shah AM: Pathophysiological implications of insulin resistance on vascular endothelial function. Diabet Med 2003, 20:255-268.
    • (2003) Diabet Med , vol.20 , pp. 255-268
    • Wheatcroft, S.B.1    Williams, I.L.2    Shah, A.M.3
  • 72
    • 12144282024 scopus 로고    scopus 로고
    • Effects of magnesium sulfate on lipid peroxidation and blood pressure regulators in preeclampsia
    • Ariza AC, Bobadilla N, Fernandez C, et al.: Effects of magnesium sulfate on lipid peroxidation and blood pressure regulators in preeclampsia. Clin Biochem 2005, 38:128-133.
    • (2005) Clin Biochem , vol.38 , pp. 128-133
    • Ariza, A.C.1    Bobadilla, N.2    Fernandez, C.3
  • 73
    • 0035090181 scopus 로고    scopus 로고
    • Endothelin type A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure
    • Alexander BT, Rinewalt AT, Cockrell KL, et al.: Endothelin type A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure. Hypertension 2001, 37:485-9.
    • (2001) Hypertension , vol.37 , pp. 485-489
    • Alexander, B.T.1    Rinewalt, A.T.2    Cockrell, K.L.3
  • 74
    • 0029906456 scopus 로고    scopus 로고
    • Effects of endothelin-1 and the ETA receptor antagonist BQ-123 on resistance arteries from normal pregnant and preeclamptic women
    • Wolff K, Kublickiene KR, Kublickas M, et al.: Effects of endothelin-1 and the ETA receptor antagonist BQ-123 on resistance arteries from normal pregnant and preeclamptic women. Acta Obstet Gynecol Scand 1996, 75:432-438.
    • (1996) Acta Obstet Gynecol Scand , vol.75 , pp. 432-438
    • Wolff, K.1    Kublickiene, K.R.2    Kublickas, M.3
  • 75
    • 0033849149 scopus 로고    scopus 로고
    • Nitric oxide dysfunction in the pathophysiology of preeclampsia
    • Lowe DT: Nitric oxide dysfunction in the pathophysiology of preeclampsia. Nitric Oxide 2000, 4:441-458.
    • (2000) Nitric Oxide , vol.4 , pp. 441-458
    • Lowe, D.T.1
  • 76
    • 18244427462 scopus 로고    scopus 로고
    • The effect of treatment on endothelin-1 concentration and mean arterial pressure in preeclampsia and eclampsia
    • Sagsoz N, Kucukozkan T: The effect of treatment on endothelin-1 concentration and mean arterial pressure in preeclampsia and eclampsia. Hypertens Pregnancy 2003, 22:185-191.
    • (2003) Hypertens Pregnancy , vol.22 , pp. 185-191
    • Sagsoz, N.1    Kucukozkan, T.2
  • 77
    • 0028367599 scopus 로고
    • Physiologic and pathophysiologic roles of endothelin in the kidney
    • Clavell AL, Burnett JC: Physiologic and pathophysiologic roles of endothelin in the kidney. Curr Opin Nephrol Hypertens 1994, 3:66-72.
    • (1994) Curr Opin Nephrol Hypertens , vol.3 , pp. 66-72
    • Clavell, A.L.1    Burnett, J.C.2
  • 78
    • 0037625278 scopus 로고    scopus 로고
    • Endothelin-1 in chronic renal failure and hypertension
    • Lariviere R, Lebel M: Endothelin-1 in chronic renal failure and hypertension. Can J Physiol Pharmacol 2003, 81:607-621.
    • (2003) Can J Physiol Pharmacol , vol.81 , pp. 607-621
    • Lariviere, R.1    Lebel, M.2
  • 79
    • 0032699644 scopus 로고    scopus 로고
    • Physiology and pathophysiology of nitric oxide in chronic renal disease
    • Noris M, Remuzzi G: Physiology and pathophysiology of nitric oxide in chronic renal disease. Proc Assoc Am Physicians 1999, 111:602-610.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 602-610
    • Noris, M.1    Remuzzi, G.2
  • 80
    • 0032934833 scopus 로고    scopus 로고
    • Endothelin receptor antagonists influence cardiovascular morphology in uremic rats
    • Nabokov AV, Amann K, Wessels S, et al.: Endothelin receptor antagonists influence cardiovascular morphology in uremic rats. Kidney Int 1999, 55:512-519.
    • (1999) Kidney Int , vol.55 , pp. 512-519
    • Nabokov, A.V.1    Amann, K.2    Wessels, S.3
  • 81
    • 0032796241 scopus 로고    scopus 로고
    • Endothelin ET(A) receptor blockade prevents the progression of renal failure and hypertension in uraemic rats
    • Brochu E, Lacasse S, Moreau C, et al.: Endothelin ET(A) receptor blockade prevents the progression of renal failure and hypertension in uraemic rats. Nephrol Dial Transplant 1999, 14:1881-1888.
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 1881-1888
    • Brochu, E.1    Lacasse, S.2    Moreau, C.3
  • 82
    • 0032857428 scopus 로고    scopus 로고
    • Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats
    • Shimizu T, Hata S, Kuroda T, et al.: Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats. Eur J Pharmacol 1999, 381:39-49.
    • (1999) Eur J Pharmacol , vol.381 , pp. 39-49
    • Shimizu, T.1    Hata, S.2    Kuroda, T.3
  • 83
    • 0034115616 scopus 로고    scopus 로고
    • Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism
    • Wang A, Holcslaw T, Bashore TM, et al.: Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism. Kidney Int 2000, 57:1675-1680.
    • (2000) Kidney Int , vol.57 , pp. 1675-1680
    • Wang, A.1    Holcslaw, T.2    Bashore, T.M.3
  • 84
    • 0029847636 scopus 로고    scopus 로고
    • Pulmonary clearance of circulating endothelin-1 in dogs in vivo: Exclusive role of ETB receptors
    • Dupuis J, Goresky CA, Fournier A: Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors. J Appl Physiol 1996, 81:1510-1515.
    • (1996) J Appl Physiol , vol.81 , pp. 1510-1515
    • Dupuis, J.1    Goresky, C.A.2    Fournier, A.3
  • 85
    • 0036670234 scopus 로고    scopus 로고
    • Endothelin receptor A blockade reduces proteinuria and vascular hypertrophy in spontaneously hypertensive rats on high-salt diet in a blood-pressure-independent manner
    • Trenkner J, Priem F, Bauer C, et al.: Endothelin receptor A blockade reduces proteinuria and vascular hypertrophy in spontaneously hypertensive rats on high-salt diet in a blood-pressure-independent manner. Clin Sci (Lond) 2002, 103(Suppl 48):385S-388S.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Trenkner, J.1    Priem, F.2    Bauer, C.3
  • 86
    • 1542514709 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: A comparison of selective and combined endothelin receptor blockade
    • Goddard J, Johnston NR, Hand MF, et al.: Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation 2004, 109:1186-1193.
    • (2004) Circulation , vol.109 , pp. 1186-1193
    • Goddard, J.1    Johnston, N.R.2    Hand, M.F.3
  • 87
    • 0031738068 scopus 로고    scopus 로고
    • Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here?
    • National Kidney Foundation Task Force on Cardiovascular Disease
    • Levey AS, Beto JA, Coronado BE, et al.: Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here? National Kidney Foundation Task Force on Cardiovascular Disease. Am J Kidney Dis 1998, 32:853-906.
    • (1998) Am J Kidney Dis , vol.32 , pp. 853-906
    • Levey, A.S.1    Beto, J.A.2    Coronado, B.E.3
  • 88
    • 0027487008 scopus 로고
    • Cyclosporine-induced elevation in circulating endothelin-1 in patients with solid-organ transplants
    • Grieff M, Loertscher R, Shohaib SA, et al.: Cyclosporine-induced elevation in circulating endothelin-1 in patients with solid-organ transplants. Transplantation 1993, 56:880-884.
    • (1993) Transplantation , vol.56 , pp. 880-884
    • Grieff, M.1    Loertscher, R.2    Shohaib, S.A.3
  • 89
    • 0028789944 scopus 로고
    • Cyclosporine A stimulates endothelin release
    • Haug C, Duell T, Voisard R, et al.: Cyclosporine A stimulates endothelin release. J Cardiovasc Pharmacol 1995, 26(Suppl3):S239-S241.
    • (1995) J Cardiovasc Pharmacol , vol.26 , Issue.SUPPL. 3
    • Haug, C.1    Duell, T.2    Voisard, R.3
  • 90
    • 0030010924 scopus 로고    scopus 로고
    • Bosentan ameliorates cyclosporin A-induced hypertension in rats and primates
    • Bartholomeusz B, Hardy KJ, Nelson AS, et al.: Bosentan ameliorates cyclosporin A-induced hypertension in rats and primates. Hypertension 1996, 27:1341-1345.
    • (1996) Hypertension , vol.27 , pp. 1341-1345
    • Bartholomeusz, B.1    Hardy, K.J.2    Nelson, A.S.3
  • 91
    • 0036670293 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endotbelin-1 secretion in cultured endothelial cells
    • Kandoussi A, Martin F, Hazzan M, et al.: HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endotbelin-1 secretion in cultured endothelial cells. Clin Sci (Lond) 2002, 103 (Suppl48):81S-83S.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Kandoussi, A.1    Martin, F.2    Hazzan, M.3
  • 92
    • 15944366914 scopus 로고    scopus 로고
    • Effects of statins on vascular function of endothelin-1
    • Mraiche F, Cena J, Das D, et al.: Effects of statins on vascular function of endothelin-1. Br J Pharmacol 2005, 144:715-726.
    • (2005) Br J Pharmacol , vol.144 , pp. 715-726
    • Mraiche, F.1    Cena, J.2    Das, D.3
  • 93
    • 0028791597 scopus 로고
    • Treatment of renal anemia by erythropoietin substitution: The effects on the cardiovascular system
    • Radermacher J, Koch KM: Treatment of renal anemia by erythropoietin substitution: the effects on the cardiovascular system. Clin Nephrol 1995, 44(Suppl1):S56-S60.
    • (1995) Clin Nephrol , vol.44 , Issue.SUPPL. 1
    • Radermacher, J.1    Koch, K.M.2
  • 94
    • 0033032954 scopus 로고    scopus 로고
    • Differential effects of endothelin-1 antagonists on erythropoietin-induced hypertension in renal failure
    • Brochu E, Lacasse S, Lariviere R, et al.: Differential effects of endothelin-1 antagonists on erythropoietin-induced hypertension in renal failure. J Am Soc Nephrol 1999, 10:1440-1446.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1440-1446
    • Brochu, E.1    Lacasse, S.2    Lariviere, R.3
  • 95
    • 0030917561 scopus 로고    scopus 로고
    • Circulating endothelin-1 in obstructive sleep apnea
    • Saarelainen S, Seppala E, Laasonen KC, et al.: Circulating endothelin-1 in obstructive sleep apnea. Endothelium 1997, 5:115-118.
    • (1997) Endothelium , vol.5 , pp. 115-118
    • Saarelainen, S.1    Seppala, E.2    Laasonen, K.C.3
  • 96
    • 0033950071 scopus 로고    scopus 로고
    • Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnoea
    • Grimpen F, Kanne P, Schulz E, et al.: Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnoea. Eur Respir J 2000, 15:320-325.
    • (2000) Eur Respir J , vol.15 , pp. 320-325
    • Grimpen, F.1    Kanne, P.2    Schulz, E.3
  • 97
    • 1442286779 scopus 로고    scopus 로고
    • Cardiovascular consequences of sleep-disordered breathing: Past, present and future: Report of a workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute
    • Quan SF, Gersh BJ: Cardiovascular consequences of sleep-disordered breathing: past, present and future: report of a workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute. Circulation 2004, 109:951-957.
    • (2004) Circulation , vol.109 , pp. 951-957
    • Quan, S.F.1    Gersh, B.J.2
  • 98
    • 0032976443 scopus 로고    scopus 로고
    • Effects of obstructive sleep apnea on endothelin-1 and blood pressure
    • Phillips BC, Narkiewicz K, Pesek CA, et al.: Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999, 17:61-66.
    • (1999) J Hypertens , vol.17 , pp. 61-66
    • Phillips, B.C.1    Narkiewicz, K.2    Pesek, C.A.3
  • 99
    • 21244454076 scopus 로고    scopus 로고
    • Prolonged activation of the baroreflex: A viable approach for the treatment of hypertension
    • Lohmeier T, Barrett A, Irwin E: Prolonged activation of the baroreflex: a viable approach for the treatment of hypertension. Curr Hypertens Rep 2005, 7:193-198.
    • (2005) Curr Hypertens Rep , vol.7 , pp. 193-198
    • Lohmeier, T.1    Barrett, A.2    Irwin, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.